The increasing global population, rapid urbanization, and climate change are putting unprecedented pressure on limited water and energy resources for food production. It requires integrated management of the key resources to achieve economic and environmental sustainability. The water-energy-food (WEF) nexus, in conjunction with circular bioeconomy (CBE) principles, offer a promising approach to achieve sustainable agriculture. It provides the integration between interconnectedness and interdependencies of the resources through closing bio-resource loops. Using bio-based materials, renewable energy resources, and implementing energy-efficient practices and technologies can maximize synergistic among the resources and promote sustainable agriculture while minimizing negative environmental impacts. However, there are challenges and limitations, such as economic conditions, proper infrastructure and technology, policy and governance support, public awareness, and potential trade-offs and conflicts. Moreover, it also faces various social and cultural challenges in implementing this approach. Therefore, to overcome these challenges and limitations, the need for innovative and sustainable technologies, significant investments in research and development, infrastructure and training, environmental campaign, innovative financing mechanisms and policies that incentivize sustainable practices, and support from stakeholders and the public are essential.