The recently discovered Dongbulage Mo-polymetallic deposit is located in the southern part of the Great Xing'an Range, northeast China. Mineralization is closely related to the emplacement of Middle-Late Jurassic granitoids. In order to understand the petrogenetic link between mineralization and host granitoids, this study presents new zircon U-Pb ages, bulk-rock geochemistry, and molybdenite Re-Os ages for the Dongbulage deposits. LA-ICP-MS zircon U-Pb dating of the monzogranite and syenogranite intrusions yielded two weighted mean 206 Pb/ 238 U ages: of 164 ± 2 Ma and 165 ± 3 Ma, respectively. The subvolcanic rocks (red porphyritic granite and rhyolite) yielded a time interval between 161 ± 2 and 162 ± 3 Ma. In addition, molybdenite from the Dongbulage deposit gave a Re-Os isochron age of 162.6 ± 1.5 Ma, which was interpreted as the age of the mineralization. The new geochronology has established the close temporal and genetic relationships between the mineralization event and the emplacement of the Middle-Late Jurassic granitoids. Bulk-rock geochemistry shows that the Dongbulage granitoids are characterized by high SiO 2 , K 2 O, and A/CNK [Al 2 O 3 /(CaO + Na 2 O + K 2 O)(molar ratio)] values, and low TiO 2 , CaO, and MgO values, indicating a metaluminous to peraluminous, high-K calc-alkaline affinity. The granitoids also featured enrichments of large ion lithophile elements and light rare earth elements (LREE), and a relative depletion of high field strength elements (HFSE), along with an increasing negative δEu anomaly. The high differentiation index (DI), ranging from 81.75 to 94.76, and obvious fractionation between LREE and HREE, indicate that the Dongbulage granitoids are highly fractionated, metaluminous-peraluminous, and high-K calc-alkaline I-type granites. Combined with the regional geology, the Dongbulage granitoids may have formed during post-orogenic extension that followed the Mongol-Okhotsk Ocean closure coeval with subduction of the paleo-Pacific plate.Minerals 2019, 9, 255 2 of 34 source in China. This region is characterized by abundant highly evolved Mesozoic igneous rocks [2], and contains large-scale Ag-, Sn-, Mo-, and Cu-polymetallic vein deposits (Figure 1a) [3,4]. In this region, seven large base metal (≥0.5 Mt) and rare metal (≥0.2 Mt) deposits, and 25 smaller (0.1-0.5 Mt) base metal deposits have been discovered [5]. Three newly recognized metallogenic belts are located within the Great Xing'an Range and its adjacent areas. These are: the northern Mo ± Cu ore-forming belt; the middle Sn ± W ± Ag metallogenic belt; and the southern Mo ore-forming belt (Figure 1b) [6]. The recently discovered Dongbulage deposit is located where the northern Mo ± Cu and middle Sn ± W ± Ag mineralization belts come together (Figure 1b). The deposit represents an unusual example of Mo-polymetallic mineralization dominated by abundant Mo-Pb-Zn with minor Ag-Cu mineralization. The polymetallic features of the Dongbulage deposit represent a change in the style of mineralization characteristics between the Sn...