Hydrothermal synthesis of highly luminescent blue-emitting ZnSe(S) quantum dots exhibiting low toxicity

Mirnajafizadeh, Fatemeh; Ramsey, Deborah M.; McAlpine, Shelli R.; Wang, Fan; Reece, Peter J.; Stride, John A.

doi:10.1016/j.msec.2016.03.061

Cited by 35 publications

(11 citation statements)

References 40 publications

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“…3.1 Synthesis of QDs: the method of synthesising QDs can play an important role in the overall toxicity, with literature reports indicating that QDs synthesized in organic solvents tend to be more toxic than those synthesized by aqueous pathways [46][47][48]. However, the toxicity of Cd-based QDs has largely been attributed to the free Cd ions existing in equilibrium with the QDs in solution [11,30,49].…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible Quantum Dots

Mirnajafizadeh¹,

Ramsey²,

McAlpine³

et al. 2018

Preprint

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Abstract:Semiconductor nanocrystals or quantum dots (QDs), have unique optical and physical properties that make them potential imaging tools in biological and medical applications. However, concerns such as the aqueous dispersivity, toxicity to cells and stability in biological environments may limit the use of QDs in bioapplications. Here, we report an investigation into the cytotoxicity of aqueously dispersed CdSe(S) and CdSe(S)/ZnO core/shell QDs in the presence of human colorectal carcinoma cells and a human skin fibroblast cell line (WS-1). The cytotoxicity of the precursor solutions used in the synthesis of the CdSe(S) QDs was also determined in the presence of HCT-116 cells and compared to that of the heat-shock protein (Hsp90) inhibitor, 17-AAG. CdSe(S) QDs were found to have a low toxicity at concentrations up to 100 µg/ml, with a decreased cell viability at higher concentrations, indicating a highly dose-dependent response. Meanwhile, CdSe(S)/ZnO core/shell QDs exhibited lower toxicity than uncoated QDs at higher concentrations. Confocal microscopy images of HCT-116 cells after incubation with CdSe(S) and CdSe(S)/ZnO QDs showed that the cells were stable in aqueous concentrations of 100 µg of QDs per ml, with no sign of cell necrosis, confirming the cytotoxicity data.

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Section: Resultsmentioning

confidence: 99%

Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible Quantum Dots

Mirnajafizadeh¹,

Ramsey²,

McAlpine³

et al. 2018

Preprint

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“…First of all, compared to CdS and CdSe, ZnSe has significant advantages in the UV-blue region due to the larger band gap of 2.7 eV 17 and less toxicity. 18 It is resulted that ZnSe has been used in many photoelectric fields, including lasers, 19 thin-film transistors, 20 cell imaging, 21 blue light-emitting devices, 22 solar cells, 23 etc. Second, nanostructured films and quantum dots have similar properties, such as high luminous efficiency, good stability, and adjustable emission spectra.…”

Section: Introductionmentioning

confidence: 99%

Effect of Preparation Parameters on Deep-Blue Light-Emitting Diodes Based on Nanostructured ZnSe/ZnS Multilayer Films

Bai

Huang

et al. 2020

ACS Omega

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Compared to colloidal quantum dots, nanostructured multilayer films may also be a promising emission layer in future light-emitting diodes, due to their excellent photoluminescence (PL), narrow full width at half-maximum (FWHM), and wide color gamut. In this paper, multilayer-structured deep-blue light-emitting diodes (LEDs) were prepared, where nanostructured ZnSe/ZnS multilayer films act as the light-emitting layer. The device showed good blue electroluminescence (EL) spectrum locating at 448 nm with an FWHM of 31 nm. To improve the performance of the device, the effect of preparation parameters of different layers was investigated in detail. The results demonstrated that the preparation parameters of each layer affected the performance in different ways, and choosing the most suitable preparation parameters can achieve optimal performance. Furthermore, this multilayer-structured device based on nanostructured films as emission layer can also be applied in green and red LEDs or all-inorganic QLEDs.

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“…This has led to them being classified as a powerful new class of bio-imaging tools [1,2,3,4,5,6,7,8,9,10]. Despite the desirability of using QDs as intense fluorescent nanoscale markers in biological applications, cytotoxicity is a serious constraint that limits potential uses [11,12,13]. QDs can be considered as being potentially toxic due to both their nanoscale size and the presence of heavy metals [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the desirability of using QDs as intense fluorescent nanoscale markers in biological applications, cytotoxicity is a serious constraint that limits potential uses [11,12,13]. QDs can be considered as being potentially toxic due to both their nanoscale size and the presence of heavy metals [12,13]. Nanoscale particles can have a greater toxicity than bulk counterparts, with the small size enabling greater penetration into cells than corresponding bulk chemical materials [14].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible CdSe(S) and CdSe(S)/ZnO Quantum Dots

et al. 2019

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Semiconductor nanocrystals or quantum dots (QDs) have unique optical and physical properties that make them potential imaging tools in biological and medical applications. However, concerns over the aqueous dispersivity, toxicity to cells, and stability in biological environments may limit the use of QDs in such applications. Here, we report an investigation into the cytotoxicity of aqueously dispersed CdSe(S) and CdSe(S)/ZnO core/shell QDs in the presence of human colorectal carcinoma cells (HCT-116) and a human skin fibroblast cell line (WS1). The cytotoxicity of the precursor solutions used in the synthesis of the CdSe(S) QDs was also determined in the presence of HCT-116 cells. CdSe(S) QDs were found to have a low toxicity at concentrations up to 100 µg/mL, with a decreased cell viability at higher concentrations, indicating a highly dose-dependent response. Meanwhile, CdSe(S)/ZnO core/shell QDs exhibited lower toxicity than uncoated QDs at higher concentrations. Confocal microscopy images of HCT-116 cells after incubation with CdSe(S) and CdSe(S)/ZnO QDs showed that the cells were stable in aqueous concentrations of 100 µg of QDs per mL, with no sign of cell necrosis, confirming the cytotoxicity data.

show abstract

Hydrothermal synthesis of highly luminescent blue-emitting ZnSe(S) quantum dots exhibiting low toxicity

Cited by 35 publications

References 40 publications

Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible Quantum Dots

Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible Quantum Dots

Effect of Preparation Parameters on Deep-Blue Light-Emitting Diodes Based on Nanostructured ZnSe/ZnS Multilayer Films

Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible CdSe(S) and CdSe(S)/ZnO Quantum Dots

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