Hydrotropic Solubilization of Poorly Water-Soluble Drugs

Kim, Ji Young; Kim, Sung-Won; Papp, M.; Park, Kinam; Pinal, Rodolfo

doi:10.1002/jps.22241

Cited by 130 publications

(111 citation statements)

References 59 publications

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“…Hydrotropic solubilization of CoQ10 was attempted using N,N-diethylnicotinamide and N,N-diethylbenzamide hydrotropes. The later hydrotrope resulted in a 1000-fold increase in the aqueous solubility due to a more hydrophobic nature and hence more solubilizing power (Kim et al, 2010). Ullmann et al (2005) reported All-Q Õ , a starch-based tablet formulation of CoQ10, and compared its bioavailability to two other CoQ10 formulations namely: Q-Gel softsules and Q-SorB in 12 human volunteers.…”

Section: Complexesmentioning

confidence: 99%

Strategies for oral delivery and mitochondrial targeting of CoQ10

Zaki

2014

Drug Delivery

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Coenzyme Q10 (CoQ10), also known as ubiquinone or ubidecarenone, is a powerful, endogenously produced, intracellularly existing lipophilic antioxidant. It combats reactive oxygen species (ROS) known to be responsible for a variety of human pathological conditions. Its target site is the inner mitochondrial membrane (IMM) of each cell. In case of deficiency and/or aging, CoQ10 oral supplementation is warranted. However, CoQ10 has low oral bioavailability due to its lipophilic nature, large molecular weight, regional differences in its gastrointestinal permeability and involvement of multitransporters. Intracellular delivery and mitochondrial target ability issues pose additional hurdles. To maximize CoQ10 delivery to its biopharmaceutical target, numerous approaches have been undertaken. The review summaries the current research on CoQ10 bioavailability and highlights the headways to obtain a satisfactory intracellular and targeted mitochondrial delivery. Unresolved questions and research gaps were identified to bring this promising natural product to the forefront of therapeutic agents for treatment of different pathologies.

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Section: Complexesmentioning

confidence: 99%

Strategies for oral delivery and mitochondrial targeting of CoQ10

Zaki

2014

Drug Delivery

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“…In particular, analysis of quantitative thermodynamic information on hetero-association has established a correlation between K h (or other binding parameters) and changes in the in vitro biological effect for various aromatic mutagens and antibiotics [44,132], and with solubility enhancement for various aromatic hydrotropes [50,51].…”

Section: Hetero-association Of Aromatic Drugs With Aromatic Interceptmentioning

confidence: 99%

Hetero-association of aromatic molecules in aqueous solution

Evstigneev

2014

International Reviews in Physical Chemistry

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Knowledge of the physical chemistry of small molecules complexation (the hetero-association) in aqueous solution is increasingly important in view of the rapidly emerging branch of supramolecular chemistry dealing with the formation of heterogeneous polymeric structures having specific functional roles. In this paper, the 50-year history of scientific studies of hetero-association of heterocyclic aromatic molecules in aqueous solution has been reviewed. Some important correlations of structural and thermodynamic parameters of complexation have been reported based on large data-set of hetero-association parameters accumulated to date. The fundamental problem of 'energetic composition' of π-stacking is extensively discussed. The review has shown that there are some gaps in our understanding of heteroassociation, which provides a challenge for further studies in this area.

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“…Hydrotropy, the process whereby the presence of a large quantity of one solute enhances the solubility of another solute, is an important technique to solubilize poorly water-soluble pharmaceutical compounds (Hodgdon and Kaler, 2007;Kim et al, 2010). It is also an important strategy being considered to prepare hydrophobic substances aqueous solution (Eastoe et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique

et al. 2015

European Journal of Pharmaceutical Sciences

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Hydrotropic Solubilization of Poorly Water-Soluble Drugs

Cited by 130 publications

References 59 publications

Strategies for oral delivery and mitochondrial targeting of CoQ10

Strategies for oral delivery and mitochondrial targeting of CoQ10

Hetero-association of aromatic molecules in aqueous solution

A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique

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