Hydroxamic Acids as Inhibitors of Urease in the Treatment of Helicobacter pylori Infections

Bismuth(iii) benzohydroxamates: powerful anti-bacterial activity against Helicobacter pylori and hydrolysis to a unique Bi34 oxido-cluster [Bi34O22(BHA)22(H-BHA)14(DMSO)6]

“…16 Hydroxamic acids, particularly acetohydroxamic acid, are also known as urease inhibitors and so have been proposed as drug candidates for the treatment of H. pylori, though no compounds are yet clinically available. 17 Taking this in conjunction with our knowledge of the close relationship of Bi 3+ and Fe 3+ in the lifecycle and killing of H. pylori, it is clear that bismuth(III) hydroxamates deserve closer examination as possible combination drugs for the treatment and eradication of H. pylori. In fact the role of hydroxamates as siderophores means they could have much broader application as novel anti-bacterial compounds.…”