Hydroxyapatite: a promising hemostatic component in orthopaedic applications

Hydroxyapatite, a naturally occurring form of calcium phosphate, is the main mineral component of bones and teeth. Natural hydroxyapatite and bone have similar physical and chemical characteristics make it biocompatible. Its porous structure resembles native bone. The biocompatibility, biodegradability and bioactivity make it extensively useful in interdisciplinary fields of sciences like chemistry, biology, and medicine. Calcium phosphate-based ceramics are of great interest as substitutes of synthetic bone graft due to their similarities in composition to bone mineral and bioactivity as well as osteoconductivity. This article gives an overview of hydroxyapatite from its preparation and properties to biomedical applications of its composites.

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“…[9]. Recently, hydroxyapatite has attracted interests because of its hemostatic properties, and bone healing function [10] [11] [12].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite: Preparation, Properties and Its Biomedical Applications

Pokhrel¹

2018

ACES

100

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“…The authors detected only minor (not exceeding a few seconds) differences in the parameters measured that depended on the amount of HAp in the specimen used. Yet another group of investigators [33] examined the impact of various materials, including HAp, on in vitro clotting processes in human blood. HAp was shown to be a recommended hemostatic agent for bone engineering.…”

Section: Discussionmentioning

confidence: 99%

Parameters of Hemostasis in Sheep Implanted with Composite Scaffold Settled by Stimulated Mesenchymal Stem Cells—Evaluation of the Animal Model

et al. 2021

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Implantation of composite scaffolds could be potentially associated with the risk of hemostatic disturbances in a recipient. However, there is a lack of information on possible alterations in clotting mechanisms resulting from such a procedure. The aim of the present work was to investigate changes in hemostatic parameters in sheep implanted with a scaffold composed of poly(ε-caprolactone) and hydroxyapatite and tricalcium phosphate (9:4.5:4.5), settled previously with mesenchymal stem cells stimulated by fibroblast growth factor-2 and bone morphogenetic protein-2. Nine Merino sheep were examined for 7 days, and measurements of clotting times (PT, aPTT), activities of antithrombin, protein C and clotting factors II-XII, and concentrations of fibrinogen and D-dimer were carried out before and 1 h, 24 h, 3 days and 7 days after scaffold implantation. The introduction of scaffold initially resulted in a slowdown of the clotting processes (most evident 24 h after surgery); PT and aPTT increased to 14.8 s and 33.9 s, respectively. From the third day onwards, most of these alterations began to return to normal values. The concentration of fibrinogen rose throughout the observation period (up to 8.4 g/L), mirroring the ongoing inflammatory reaction. However, no signals of significant disturbances in hemostatic processes were detected in the sheep tested.

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“…The aspiration to use Hap for the treatment of damaged organs or bones has prompted researchers to expand research on this biomaterial [1][2][3][4]. Owing to its very special properties like biocompatibility, bioactivity, osteoconductivity, nontoxicity, bone healing function etc., Hap is being used in the field of biomedical research [5][6][7][8][9][10][11][12][13]. It has also found other notable applications in chromatography, biosensors, gas sensor, catalysts, fuel cells, adsorbents, etc.…”

Section: Introductionmentioning

confidence: 99%

Coupled effect of particle size of the source materials and calcination temperature on the direct synthesis of hydroxyapatite

et al. 2021

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We report the effect of controlled particle size (obtained by using 80, 100, 120, 140 and 200 mesh) of the source materials on the synthesis of a well-known biomaterial, hydroxyapatite (Hap). In addition to this, we have also mapped the consequence of applied temperature (700°C, 800°C and 900°C) on the crystallographic properties and phase composition of the obtained Hap. Nevertheless, although with Hap, in each case, β-tricalcium phosphate (β-TCP) was registered as the secondary phase the ANOVA test revealed that the results of the crystallographic parameters are significantly different for the applied sintering temperature 700°C and 800°C ( p < 0.05), while the data obtained for calcination temperature 800°C are not significantly different from that acquired at 900°C ( p > 0.05). Fourier transform infrared spectrophotometer data ensured that, irrespective of mesh size and calcination temperature, the synthesized Hap samples were of carbonated apatite with B-type substitution. Interestingly, for all cases, the % of carbonate content was below the maximum limit (8%) of the CO 3 2 − ion present in bone tissue hydroxyapatite.

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Hydroxyapatite: a promising hemostatic component in orthopaedic applications

Cited by 5 publications

References 21 publications

Hydroxyapatite: Preparation, Properties and Its Biomedical Applications

Hydroxyapatite: Preparation, Properties and Its Biomedical Applications

Parameters of Hemostasis in Sheep Implanted with Composite Scaffold Settled by Stimulated Mesenchymal Stem Cells—Evaluation of the Animal Model

Coupled effect of particle size of the source materials and calcination temperature on the direct synthesis of hydroxyapatite

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