Hydroxyapatite coating for control degradation and parametric optimization of pure magnesium: an electrophoretic deposition technique for biodegradable implants

Akram, Waseem; Khan, Rafiullah; Petrů, Michal; Amjad, Muhammad; Ahmad, Khalil; Yasir, Muhammad; Ahmad, Sajjad; Koloor, Seyed Saeid Rahimian

doi:10.1016/j.jmrt.2023.08.026

Cited by 7 publications

(5 citation statements)

References 57 publications

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“…Coating of implant surfaces with biodegradable polymers (e.g., poly(lactic acid)) is also shown to be an effective strategy to act as a barrier to corrosion. Surface treatment of implants is also performed with compounds having biological activity in order to enhance compatibility with the surrounding tissue. , There are several reports in the literature on the surface modification of Mg-based implants with bioactive coatings. For example, in the study of Gao et al, Mg-based implants were produced and coated with CaP without any ion doping, and delayed degradation was observed.…”

Section: Discussionmentioning

confidence: 99%

MgCa-Based Alloys Modified with Zn- and Ga-Doped CaP Coatings Lead to Controlled Degradation and Enhanced Bone Formation in a Sheep Cranium Defect Model

Gokyer,

Monsef,

Buyuksungur

et al. 2024

ACS Biomater. Sci. Eng.

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Mg-based biodegradable metallic implants are gaining increased attraction for applications in orthopedics and dentistry. However, their current applications are hampered by their high rate of corrosion, degradation, and rapid release of ions and gas bubbles into the physiological medium. The aim of the present study is to investigate the osteogenic and angiogenic potential of coated Mg-based implants in a sheep cranial defect model. Although their osteogenic potential was studied to some extent, their potential to regenerate vascularized bone formation was not studied in detail. We have studied the potential of magnesium−calcium (MgCa)-based alloys modified with zinc (Zn)-or gallium (Ga)-doped calcium phosphate (CaP) coatings as a strategy to control their degradation rate while enhancing bone regeneration capacity. MgCa and its implants with CaP coatings (MgCa/CaP) as undoped or as doped with Zn or Ga (MgCa/CaP + Zn and MgCa/CaP + Ga, respectively) were implanted in bone defects created in the sheep cranium. MgCa implants degraded faster than the others at 4 weeks postop and the weight loss was ca. 50%, while it was ca. 15% for MgCa/CaP and <10% in the presence of Zn and Ga with CaP coating. Scanning electron microscopy (SEM) analysis of the implant surfaces also revealed that the MgCa implants had the largest degree of structural breakdown of all the groups. Radiological evaluation revealed that surface modification with CaP to the MgCa implants induced better bone regeneration within the defects as well as the enhancement of bone−implant surface integration. Bone volume (%) within the defect was ca. 25% in the case of MgCa/CaP + Ga, while it was around 15% for undoped MgCa group upon micro-CT evaluation. This >1.5-fold increase in bone regeneration for MgCa/CaP + Ga implant was also observed in the histopathological examination of the H&E-and Masson's trichrome-stained sections. Immunohistochemical analysis of the bone regeneration (antiosteopontin) and neovascularization (anti-CD31) at the defect sites revealed >2-fold increase in the expression of the markers in both Ga-and Zn-doped, CaP-coated implants. Zn-doped implants further presented low inflammatory reaction, notable bone regeneration, and neovascularization among all the implant groups. These findings indicated that Ga-and Zn-doped CaP coating is an important strategy to control the degradation rate as well as to achieve enhanced bone regeneration capacity of the implants made of Mg-based alloys.

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Section: Discussionmentioning

confidence: 99%

MgCa-Based Alloys Modified with Zn- and Ga-Doped CaP Coatings Lead to Controlled Degradation and Enhanced Bone Formation in a Sheep Cranium Defect Model

Gokyer,

Monsef,

Buyuksungur

et al. 2024

ACS Biomater. Sci. Eng.

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“…Grain refined microstructure and presence of HAp particles were responsible for facilitating the formation of bone-like HAp crystals [21]. Akram W. et al [22] deposited hydroxyapatite on biodegradable pure magnesium. The coatings were analyzed for surface quality, surface roughness, corrosion resistance, and coating adhesion.…”

Section: Introductionmentioning

confidence: 99%

“…The adhesion to the substrate and wear of the coating are sufficient for the intended biomedical applications. Additionally, the corrosion resistance of magnesium was significantly improved after electrophoretic deposition of hydroxyapatite on it [22].…”

Section: Introductionmentioning

confidence: 99%

“…There are numerous deposition methods of hydroxyapatite coatings on metallic substrates, e.g., sol-gel, plasma spraying, RF magnetron sputter, pulse laser deposition, electrophoretic deposition, and electrolytic deposition [14,26]. The most popular technique is an electrophoretic deposition [1,[22][23][24][25][26][27][28]. The EPD technique has the following advantages: low cost of equipment, coating thickness control, simplicity of the process, capability of coating complex and uniform substrates, and small amount of time needed to obtain the coating [14,29].…”

Section: Introductionmentioning

confidence: 99%

“…Polyethylenimine (PEI) can also be used as a dispersing agent [14]. W. Akram et al [22] used magnetic stirring and ultrasonication, and lowered the pH to 3.5 using acetic acid to obtain a stable suspension [22]. When HAp nanoparticles were suspended in ethanol, agglomerates of HAp nanoparticles were observed on all surfaces [19,33,34].…”

Section: Introductionmentioning

confidence: 99%

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Study of Nanohydroxyapatite Coatings Prepared by the Electrophoretic Deposition Method at Various Voltage and Time Parameters

Malisz,

Świeczko-Żurek,

Olive

et al. 2024

Materials

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The aim of the work is to compare the properties of nanohydroxyapatite coatings obtained using the electrophoretic deposition method (EDP) at 10 V, 20 V, and 30 V, and with deposit times of 2 and 5 min. The primary sedimentation was used to minimize the risk of the formation of particle agglomerates on the sample surface. Evaluation of the coating was performed by using a Scanning Electron Microscope (SEM), Energy-Dispersive Spectroscopy (EDS), Atomic Force Microscopy (AFM), optical profilometer, drop shape analyzer, and a nanoscratch tester. All of the coatings are homogeneous without any agglomerates. When low voltage (10 V) was used, the coatings were uniform and continuous regardless of the deposition time. The increase in voltage resulted in the formation of cracks in the coatings. The wettability test shows the hydrophilic behavior of the coatings and the mean contact angle values are in the range of 20–37°. The coatings showed excellent adhesion to the substrate. The application of a maximum force of 400 mN did not cause delamination in most coatings. It is concluded that the optimal coating for orthopedic implants (such as hip joint implants, knee joint implants or facial elements) is obtained at 10 V and 5 min because of its homogeneity, and a contact angle that promotes osseointegration and great adhesion to the substrate.

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The effect of hydroxyapatite on the morphology and corrosion behavior of chitosan/gelatine-reduced functionalized graphene oxide coating on 316 stainless steel

Mohammadzadeh,

Jafari,

Khaleqpasand

et al. 2024

J Aust Ceram Soc

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Hydroxyapatite coating for control degradation and parametric optimization of pure magnesium: an electrophoretic deposition technique for biodegradable implants

Cited by 7 publications

References 57 publications

MgCa-Based Alloys Modified with Zn- and Ga-Doped CaP Coatings Lead to Controlled Degradation and Enhanced Bone Formation in a Sheep Cranium Defect Model

MgCa-Based Alloys Modified with Zn- and Ga-Doped CaP Coatings Lead to Controlled Degradation and Enhanced Bone Formation in a Sheep Cranium Defect Model

Study of Nanohydroxyapatite Coatings Prepared by the Electrophoretic Deposition Method at Various Voltage and Time Parameters

The effect of hydroxyapatite on the morphology and corrosion behavior of chitosan/gelatine-reduced functionalized graphene oxide coating on 316 stainless steel

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