Hydroxyapatite coatings on Mg-Ca alloy prepared by Pulsed Laser Deposition: Properties and corrosion resistance in Simulated Body Fluid

Rau, Julietta V.; Antoniac, Iulian; Filipescu, M.; Cotruț, Cosmin Mihai; Fosca, Marco; Nistor, L. C.; Bı̂rjega, R.; Dinescu, M.

doi:10.1016/j.ceramint.2018.06.095

Cited by 50 publications

(26 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Calcium phosphates (CaP) coatings are commonly applied on the surface of bio-inert metallic bone implants and prosthetic devices to accelerate the formation of new bone and establish a firm bonding between the implant and the growing bone [1]. In particular, CaP thin films (thickness < 1 μm) are raising attention [2][3][4] compared to traditional, thick (> 30 μm), sprayed coatings due to a higher mechanical stability, lower tendency to cracking and delamination [5] and the possibility of obtaining a nanostructured surface texture able to boost platelet, protein and cell adhesion [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of biomimetic hydroxyapatite thin films for bone implants by direct ablation of a biogenic source

Graziani

Berni

Gambardella

et al. 2019

Materials Science and Engineering: C

View full text Add to dashboard Cite

Biomimetic bone apatite coatings were realized for the first time by the novel Ionized Jet Deposition technique. Bone coatings were deposited on titanium alloy substrates by pulsed electron ablation of deproteinized bovine bone shafts in order to resemble bone apatite as closely as possible. The composition, morphology and mechanical properties of the coatings were characterized by GI-XRD, FT-IR, SEM-EDS, AFM, contact angle measurements, micro-scratch and screw-insertion tests. Different post-treatment annealing conditions (from 350°C to 425°C) were investigated. Bone apatite coatings exhibited a nanostructured surface morphology and a composition closely resembling that of the deposition target (i.e. natural bone apatite), also regarding the presence of magnesium and sodium ions. Crystallinity and composition of the coatings were strongly influenced by annealing temperature and duration; in particular, upon annealing at 400°C and above, a crystallinity similar to that of bone was achieved. Finally, adhesion to the titanium substrate and hydrophilicity were significantly enhanced upon annealing, all characteristics being known to have a strong positive impact on promoting host cells attachment, proliferation and differentiation. 2− , Sr + , K + , etc.) [14,15]. In turn, suitable ion release can trigger stem cells homing and their osteogenic differentiation commitment, thus

show abstract

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of biomimetic hydroxyapatite thin films for bone implants by direct ablation of a biogenic source

Graziani

Berni

Gambardella

et al. 2019

Materials Science and Engineering: C

View full text Add to dashboard Cite

show abstract

“…Furthermore, in vitro tests showed no potential cytotoxic effects, but a promotion of cell growth. Rau et al (2018) deposited a HA coating on a Mg-Ca alloy in order to obtained a controllable in vitro degradation process, and the results showed a good corrosion in SBF, suggesting a promising potential for the developed coatings. In recent years, an attempt to replace HA coatings with fluorinate hydroxyapatite (FHA), in the field of medical devices, has been made.…”

Section: Surface Coatingsmentioning

confidence: 99%

In vitro and in vivo biological performance of Mg-based bone implants

Negrescu¹,

Necula²,

Costache³

et al. 2020

Rev. Biol. Biomed. Sci.

View full text Add to dashboard Cite

With the rapid advancement of medical technology, it is crucial that a considerable body of biomaterials are taken into consideration and tested for the purpose of bone implant fabrication. Over the last decades degradable metallic materials have attracted increasing interest in the field of hard tissue engineering due to their ability to degrade once they have fulfilled their function, without causing side effects that could potentially be harmful for the human body. In this context, Mg-based biomaterials gained special attention due to their bone-like mechanical properties, good biocompatibility and osteoconductive properties. However, their use in biomedical applications is limited due to their rapid corrosion in physiological environments. Therefore, it is important to reduce the degradation process of these biomaterials for safe biomedical applications. Two main strategies that could potentially lead to a lower corrosion rate are represented by alloying and surface treatment. This review provides a summary of the recent specialized literature concerning Mg-based biomaterials with a special focus on the recent in vitro and in vivo studies regarding Mg-based bone implants.

show abstract

“…This technique presents numerous advantages that makes it suitable to process biocompatible materials for biological applications. [ 33 ]…”

Section: Introductionmentioning

confidence: 99%

Iron Ion‐Doped Tricalcium Phosphate Coatings Improve the Properties of Biodegradable Magnesium Alloys for Biomedical Implant Application

Antoniac

Filipescu

Barbaro

et al. 2020

Adv Materials Inter

View full text Add to dashboard Cite

Iron‐substituted tricalcium phosphate (Fe‐TCP) (about 1 wt%) coatings are deposited on biodegradable Mg‐Ca alloys to improve their corrosion resistance. Pulsed laser deposition technique is used for coating preparation. The 2 µm thick coatings are uniformly deposited. (Ca+Fe)/P ratio for the Fe‐TCP coatings is close to the stoichiometric value. Coated and uncoated Mg‐Ca alloys are subjected to electrochemical tests to investigate the influence of the coatings on their corrosion resistance in simulated body fluid (SBF). Tafel curves corresponding to coated and uncoated Mg‐Ca alloy samples in SBF show that the most electropositive corrosion potential is reached for the Fe‐TCP‐coated Mg‐Ca deposited at 300 °C. From the obtained and calculated values of the electrochemical parameters it follows that this sample possesses the best characteristics: it has the smallest porosity and the highest protective efficiency in SBF. Equine adipose tissue‐derived mesenchymal stem cells are used for 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide test and osteogenic differentiation study. Microbiology tests are performed with Escherichia coli (E. coli) (Gram−) and Staphylococcus aureus (Gram+) bacteria strains. The Fe‐TCP‐coated Mg‐Ca deposited at 300 °C is characterized by the best cytocompatibility and good ability to inhibit the growth of E. coli and is recommended for biomedical implant applications.

show abstract

Hydroxyapatite coatings on Mg-Ca alloy prepared by Pulsed Laser Deposition: Properties and corrosion resistance in Simulated Body Fluid

Cited by 50 publications

References 56 publications

Fabrication and characterization of biomimetic hydroxyapatite thin films for bone implants by direct ablation of a biogenic source

Fabrication and characterization of biomimetic hydroxyapatite thin films for bone implants by direct ablation of a biogenic source

In vitro and in vivo biological performance of Mg-based bone implants

Iron Ion‐Doped Tricalcium Phosphate Coatings Improve the Properties of Biodegradable Magnesium Alloys for Biomedical Implant Application

Contact Info

Product

Resources

About