Hydroxyapatite coatings on Ti produced by hot isostatic pressing

Herø, H.; Wie, Henrik; Jørgensen, R.B.; Ruyter, I. Eystein

doi:10.1002/jbm.820280308

Cited by 87 publications

(47 citation statements)

References 9 publications

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“…Some of the coating methods of the first approach include electrophoretic deposition (Ducheyne et al 1990), plasma spraying (De Groot et al 1990;Thull & Grant 2001), radio frequency or ionic ray sputtering (Cook et al 1988), laser ablation (Clèries 1999;Serra et al 2001) or hot isostatic pressure (Hero et al 1994). None of these methods produce covalent links with the substrate, and the majority are not cost-effective.…”

Section: Metalsmentioning

confidence: 99%

Biomaterials in orthopaedics

Navarro

Michiardi

Castaño

et al. 2008

J. R. Soc. Interface.

1,289

730

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At present, strong requirements in orthopaedics are still to be met, both in bone and joint substitution and in the repair and regeneration of bone defects. In this framework, tremendous advances in the biomaterials field have been made in the last 50 years where materials intended for biomedical purposes have evolved through three different generations, namely first generation (bioinert materials), second generation (bioactive and biodegradable materials) and third generation (materials designed to stimulate specific responses at the molecular level). In this review, the evolution of different metals, ceramics and polymers most commonly used in orthopaedic applications is discussed, as well as the different approaches used to fulfil the challenges faced by this medical field.

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Section: Metalsmentioning

confidence: 99%

Biomaterials in orthopaedics

Navarro

Michiardi

Castaño

et al. 2008

J. R. Soc. Interface.

1,289

730

View full text Add to dashboard Cite

show abstract

“…Numerous efforts have been made to enhance the surface roughness of conventional titanium/alloy implants, including electrophoretic deposition, 2 sputtering 3 or hot pressing. 4 It is found that the surface roughness fabricated by these methods is limited to the micrometer scale, but the samples are featureless at the nanoscale. 5 Recently, it has been reported that surfaces with nano features, either disordered 6,7 or ordered (e.g.…”

Section: Introductionmentioning

confidence: 99%

Ordered nano-scale dimple pattern formation on a titanium alloy (Ti-6Al-4V)

2012

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Due to the many applications of nanostructured surfaces – including in biomaterials – there is a strong interest in cost- and time-efficient methods for their fabrication. Previously, our group established a simple electrochemical method generating nanoscale patterns on large areas of a number of different metal surfaces. They consist of dimples that are around 6-10 nm deep and hexagonally closed packed with a tunable periodicity of around 50 nm. Ordering requires careful tuning of the surface chemistry, which makes the translation of these findings to multi-component alloys non-obvious. Here, we demonstrate for the first time that such a pattern can also be achieved on the surface of an alloy, namely Ti-6Al-4V. This alloy is of particular interest for biomedical implants. While dimple formation on the main component metals titanium and aluminum has previously been reported (albeit under conditions that differ from each other), we now also report dimple formation on pure vanadium surfaces to occur under very different conditions. Dimple formation occurs preferentially on the (dominant) α-phase grains of the alloy. The size of dimples of the alloy material is subject to the electropolishing potential, electrolyte concentration and surface chemical composition, which gives us the opportunity to control the surface features. Since a main application of this alloy are biomedical implants, this level of control will be an important tool for accommodating cell growth

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“…In the last decades, several surface modifications have been employed which alter one or more of these properties in an attempt to achieve more favorable bone responses. Some techniques such as plasma spraying [2], laser deposition [3], ion beam dynamic mixing [4], ion beam deposition [5], magnetron sputtering [6], hot isostatic pressing [7], electrophoretic deposition [8], sol-gel [9], ion implantation [10], NaOH treatment [11] and electrochemical methods [12], have been employed to coat hydroxyapatite (HA) or other calcium phosphate on the surface of Ti. However, each method has some disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Surface characteristics and osteoblast cell response on TiN- and TiAlN-coated Ti implant

Jang¹,

Ha²,

Kim³

et al. 2011

Biomed. Eng. Lett.

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Purpose The purpose of this study was to evaluate the surface characteristics and osteoblast cell response of TiN and TiAlN coated on Ti Surface. Methods TiN and TiAlN coatings were applied on Ti dental implant and surface characteristics of these coatings were evaluated. And osteogenic effect of TiN and TiAlN coating on MG63 osteoblast-like cell proliferation and differentiation was evaluated by cell viability assay (MTT assay), ALP activity assay and expressions of collagen gene. Results As observed by SEM, both the TiN and TiAlN coatings had thickness of about 1.7 µm. From the EDX analysis, Ti and N peaks and Ti, Al and N peaks are confirmed on the TiN and TiAlN coating surface, respectively. The wetting angles of TiN and TiAlN coatings were increased as compared to that of control Ti. As compared to Ti, a great number of attached cells on TiN and TiAlN coated surfaces were observed. The cell survival rate of the TiN and TiAlN were 125% and 117% as compared to that of the Ti (100%). Both the TiN and TiAlN coatings produced equivalent levels of protein. ALP activity of MG63 cells grown on Ti, TiN and TiAlN surface is indicated. Collagen gene was overexpressed in cells cultured on TiN and TiAlN in comparison with the Ti.Conclusions TiN and TiAlN coatings on Ti dental implant may have potential for use in dental implant in terms of their biocompatibility.

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Hydroxyapatite coatings on Ti produced by hot isostatic pressing

Cited by 87 publications

References 9 publications

Biomaterials in orthopaedics

Biomaterials in orthopaedics

Ordered nano-scale dimple pattern formation on a titanium alloy (Ti-6Al-4V)

Surface characteristics and osteoblast cell response on TiN- and TiAlN-coated Ti implant

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