Hydroxyapatite composite scaffold for bone regeneration via rapid prototyping technique: a review

Sun, Fangfang; Wang, Tianze; Yang, Yong

doi:10.1108/rpj-09-2020-0224

Cited by 6 publications

(3 citation statements)

References 105 publications

(104 reference statements)

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“…In addition, researchers also reported that PLA/nHAP is capable to enhance the osteo‐inductivity and osteo‐conductivity 32 . In vitro studies performed with PLA/nHAp revealed that cell adhesion and proliferation on the surface of the developed biocomposite support the biocompatible nature 25,33 . Thus, the PLA/nHAp biocomposite and membrane 34,35 is helpful in bone tissue repair.…”

Section: Introductionmentioning

confidence: 97%

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Nano‐hydroxyapatite reinforced polylactic acid bioabsorbable cancellous screws for bone fracture fixations

Prasad,

Bhasney,

Prasannavenkadesan

et al. 2023

J of Applied Polymer Sci

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Bioabsorbable polymer implants aid the fracture treatment to overcome the limitations of metallic implants like stress shielding, corrosion, and revision surgeries. The cancellous screw is one of the internal fixation implants more frequently used in fixation procedures. In this work, nano‐hydroxyapatite (nHAp) reinforced polylactic acid cancellous screws were developed for bone fracture treatment. The biocompatibility and mechanical tests were performed before and after in‐vitro hydrolytic degradation studies. The addition of nanofillers (10 wt% nHAp) enhanced the pullout strength, torsional strength, and shear strength by 18%, 48%, and 5%, respectively. The performed thermal studies confirmed that the nanohydroxyapatite facilitates the crystallization process. A mass loss of about 18% in the case of neat PLA and 12% in the case of 10 wt% nHAp was observed for 90 days of in‐vitro hydrolytic degradation studies. So, the developed combination of biocomposite could help fabricate patient‐specific bioabsorbable fixation devices like screws and plates.

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Section: Introductionmentioning

confidence: 97%

“…32 In vitro studies performed with PLA/nHAp revealed that cell adhesion and proliferation on the surface of the developed biocomposite support the biocompatible nature. 25,33 Thus, the PLA/nHAp biocomposite and membrane 34,35 is helpful in bone tissue repair.…”

Section: Introductionmentioning

confidence: 99%

Nano‐hydroxyapatite reinforced polylactic acid bioabsorbable cancellous screws for bone fracture fixations

Prasad,

Bhasney,

Prasannavenkadesan

et al. 2023

J of Applied Polymer Sci

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“…Bone tissue engineering is performed by constructing the three components of artificial bone material, bone cells, and the growth factors required by the cells into a composite and implanting them into the body to reconstruct the tissue externally, internally, and functionally [ 1 ]. At present, the main artificial bones on the market are made of metal materials, bioceramics, and polymer materials.…”

Section: Introductionmentioning

confidence: 99%

3D Printing and Performance Study of Porous Artificial Bone Based on HA-ZrO2-PVA Composites

Bie¹,

Chen

Shan

et al. 2023

Materials

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An ideal artificial bone implant should have similar mechanical properties and biocompatibility to natural bone, as well as an internal structure that facilitates stomatal penetration. In this work, 3D printing was used to fabricate and investigate artificial bone composites based on HA-ZrO2-PVA. The composites were proportionally configured using zirconia (ZrO2), hydroxyapatite (HA) and polyvinyl alcohol (PVA), where the ZrO2 played a toughening role and PVA solution served as a binder. In order to obtain the optimal 3D printing process parameters for the composites, a theoretical model of the extrusion process of the composites was first established, followed by the optimization of various parameters including the spray head internal diameter, extrusion pressure, extrusion speed, and extrusion line width. The results showed that, at the optimum parameters of a spray head diameter of 0.2 mm, extrusion pressure values ranging from 1–3 bar, a line spacing of 0.8–1.5 mm, and a spray head displacement range of 8–10 mm/s, a better structure of biological bone scaffolds could be obtained. The mechanical tests performed on the scaffolds showed that the elastic modulus of the artificial bone scaffolds reached about 174 MPa, which fulfilled the biomechanical requirements of human bone. According to scanning electron microscope observation of the scaffold sample, the porosity of the scaffold sample was close to 65%, which can well promote the growth of chondrocytes and angiogenesis. In addition, c5.18 chondrocytes were used to verify the biocompatibility of the composite materials, and the cell proliferation was increased by 100% when compared with that of the control group. The results showed that the composite has good biocompatibility.

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Tailored material for bioresorbable internal fixation devices: a novel approach using nanohydroxyapatite and chitosan in polylactic acid

Bose,

Prasannavenkadesan,

Katiyar

2023

J Mater Sci

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Hydroxyapatite composite scaffold for bone regeneration via rapid prototyping technique: a review

Cited by 6 publications

References 105 publications

Nano‐hydroxyapatite reinforced polylactic acid bioabsorbable cancellous screws for bone fracture fixations

Nano‐hydroxyapatite reinforced polylactic acid bioabsorbable cancellous screws for bone fracture fixations

3D Printing and Performance Study of Porous Artificial Bone Based on HA-ZrO2-PVA Composites

Tailored material for bioresorbable internal fixation devices: a novel approach using nanohydroxyapatite and chitosan in polylactic acid

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