Hydroxyapatite formation from a hydrated calcium monohydrogen phosphate precursor

Francis, Marion D.; Webb, Ned C.

doi:10.1007/bf02196214

Cited by 188 publications

(71 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6. As shown in the figure, the Ca/P ratio for the apatite obtained by the subcritical water and alkaline hydrothermal methods were 1.56 and 1.86, respectively these values lie within the acceptable range for the hydroxyapatite [45]. Variation of these values than the standard HAp value might be due to implication of the carbonate group in the apatites obtained by those methods.…”

Section: Edx Resultsmentioning

confidence: 54%

Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: Extraction of biologically desirable HAp

Barakat

Khalil

Sheikh

et al. 2008

Materials Science and Engineering: C

169

View full text Add to dashboard Cite

Section: Edx Resultsmentioning

confidence: 54%

Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: Extraction of biologically desirable HAp

Barakat

Khalil

Sheikh

et al. 2008

Materials Science and Engineering: C

169

View full text Add to dashboard Cite

“…Our restults showing lack of a linear relationship between 99mTc-P uptake and total tissue calcium concentration are consistent with available data regarding the interaction of 99mTc-P agents with various forms of tissue calcium stores. It is now appreciated that initial stages of calcium accumulation and calcification involve accumulation of calcium from plasma followed by precipitation of calcium phosphate in the form of amorphous (noncrystalline) and relatively soluble deposits with very high surface to volume ratio (24,25,45). Subsequently, nonreversible hydrolysis of amorphous calcium phosphate results in the formation of insoluble, crystalline hydroxyapatite which undergoes progressive crystal growth into spicular deposits and progressive reduction in surface to volume ratio as the crystals enlarge (45).…”

Section: Concentration Of Technetium-99m Phosphorus Agents 731mentioning

confidence: 99%

Sites and Mechanisms of Localization of Technetium-99m Phosphorus Radiopharmaceuticals in Acute Myocardial Infarcts and other Tissues

Buja¹,

Tofe²,

Kulkarni³

et al. 1977

J. Clin. Invest.

Self Cite

205

View full text Add to dashboard Cite

A B S T R A C T This study was performed to elucidate the localization at the cellular level of technetium-99m phosphorus (991'Tc-P) radiopharmaceuticals in acute myocardial infarcts and the mechanisms responsible for 99mTc-P uptake in acute myocardial infarcts and other tissues. In 20 dogs with proximal left anterior descending coronary arterial ligation for 1-3 days, elevated calcium levels were measured at all sites of increased 99mTc-P uptake (acute myocardial infarcts, necrotic thoracotomy muscle, lactating breast, and normal bone); however, a consistent linear relationship between 99mTc-P and calcium levels was not observed. A strong correlation (r = 0.95 and 0.99, n = 2 dogs) was demonstrated between levels of 3H-diphosphonate and 99mTc-P in infarcted myocardium. Auito studies revealed major localization of both 99mTc-P and calcium in the soluble supernate and membranedebris fractions of infarcted myocardium and less than 2% of total 99mTc-P and calcium in the mitochondrial fractions; however, electron microscopic examination showed that mitochondria with calcific deposits were not preserved in the mitochondrial fractions. In vitro studies evaluating the role of serum protein binding on tissue uptake of 99mTc-P agents demonstrated that, in spite of significant complexing with serum proteins, serum 99mTc-P activity retained the ability to adsorb to calcium hydroxyapatite and amorphous calciumni phosphate. In vivo stuidies showed that concentration of human seirum albtumin (labeled with iodine-131) in infarcted myocardiutim reached a maximuiim of only 3.8 times normal after a circulation time of 96 h, whereas 99mTc-P uiptake was at least 10 times normal after a circulation time as short as 1 h. It is concluded that: (a) 99mTc-P uptake in acutely infarcted myocardium, and possibly other types of soft tissue damage, is limited to necrotic and severely injured cells; (b) concentration of 99mTc-P results from selective adsorption of 99mTc-P with various forms of tissue calcium stores, including amorphous calcium phosphate, crystalline hydroxyapatite, and calcium complexed with myofibrils and other macromolecules, possibly supplemented by calcium-independent complexing with organic macromolecules; and (c) lack of a linear relationship between 99mTc-P and tissuie calcitum levels mainly results from local differences in composition and physicochemical properties of tissuie calcium stores and from local variations in levels of blood flow f'or delivery of 99mTc-P agents.

show abstract

“…DCPD is the CaP that can be most easily synthesized. It has been detected in fracture callus [32], bone [38], and kidney stones [47] and is also sometimes considered to be a precursor of HA in bone [20]. DCPD is biocompatible and osteoconductive.…”

mentioning

confidence: 99%

Physical and chemical aspects of calcium phosphates used in spinal surgery

Bohner¹

2002

The Use of Bone Substitutes in Spine Surgery

View full text Add to dashboard Cite

Hydroxyapatite formation from a hydrated calcium monohydrogen phosphate precursor

Cited by 188 publications

References 18 publications

Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: Extraction of biologically desirable HAp

Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: Extraction of biologically desirable HAp

Sites and Mechanisms of Localization of Technetium-99m Phosphorus Radiopharmaceuticals in Acute Myocardial Infarcts and other Tissues

Physical and chemical aspects of calcium phosphates used in spinal surgery

Contact Info

Product

Resources

About