Hydroxyapatite nanoparticles (HAP NPs): a green and efficient heterogeneous catalyst for three-component one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in aqueous media

Abstract

HAP NPs were applied as a green heterogeneous catalyst for synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives. The nanocatalyst was prepared and characterized.

KCC-1/Pr-SO3H: an efficient heterogeneous catalyst for green and one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one

“…We also observed that 4-pyrazoloaniline [32] which synthesized for prepare of our newly desired 2,3-dihydroquinazolin-4(1H)-one was well tolerated under our reaction conditions with 95% isolated yield (4o). [33], the possible mechanism for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from the three-component condensation of isatoic anhydride (1), aromatic amines (2), and aromatic aldehydes (4) in the presence of KCC-1/Pr-SO 3 H has been shown in Scheme 3. As can be seen, at first stage the acidic sites of the catalyst activated the carbonyl group of isatoic anhydride.…”

Advances in Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

“…4) [35,45 ～ 48] .该方法是由靛红酸酐合成 2,3-二氢喹啉- [35,45～48] . 图式 靛红酸酐与胺、醛/酮分步反应 Scheme 8 Stepwise reaction of isatoic anhydrides with amines and aldehydes/ketones "一锅法"的三组分串联反应生成 2,3-二氢喹啉-4(1H)-酮的机理如 Scheme 9 所示 [35,46,47] .首先, 靛红酸 [49,50] ; 无溶剂条件下, 该反应各原料在 NaOH 存在下在研钵中研磨均匀后再 转移入反应瓶中加热反应 30 min, 即可以 80%～96%的 收率得到目标产物(Eq. 5) [51] .…”

Synthesis and characterization of nanocrystalline hydroxyapatite and its catalytic behavior towards synthesis of 3,4‐disubstituted isoxazole‐5(4H)‐ones in water

“…Hydroxyapatite, one of the most important inorganic biomaterials, has extensive applications in drug delivery systems, bone grafts, catalysts and adsorbents because of its high specific surface area, low water solubility, availability, low cost and high stability.…”

“…In fact, green chemistry is a term given to 12 principles, and following these principles makes a process and its reactions environmentally friendly and healthy performing, reduces the risk of toxic substances, lowers energy consumption, and enhances the efficiency up to a maximum. [11][12][13] Hydroxyapatite, one of the most important inorganic biomaterials, has extensive applications in drug delivery systems, [14] bone grafts, [15,16] catalysts [17] and adsorbents [18] because of its high specific surface area, low water solubility, availability, low cost and high stability.…”