Hydroxyapatite nanorods loaded with parathyroid hormone (PTH) synergistically enhance the net formative effect of PTH anabolic therapy

Dave, Jay R.; Dewle, Ankush; Mhaske, Suhas T.; Phulpagar, Prashant; Mathe, V. L.; More, Supriya E.; Khan, Ayesha; Murthy, Appala Venkata Ramana; Datar, Suwarna; Jog, Ajay; Page, Megha; Tomar, Geetanjali B.

doi:10.1016/j.nano.2018.10.003

Cited by 20 publications

(11 citation statements)

References 30 publications

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“…Therefore, in order to increase bone mineral content, PTH has been conjugated with different carriers. An example involves its adsorption to hydroxyapatite nanorods that possess enhanced affinity to the calcium present in the bone, to specifically release the hormone in the osteoporotic bone [89]. In vitro and in vivo results confirmed the synergistic effect of PTH and hydroxyapatite, with enhanced osteogenesis and bone regeneration in an OVX mice model.…”

Section: Osteoporosismentioning

confidence: 86%

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Lima

Ferreira

Reis

et al. 2019

Expert Opinion on Drug Delivery

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Introduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice.

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Section: Osteoporosismentioning

confidence: 86%

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Lima

Ferreira

Reis

et al. 2019

Expert Opinion on Drug Delivery

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“…As drug carriers, CBNMs have high drug loading capacity and are easily prepared and functionalized. Nanostructured CaPs are the most commonly used CBNMs; because −OH groups and Ca 2+ cations are abundant on their surfaces, they can effectively adsorb organic molecules with acid groups such as carboxylic and phosphoric groups, giving them exceptionally high drug loading capacity. ,,− Mesoporous bioactive glasses (MBGs) are representative of nanostructured CaSi. MBGs have not only Ca 2+ cations on their surface but also a high specific surface area and large pore volume, making them especially effective in adsorbing drug molecules to facilitate delivery. ,− …”

Section: Cbnms For Osteoporosis Treatmentmentioning

confidence: 99%

“…Various methods can be applied to prepare and functionalize CBNMs, including a simple, mild liquid-phase mineralization reaction. ,,− This provides an opportunity to achieve uniform nanomorphology and diversified functionalization of CBNMs using many hydrophilic drugs and organic ingredients via mineralization reactions. CBNMs, especially CaP, are also structurally able to accept many ionic substitutions, such as strontium, ,− cobalt, boron and europium .…”

Section: Cbnms For Osteoporosis Treatmentmentioning

confidence: 99%

Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment

Deng

Wei

Tang

2022

ACS Biomater. Sci. Eng.

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With rapidly aging populations worldwide, osteoporosis has become a serious global public health problem. Caused by disordered systemic bone remodeling, osteoporosis manifests as progressive loss of bone mass and microarchitectural deterioration of bone tissue, increasing the risk of fractures and eventually leading to osteoporotic fragility fractures. As fracture risk increases, antiosteoporosis treatments transition from nonpharmacological management to pharmacological intervention, and finally to the treatment of fragility fractures. Calcium-based nanomaterials (CBNMs) have unique advantages in osteoporosis treatment because of several characteristics including similarity to natural bone, excellent biocompatibility, easy preparation and functionalization, low pH-responsive disaggregation, and inherent pro-osteogenic properties. By combining additional ingredients, CBNMs can play multiple roles to construct antiosteoporotic biomaterials with different forms. This review covers recent advances in CBNMs for osteoporosis treatment. For ease of understanding, CBNMs for antiosteoporosis treatment can be classified as locally applied CBNMs, such as implant coatings and filling materials for osteoporotic bone regeneration, and systemically administered CBNMs for antiosteoporosis treatment. Locally applied CBNMs for osteoporotic bone regeneration develop faster than the systemically administered CBNMs, an important consideration given the serious outcomes of fragility fractures. Nevertheless, many innovations in construction strategies and preparation methods have been applied to build systemically administered CBNMs. Furthermore, with increasing interest in delaying osteoporosis progression and avoiding fragility fracture occurrence, research into systemic administration of CBNMs for antiosteoporosis treatment will have more development prospects. Deep understanding of the CBNM preparation process and optimizing CBNM properties will allow for increased application of CBNMs in osteoporosis treatments in the future.

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“…Simultaneously, they have also been studied for drug delivery due to their ease of functionalization (Perez-Juste et al, 2005;Smith et al, 2009). Calcium phosphate nanorods, mainly hydroxyapatite, have been used both as nanocarriers and for bone tissue regeneration in composite scaffolds (Rubin et al, 2003;Nga et al, 2014;Dave et al, 2019;Li et al, 2019;Nakayama et al, 2019).…”

Section: Defining Nanostructuresmentioning

confidence: 99%

Modern World Applications for Nano-Bio Materials: Tissue Engineering and COVID-19

Melchor-Martínez

Castillo

Macías-Garbett

et al. 2021

Front. Bioeng. Biotechnol.

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Over the past years, biomaterials-based nano cues with multi-functional characteristics have been engineered with high interest. The ease in fine tunability with maintained compliance makes an array of nano-bio materials supreme candidates for the biomedical sector of the modern world. Moreover, the multi-functional dimensions of nano-bio elements also help to maintain or even improve the patients’ life quality most securely by lowering or diminishing the adverse effects of in practice therapeutic modalities. Therefore, engineering highly efficient, reliable, compatible, and recyclable biomaterials-based novel corrective cues with multipurpose applications is essential and a core demand to tackle many human health-related challenges, e.g., the current COVID-19 pandemic. Moreover, robust engineering design and properly exploited nano-bio materials deliver wide-ranging openings for experimentation in the field of interdisciplinary and multidisciplinary scientific research. In this context, herein, it is reviewed the applications and potential on tissue engineering and therapeutics of COVID-19 of several biomaterials. Following a brief introduction is a discussion of the drug delivery routes and mechanisms of biomaterials-based nano cues with suitable examples. The second half of the review focuses on the mainstream applications changing the dynamics of 21st century materials. In the end, current challenges and recommendations are given for a healthy and foreseeable future.

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Hydroxyapatite nanorods loaded with parathyroid hormone (PTH) synergistically enhance the net formative effect of PTH anabolic therapy

Cited by 20 publications

References 30 publications

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment

Modern World Applications for Nano-Bio Materials: Tissue Engineering and COVID-19

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