Hydroxyapatite Reinforced Polyvinyl Alcohol/Polyvinyl Pyrrolidone Based Hydrogel for Cartilage Replacement

Jalageri, Mallikarjun; Kumar, G. C. Mohan

doi:10.3390/gels8090555

Cited by 20 publications

(11 citation statements)

References 45 publications

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“…These blended hydrogels had antimicrobial activity against gram-negative and gram-positive bacteria and also stimulated bone mineral formation due to the release of calcium and phosphate ions from the nanorods. 78 5 | NEURONAL TISSUE ENGINEERING…”

Section: Other Methodsmentioning

confidence: 99%

“…Another study fabricated polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) hydrogels blended with hydroxyapatite nanorods. These blended hydrogels had antimicrobial activity against gram‐negative and gram‐positive bacteria and also stimulated bone mineral formation due to the release of calcium and phosphate ions from the nanorods 78 …”

Section: Cartilagementioning

confidence: 99%

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Cell‐instructive biomaterials in tissue engineering and regenerative medicine

Adhikari

Stager

Krebs

2023

J Biomedical Materials Res

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The field of biomaterials aims to improve regenerative outcomes or scientific understanding for a wide range of tissue types and ailments. Biomaterials can be fabricated from natural or synthetic sources and display a plethora of mechanical, electrical, and geometrical properties dependent on their desired application. To date, most biomaterial systems designed for eventual translation to the clinic rely on soluble signaling moieties, such as growth factors, to elicit a specific cellular response. However, these soluble factors are often limited by high cost, convoluted synthesis, low stability, and difficulty in regulation, making the translation of these biomaterials systems to clinical or commercial applications a long and arduous process. In response to this, significant effort has been dedicated to researching cell‐directive biomaterials which can signal for specific cell behavior in the absence of soluble factors. Cells of all tissue types have been shown to be innately in tune with their microenvironment, which is a biological phenomenon that can be exploited by researchers to design materials that direct cell behavior based on their intrinsic characteristics. This review will focus on recent developments in biomaterials that direct cell behavior using biomaterial properties such as charge, peptide presentation, and micro‐ or nano‐geometry. These next generation biomaterials could offer significant strides in the development of clinically relevant medical devices which improve our understanding of the cellular microenvironment and enhance patient care in a variety of ailments.

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Section: Other Methodsmentioning

confidence: 99%

Section: Cartilagementioning

confidence: 99%

Cell‐instructive biomaterials in tissue engineering and regenerative medicine

Adhikari

Stager

Krebs

2023

J Biomedical Materials Res

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“…Therefore, using tannic acid as a crosslinker in free-radical polymerization is difficult. Polyvinyl alcohol (PVA), thanks to its low cost, nontoxicity, and good biocompatibility, is a widely used polymeric material and has attracted extensive interest [ 27 , 28 , 29 , 30 , 31 ]. In the process of preparation of PVA, a repeated freeze–thaw process has been applied to physically crosslink via formation of a crystallization zone between PVA molecular chains [ 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

A Polyvinyl Alcohol–Tannic Acid Gel with Exceptional Mechanical Properties and Ultraviolet Resistance

Tian

Wang

et al. 2022

Gels

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Design and preparation of gels with excellent mechanical properties has garnered wide interest at present. In this paper, preparation of polyvinyl alcohol (PVA)–tannic acid (TA) gels with exceptional properties is documented. The crystallization zone and hydrogen bonding acted as physical crosslinkages fabricated by a combination of freeze–thaw treatment and a tannic acid compound. The effect of tannic acid on mechanical properties of prepared PVA–TA gels was investigated and analyzed. When the mass fraction of PVA was 20.0 wt% and soaking time was 12 h in tannic acid aqueous solution, tensile strength and the elongation at break of PVA–TA gel reached 5.97 MPa and 1450%, respectively. This PVA–TA gel was far superior to a pure 20.0 wt% PVA hydrogel treated only with the freeze–thaw process, as well as most previously reported PVA–TA gels. The toughness of a PVA–TA gel is about 14 times that of a pure PVA gel. In addition, transparent PVA–TA gels can effectively prevent ultraviolet-light-induced degradation. This study provides a novel strategy and reference for design and preparation of high-performance gels that are promising for practical application.

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“…This Special Issue focuses on the modification of hydrogels and their applications in biomedical engineering, aiming to provide a reference for scholars in related fields. Up until now, ten research articles and one review article have been collected, which mainly involve the application of hydrogels in biomedical fields such as phantoms [ 1 ], wound healing [ 2 , 3 ], skin [ 4 ], cartilage [ 5 , 6 ], muscle [ 7 ], and drug loading [ 8 , 9 , 10 ].…”

mentioning

confidence: 99%

“…The prepared composite hydrogel exhibits good flexibility, self-healing, and conductive performance, which shows great potential for applications in electronic skin. To obtain an ideal cartilage substitute, Jalageri et al [ 5 ] blended PVA and PVP with a one-dimensional hydroxyapatite nanorod (HNr) and synthesized a PVA/PVP/HNr composite hydrogel via the freeze–thaw method. The experimental results confirm that nanohydroxyapatite-reinforced PVA/PVP hydrogels are promising alternatives for next-generation cartilage substitutes.…”

mentioning

confidence: 99%