Hydroxychalcones as Potential Anti-Angiogenic Agent

Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study

“…Thienyl/furanyl-hydroxyphenylpropenones were synthesized by earlier reported methodology. [28][29][30] Base catalyzed reactions were performed without protection of hydroxyl group. Base catalyzed method employed 85% KOH (1.2 eq.)…”

Design and Synthesis of Fluorinated and/or Hydroxylated 2‐Arylidene‐1‐indanone Derivatives as an Inhibitor of LPS‐stimulated ROS Production in RAW 264.7 Macrophages with Structure–Activity Relationship Study

“…One of the reports showed the significant increase in the anti‐inflammatory activity of its chalcone derivatives by the insertion of halogen or hydroxyl in the nucleus of chalcones . Studies on hydroxychalcones have also shown to possess better anti‐angiogenic effects than that of non‐hydroxylated chalcones . Exifone (Figure (b)), an analogue of the polyhydroxy chalcones is well‐known as an anti‐Alzheimer’s disease drug .…”

Synthesis and Bioactivity of Reduced Chalcones Containing Sulfonamide Side Chains

“…( E )-3-(3-Hydroxyphenyl)-1-phenylprop-2-en-1-one ( 4 ) was obtained as yellow crystals (1.260 g, 23%): 1 H NMR δ (600 MHz, acetone- d 6 , Me 4 Si) 8.60 (s, 1 × O H ), 8.17–8.13 (2H, m, H-2″, H-6″), 7.81 (1H, d, J = 15.6 Hz, H-3), 7.73 (1H, d, J = 15.6 Hz, H-2), 7.66 (1H, tt, J = 6.9, 1.2 Hz, H-4″), 7.60–7.55 (2H, m, H-3″, H-5″), 7.33 (1H, dt, J = 7.6, 1.2 Hz, H-6′), 7.31 (1H, d, J = 7.6 Hz, H-5′), 7.29 (1H, t, J = 1.9 Hz, H-2′), 6.96 (1H, ddd, J = 7.6, 2.4, 1.3 Hz, H-4′); 13 C NMR δ (150 MHz, acetone- d 6 , Me 4 Si) 189.1 (C-1), 157.8 (C-3′), 144.1 (C-2), 138.2 (C-1″), 136.5 (C-1′), 132.8 (C-4″), 130.0 (C-5′), 128.7 (C-3″/ C-5″), 128.4 (C-2″/C-6″), 122.0 (C-3), 120.1 (C-6′), 117.6 (C-4′), 115.0 (C-2′).…”