Hydroxychavicol: A new phenolic antimutagen from betel leaf

Amonkar, A.J.; Nagabhushan, M.; D'Souza, A. V.; Bhide, S. V.

doi:10.1016/0278-6915(86)90065-7

Cited by 102 publications

(56 citation statements)

References 15 publications

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“…This can be at least partly explained by a proposed antimutagenic effect of the leaf. 22,23 More importantly, a significant increased risk and a positive trend were found in relation to daily quantity of betel use, suggesting the importance of the quantity of carcinogen exposure. In a study in Papua New Guinea by Thomas and MacLennan, 24 oral cancers were mostly found at the corner of the mouth and cheek that corresponds precisely with the application of the lime while chewing, causing the mean pH to rise to 10.…”

Section: Betel Quid Chewing Vs Pharynx and Larynxmentioning

confidence: 97%

Different impact from betel quid, alcohol and cigarette: Risk factors for pharyngeal and laryngeal cancer

Lee

Kuo

Tsai

et al. 2005

Intl Journal of Cancer

107

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The risks of betel quid chewing with or without tobacco, alcohol drinking and cigarette smoking have been well explored in the oral cavity but not in the pharynx and larynx. We conducted a case-control study to investigate the association of these three risk factors to cancers of the pharynx and larynx in Taiwan. A total cases of 148 pharyngeal cancer, 128 laryngeal cancer and 255 hospital controls, all men, were recruited. Betel quid chewing was a significant independent risk factor (adjusted odds ratio [aOR] 5 7.7; 95% confidence interval [CI] 5 4.1-15.0) similar to that of alcohol drinking (aOR 5 6.6; 95% CI 5 3.5-13.0) for pharyngeal cancer, but not for laryngeal cancer (aOR 5 1.3; 95% CI 5 0.7-2.5) on which cigarette smoking (aOR 5 7.1) exerts a stronger significant independent risk than alcohol drinking (aOR 5 3.8). For pharyngeal cancers, chewers who consumed >20 quid/day, chewed with inflorescence in the quid or swallowed the betel quid juice were at higher risks; significant dose-response effects were found in daily quantity of drinking and chewing, and cumulative quantity of drinking. Synergistic effects from the 3 risk factors existed both on the pharynx (aOR 5 96.9) and the larynx (aOR 5 40.3), and attributed for 93.1% and 92.9% respectively. Our study is the first evidence to show that betel quid chewing without tobacco has different impact on the pharynx (digestive tract) and the larynx (airway), and supports the concept that exposure quantity and direct mucosal contact with the betel quid juice may contribute to carcinogenesis. Our results show an important insight into the impact of betel quid chewing on other sites of the digestive tract other than the oral cavity. ' 2005 Wiley-Liss, Inc.Key words: risk factors; areca; laryngeal neoplasms; pharyngeal neoplasms; betel; alcohol; cigarette Cigarette smoking and alcohol drinking are risk factors for cancers of the oral cavity, pharynx and larynx.1-6 Betel quid chewing with or without tobacco, a widespread habit in south and east Asian countries, is an important risk factor having both independent and synergistic effects with cigarette smoking and alcohol drinking for oral cancer.7-13 The risk of betel quid chewing without tobacco on the pharynx and larynx in humans has not been explored and is unknown.Betel nut (areca nut) is consumed by an estimated 400-600 million people worldwide, mainly IndoAsian, Chinese and Taiwanese. It has a long history of use and is deeply ingrained in many sociocultural and religious activities. 7,14 Betel nut is the seed of the fruit of the oriental palm, Areca catechu. It is seldom chewed alone but is usually consumed in the form of betel quid, which is most often prepared by adding different ingredients to the areca nut, for example, the betel fruit (unripe fruit, inflorescence of Piper betle), betel leaf (leaf of Piper betle), slaked lime, catechu and tobacco, mainly according to the local tradition and for the purpose of flavor enhancing. 11,14 In general, although chewers from different countries prepare betel quid ...

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Section: Betel Quid Chewing Vs Pharynx and Larynxmentioning

confidence: 97%

Different impact from betel quid, alcohol and cigarette: Risk factors for pharyngeal and laryngeal cancer

Lee

Kuo

Tsai

et al. 2005

Intl Journal of Cancer

107

View full text Add to dashboard Cite

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“…9,10 According to few researchers betel leaf is a source of many effector molecules which possibly play an important role in the pathway of chemical carcinogenesis and which might also stimulate the factors responsible for regression of OSMF by delaying the onset in BQ chewers. 3,11,12 On cytological examination relatively large population of superficial cell layer in oral mucosa was noted in BQ chewers than in PMG chewers, which could be probably due to presence of increased proliferation potential of superficial cells than in PMG chewers. Histopathological studies of silver staining nuclear organizing region (AgNOR) of mucosal biopsy samples of OSMF, neoplastic and leukoplakia tissues have shown that these analyses are directly proportional to the proliferation potential of cell and are second highest in OSMF.…”

Section: Discussionmentioning

confidence: 96%

Evaluation between Betel Quid and Pan Masala/Gutkha Habitual Chewers with OSMF

Jayanthi¹,

Supadminidevi²,

Shah³

2012

World Journal of Dentistry

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“…As mentioned earlier, collagen synthesis is stimulated by superoxide radicals. In group V rats, the betel leaf suppresses the production of oxygen radicals due to its content of powerful antioxidants, namely, ,-carotene, ascorbic acid, a-tocopherol, and the phenol hydroxy chavicol [48].…”

Section: Discussionmentioning

confidence: 99%

Studies on the Nature and Significance of Collagen in Experimentally Induced Oral Submucous Fibrosis in Rats.

Anuradha

Hirano

Devi

1999

J. Clin. Biochem. Nutr.

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SummaryOral submucous fibrosis (OSMF), a disease condition essentially found in Indians and southeast Asians has drawn attention mostly on the grounds of epidemiological and clinical manifestations, whereas the etiology is still uncertain. Since all OSMF patients are habitual chewers, it was thought ideal to experimentally induce OSMF in rats using betelnut extracts thereby establishing the toxic nature of betelnut. OSMF has been defined as a collagen disorder and the total collagen and collagen fractions in the different groups were analyzed. There was an increase in total collagen content and an increase in soluble fraction was also observed representing newly synthesized collagen. The group treated with panmasala, a commercial preparation available which is a combination of betelnut, tobacco, lime and spices showed no changes due to its chemopreventive efficacy. The importance of the results expected is that the causation and cure of many diseases involving collagen now lack a scientific basis. The results it is hoped would provide a means for classification of diseases at structural and molecular level so as to highlight a causal nexus between clinical expression of the disease and altered structural and compositional changes in OSMF.

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Hydroxychavicol: A new phenolic antimutagen from betel leaf

Cited by 102 publications

References 15 publications

Different impact from betel quid, alcohol and cigarette: Risk factors for pharyngeal and laryngeal cancer

Different impact from betel quid, alcohol and cigarette: Risk factors for pharyngeal and laryngeal cancer

Evaluation between Betel Quid and Pan Masala/Gutkha Habitual Chewers with OSMF

Studies on the Nature and Significance of Collagen in Experimentally Induced Oral Submucous Fibrosis in Rats.

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