Hydroxychloroquine: do we all see eye to eye? A single-site analysis of hydroxychloroquine dosing compared with the 2016 Revision of the American Academy of Ophthalmology guidelines

Sandhu, Vaneet Kaur; Goel, Neha; Duro, Theodore

doi:10.1177/0961203319826682

Cited by 4 publications

(4 citation statements)

References 3 publications

(3 reference statements)

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“…Twenty-six per cent of the patients were on doses exceeding the AAO recommended maximum by more than 5%. This is similar to the rates found in recent US rheumatology centre audits 2–4…”

Section: Resultssupporting

confidence: 89%

Hydroxychloroquine usage in US patients, their experiences of tolerability and adherence, and implications for treatment: survey results from 3127 patients with SLE conducted by the Lupus Foundation of America

et al. 2019

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“…Twenty-six per cent of the patients were on doses exceeding the AAO recommended maximum by more than 5%. This is similar to the rates found in recent US rheumatology centre audits 2–4…”

Section: Resultssupporting

confidence: 89%

Hydroxychloroquine usage in US patients, their experiences of tolerability and adherence, and implications for treatment: survey results from 3127 patients with SLE conducted by the Lupus Foundation of America

et al. 2019

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“…9 Yet, some studies have reported a large number of patients whose therapy has exceeded this dose. A recent study by Sandhu et al 31 analyzed a group of 138 SLE patients taking HCQ and reported that 41% exceeded the recommended maximum dose. A similar study by Wallace et al 32 reported that, in 2696 SLE patients, 26% were on exceeding doses.…”

Section: Discussionmentioning

confidence: 99%

Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

Jauregui

Parmann

Nuzbrokh

et al. 2020

Trans. Vis. Sci. Tech.

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“…In addition, early/moderate cases oftentimes will remain stable after drug discontinuation, while severe cases may continue to advance for up to 20 years 85–88. Unfortunately, screening regimens and dosing practices remain insufficient and inconsistent despite published guidelines, emphasizing the importance of ophthalmologists and retina specialists in patient education 89–95…”

Section: Retinal/rpe Relatedmentioning

confidence: 99%

“…[85][86][87][88] Unfortunately, screening regimens and dosing practices remain insufficient and inconsistent despite published guidelines, emphasizing the importance of ophthalmologists and retina specialists in patient education. [89][90][91][92][93][94][95]…”

Section: Managementmentioning

confidence: 99%

The Impact of Systemic Medications on Retinal Function

Somisetty

Santina

Sarraf

et al. 2023

Asia-Pacific Journal of Ophthalmology

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This study will provide a thorough review of systemic (and select intravitreal) medications, along with illicit drugs that are capable of causing various patterns of retinal toxicity. The diagnosis is established by taking a thorough medication and drug history, and then by pattern recognition of the clinical retinal changes and multimodal imaging features. Examples of all of these types of toxicity will be thoroughly reviewed, including agents that cause retinal pigment epithelial disruption (hydroxychloroquine, thioridazine, pentosan polysulfate sodium, dideoxyinosine), retinal vascular occlusion (quinine, oral contraceptives), cystoid macular edema/retinal edema (nicotinic acid, sulfa-containing medications, taxels, glitazones), crystalline deposition (tamoxifen, canthaxanthin, methoxyflurane), uveitis, miscellaneous, and subjective visual symptoms (digoxin, sildenafil). The impact of newer chemotherapeutics and immunotherapeutics (tyrosine kinase inhibitor, mitogen-activated protein kinase kinase, checkpoint, anaplastic lymphoma kinase, extracellular signal-regulated kinase inhibitors, and others), will also be thoroughly reviewed. The mechanism of action will be explored in detail when known. When applicable, preventive measures will be discussed, and treatment will be reviewed. Illicit drugs (cannabinoids, cocaine, heroin, methamphetamine, alkyl nitrite), will also be reviewed in terms of the potential impact on retinal function.

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Hydroxychloroquine: do we all see eye to eye? A single-site analysis of hydroxychloroquine dosing compared with the 2016 Revision of the American Academy of Ophthalmology guidelines

Cited by 4 publications

References 3 publications

Hydroxychloroquine usage in US patients, their experiences of tolerability and adherence, and implications for treatment: survey results from 3127 patients with SLE conducted by the Lupus Foundation of America

Hydroxychloroquine usage in US patients, their experiences of tolerability and adherence, and implications for treatment: survey results from 3127 patients with SLE conducted by the Lupus Foundation of America

Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

The Impact of Systemic Medications on Retinal Function

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