2020
DOI: 10.3389/fphar.2020.597985
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Hydroxychloroquine in COVID-19 Patients: Pros and Cons

Abstract: The pandemic of COVID-19, caused by SARS-CoV-2, has recently overwhelmed medical centers and paralyzed economies. The unparalleled public distress caused by this pandemic mandated an urgent quest for an effective approach to manage or treat this disease. Due to their well-established anti-infectious and anti-inflammatory properties, quinine derivatives have been sought as potential therapies for COVID-19. Indeed, these molecules were originally employed in the treatment and prophylaxis of malaria, and later in… Show more

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Cited by 30 publications
(33 citation statements)
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“…During this time, thanks to lock-down measures, the contagion curve progressively decreased and enrolment was mainly carried out throughout the second Italian wave of COVID-19 pandemics (September and October 2020). This had major consequences on the best available therapy due to the controversies relatively to HCQ use [36] when steroid therapy was confirmed to be effective, according to this the attending physicians started steroids in case of clinical deterioration, more frequent in SOC arm [26] , [27] . These conditions had consequences on the full comparability of the two study arms and may have masked the positive effect of O 3 -AHT yielding partially discordant results with the other case-control studies.…”
Section: Discussionmentioning
confidence: 99%
“…During this time, thanks to lock-down measures, the contagion curve progressively decreased and enrolment was mainly carried out throughout the second Italian wave of COVID-19 pandemics (September and October 2020). This had major consequences on the best available therapy due to the controversies relatively to HCQ use [36] when steroid therapy was confirmed to be effective, according to this the attending physicians started steroids in case of clinical deterioration, more frequent in SOC arm [26] , [27] . These conditions had consequences on the full comparability of the two study arms and may have masked the positive effect of O 3 -AHT yielding partially discordant results with the other case-control studies.…”
Section: Discussionmentioning
confidence: 99%
“…By early May 2020, the virus had already reached over 200 countries worldwide afflicting at least 4 million victims. As of February 10, 2021, there have been more than 106 million confirmed cases of COVID-19 and more than 2 million deaths around the globe [3,4].…”
Section: Introductionmentioning
confidence: 99%
“…Summary of proposed COVID-19 therapies and their potential cardiovascular complications[8,57,[60][61][62][63][64][65][66].…”
mentioning
confidence: 99%