Hydroxycinnamic Acids in Crepidiastrum denticulatum Protect Oxidative Stress-Induced Retinal Damage

Abstract

We investigated the effects of an ethanol extract of C. denticulatum (EECD) in a mouse model of glaucoma established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death caused by ONC. Furthermore, EECD effectively protected against N-methyl-d-aspartate-induced damage to the rat retinas. In vitro, EECD attenuated transformed retinal ganglion cell (RGC-5) death and significantly blunted the up-regulation of apoptotic proteins and mRNA level induced by 1-buthionine-(S,R)-sulfoximine combined with glutamate, reduced reactive oxygen species production by radical species, and inhibited lipid peroxidation. The major EECD components were found to be chicoric acid and 3,5-dicaffeoylquinic acid (3,5-DCQA) that have shown beneficial effects on retinal degeneration both in vitro and in vivo studies. Thus, EECD could be used as a natural neuroprotective agent for glaucoma, and chicoric acid and 3,5-DCQA as mark compounds for the development of functional food.

Cyanidin‐3‐glucoside and its phenolic acid metabolites attenuate visible light‐induced retinal degeneration in vivo via activation of Nrf2/HO‐1 pathway and NF‐κB suppression

“…However, given the biological instability and extensive metabolism of ACNs , their degradation products, especially phenolic acids, are probably responsible for retina protective bioactivity. Phenolic acids have shown beneficial effects on retinal degeneration in vitro and in vivo . Chlorogenic acid is responsible for reduction of the apoptosis of retinal cells induced by hypoxia and NO .…”

“…Chlorogenic acid is responsible for reduction of the apoptosis of retinal cells induced by hypoxia and NO . Chicoric acid can ameliorate the oxidative stress‐induced degeneration of retinal ganglion cells through its antioxidative and antiapoptotic effects . Hydrocaffeic acid protects against ocular inflammation and cell oxidation damage induced by UV‐B in vivo .…”

Chemical characteristics of different parts of Coreopsis tinctoria in China using microwave‐assisted extraction and high‐performance liquid chromatography followed by chemometric analysis

“…Other major components in C. morifolium samples that could not be identified by the investigated compounds were tentatively categorized as CQAs derivatives according to the similar UV spectra with chlorogenic acid, with the absorption at 199, 300 (sh), 330 nm. It was reported that CQAs derivatives possessed antioxidant activities and other beneficial effects such as anti‐inflammatory and anticancer activities . It was observed that all flower samples possessed > 9.0 mg/g of CQAs derivatives (Table ).…”

The Protective Effect of Antioxidant Enriched Fractions from Colored Potatoes Against Hepatotoxic Oxidative Stress in Cultured Hepatocytes and Mice

“…; Ahn et al . ). The major hydroxycinnamate contained in the methanol extracts and antioxidant enriched fractions was 5‐caffeoylquinic acid (5‐CQA).…”