2019
DOI: 10.3390/antiox8030062
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Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells

Abstract: Carotid body (CB) chemoreceptor cells sense arterial blood PO2, generating a neurosecretory response proportional to the intensity of hypoxia. Hydrogen sulfide (H2S) is a physiological gaseous messenger that is proposed to act as an oxygen sensor in CBs, although this concept remains controversial. In the present study we have used the H2S scavenger and vitamin B12 analog hydroxycobalamin (Cbl) as a new tool to investigate the involvement of endogenous H2S in CB oxygen sensing. We observed that the slow-releas… Show more

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Cited by 5 publications
(2 citation statements)
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“…The pharmacological approach used makes it difficult to separate out potential redundant control mechanisms, with those that are acting in parallel. If redundant mechanisms were at play in the current investigation, then they must have been induced very rapidly as pharmacological interventions were only applied for a maximum of 1 h. The lack of complete elimination of the response to hypoxia in the presence of DMM, MitoT, and SKQ1 also does not rule out the involvement of other mediators independent of mitochondrial function including H 2 S [ 45 , 46 ] and ROS derived from other sources such as NADPH oxidase [ 47 , 48 ]. Whilst mitoROS may be elevated in hypoxia, in other compartments, they may be decreased and the specific interactions between ROS and ion channels require further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…The pharmacological approach used makes it difficult to separate out potential redundant control mechanisms, with those that are acting in parallel. If redundant mechanisms were at play in the current investigation, then they must have been induced very rapidly as pharmacological interventions were only applied for a maximum of 1 h. The lack of complete elimination of the response to hypoxia in the presence of DMM, MitoT, and SKQ1 also does not rule out the involvement of other mediators independent of mitochondrial function including H 2 S [ 45 , 46 ] and ROS derived from other sources such as NADPH oxidase [ 47 , 48 ]. Whilst mitoROS may be elevated in hypoxia, in other compartments, they may be decreased and the specific interactions between ROS and ion channels require further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…In a mouse paclitaxel-induced neuropathic pain model, GYY4137 treatment demonstrated anti-hyperalgesic activity and co-treatment with a KATP channel inhibitor blocked this anti-hyperalgesic activity [ 103 ]. In cultured carotid body, a cluster of chemoreceptor cells from bilateral sensory organs in the peripheral nervous system, NaHS treatment triggered transient calcium influx, which depended on the calcium in the culture media, suggesting that H 2 S regulates calcium channels in carotid bodies [ 104 ].…”
Section: H 2 S Regulates Different Cellular Proces...mentioning
confidence: 99%