Hydroxyethyl Starch: The Effect of Molecular Weight and Degree of Substitution on Intravascular Retention In Vivo

Hitosugi, Takashi; Saito, Tomoyo; Suzuki, So No; Kubota, Ieko; Shoda, Emi; Shimizu, Toru; Oi, Yoshiyuki

doi:10.1213/01.ane.0000275198.84094.ad

Cited by 10 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, destruction of the endothelial glycocalyx leads to extravasation of either HES or albumin, opposing the previous findings . Furthermore, significant extravasation was observed within seconds under intravital microscopy in a mild hemorrhage rodent model . As most of these studies were conducted under experimental conditions or on isolated tissue, the effects of HES on vascular permeability in patients affected by spontaneous disease remains unclear.…”

Section: Hes Plugs the Leaks In The Vascular Endotheliummentioning

confidence: 74%

Controversies in the use of hydroxyethyl starch solutions in small animal emergency and critical care

Adamik

Yozova

Stokar-Regenscheit

2015

J Vet Emergen Crit Care

View full text Add to dashboard Cite

Currently, there are no consensus recommendations regarding the use of HES in veterinary medicine. Veterinarians and institutions affected by the HES restrictions have had to critically reassess the risks and benefits related to HES usage based on the available information and sometimes adapt their procedures and policies based on their reassessment. Meanwhile, large, prospective, randomized veterinary studies evaluating HES use are needed to achieve relevant levels of evidence to enable formulation of specific veterinary guidelines.

show abstract

Section: Hes Plugs the Leaks In The Vascular Endotheliummentioning

confidence: 74%

Controversies in the use of hydroxyethyl starch solutions in small animal emergency and critical care

Adamik

Yozova

Stokar-Regenscheit

2015

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

“…Hence, in spite of the considerable number and diversity of carbohydrate drugs recorded in the pharmacopoeias, more comprehensive and normalized (18). Besides, swine duodenum mucopolysaccharide extracted from the duodenum of healthy swines with a glucosamine content of more than 20.0%, is produced in China as an anti-coronary atherosclerosis pharmaceutical.…”

Section: Carbohydrate Drugs Marketedmentioning

confidence: 99%

Carbohydrate drugs: current status and development prospect

Zhang

Wang

2015

DD&T

View full text Add to dashboard Cite

“…However, diffusion of different molecular weight HES into surrounding tissues has been confirmed in animal models [44]. However, diffusion of different molecular weight HES into surrounding tissues has been confirmed in animal models [44].…”

Section: -Crystalloids Vs Colloidsmentioning

confidence: 99%

Statin Therapy

Koch¹

2012

CPD

View full text Add to dashboard Cite

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are primarily used to treat dyslipidemia. Yet, these medications have a number of additional important pleiotropic properties that confer patient benefit in terms of reduced cardiovascular morbidity. Investigators have reported that statins may be underutilized in patients undergoing cardiac surgical procedures. Periprocedural benefits have been reported both in the short-term as well as with long - term post discharge follow-up period for both surgical and percutaneous coronary interventions. Mechanisms for statin's demonstrated benefit include improved endothelial function, antiinflammatory properties and stabilization of atherosclerotic plaque. While there are well-recognized side effects to statin therapy, its beneficial impact on patient cardiovascular outcomes is clear. Further research is necessary to determine specific patients who would best benefit from preoperative statin therapy, the dose and duration of therapy prior to surgical interventions and the influence of administration following surgery.

show abstract

Hydroxyethyl Starch: The Effect of Molecular Weight and Degree of Substitution on Intravascular Retention In Vivo

Abstract: HES-B and HES-C are equally retained in the blood vessels. Middle-sized HES-B with low DS and middle substitution pattern stayed in the blood vessels as long as the large-sized HES. HES solutions of varying characters should be examined to optimize HES infusion.

Cited by 10 publications

References 19 publications

Controversies in the use of hydroxyethyl starch solutions in small animal emergency and critical care

Controversies in the use of hydroxyethyl starch solutions in small animal emergency and critical care

Carbohydrate drugs: current status and development prospect

Statin Therapy

Contact Info

Product

Resources

About