Hydroxyl end-functionalized poly(2-isopropyl oxazoline)s used as nano-sized colloidal templates for preparation of hollow polymeric nanocapsules

Toncheva, N.; Tsvetanov, Christo B.; Rangelov, Stanislav; Trzebicka, Barbara; Dworak, Andrzej

doi:10.1016/j.polymer.2013.07.042

Cited by 22 publications

(24 citation statements)

References 24 publications

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“…In addition to hard templates, soft templates have also been used for the preparation of polymer capsules via various polymerization methods. Recent studies have demonstrated that seeded radical copolymerization can be used to prepare polymer capsules using thermosensitive spheres (PNIPAM) as templates, which can be removed in water via dialysis below the lower critical solution temperature [205][206][207][208]. Copolymerization in liposomal bilayers has resulted in polymer nanocapsules with uniform nanopores, which have been used for the selective encapsulation and release of cargos [209][210][211].…”

Section: Soft Template Polymerization Methodsmentioning

confidence: 99%

Emerging methods for the fabrication of polymer capsules

Cui

Koeverden

Müllner

et al. 2014

Advances in Colloid and Interface Science

176

178

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Hollow polymer capsules are attracting increasing research interest due to their potential application as drug delivery vectors, sensors, biomimetic nano- or multi-compartment reactors and catalysts. Thus, significant effort has been directed toward tuning their size, composition, morphology, and functionality to further their application. In this review, we provide an overview of emerging techniques for the fabrication of polymer capsules, encompassing: self-assembly, layer-by-layer assembly, single-step polymer adsorption, bio-inspired assembly, surface polymerization, and ultrasound assembly. These techniques can be applied to prepare polymer capsules with diverse functionality and physicochemical properties, which may fulfill specific requirements in various areas. In addition, we critically evaluate the challenges associated with the application of polymer capsules in drug delivery systems.

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Section: Soft Template Polymerization Methodsmentioning

confidence: 99%

Emerging methods for the fabrication of polymer capsules

Cui

Koeverden

Müllner

et al. 2014

Advances in Colloid and Interface Science

176

178

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“…The formation of defined mesoglobules upon increasing the temperature of an aqueous solution of PiPrOx was utilized by Rangelov et al as template for the construction of hollow capsules. 95 The collapsed mesoglobules of PiPrOx were utilized as seeds for the radical polymerization of NIPAM and a crosslinker above the T cp of both PiPrOx and PNIPAM. Subsequent lowering of the temperature below the T cp of both polymers allowed extraction of the non-crosslinked PiPrOx core by diffusion through the cross-linked PNIPAM layer leading to hollow thermoresponsive PNIPAM capsules.…”

Section: Thermoresponsive Polyamides or Polymeric Amidesmentioning

confidence: 99%

Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides

2017

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“…Temperature‐induced self‐assembly and crystallization of PIPOX in aqueous and organic solutions have been reported . Besides, temperature‐induced formation of PIPOX mesoglobules above the critical temperature and release of biomolecules from mesoglobule templates have been demostrated …”

Section: Introductionmentioning

confidence: 97%

An experimental and computational approach to pH‐dependent self‐aggregation of poly(2‐isopropyl‐2‐oxazoline)

Cagli

Yıldırım

Yang

et al. 2018

J Polym Sci B Polym Phys

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Besides temperature, self-aggregation of poly(2-isopropyl-2-oxazoline) (PIPOX) can also be triggered via pH in aqueous solution (25 C, pH > 5). Lowest energy structures and interaction energies of PIPOX with H 3 O + , OH − , and H 2 O were calculated by DFT methods showed that, in addition to their ability to protonate PIPOX, H 3 O + ions had strong interaction with both water and PIPOX in acidic conditions. H 3 O + ions acted as compatibilizer between PIPOX and water and increased the solubility of PIPOX. OH − ions were found to have stronger interaction with water compared to PIPOX resulting in desorption of water molecules from PIPOX phase and decreased solubility, leading to enhanced hydrophobic interactions among isopropyl groups of PIPOX and formation of aggregates at high pH. Results concerning the effect of end-groups on aggregate size were in good agreement with statistical mechanics calculations. Moreover, the effect of polymer concentration on the aggregate size was examined. to understand the mechanism of pH-induced self-assembly. The chemical nature of the end-groups was found to be critical on the self-association of PIPOX, thus the Additional Supporting Information may be found in the online version of this article. 1 μm 10 μm 5 μm FIGURE 8 SEM images of PIPOX at pH 2.5 and pH 7.5 at 0.2 mg/mL, 0.6 mg/mL, and 1 mg/mL concentration.

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Hydroxyl end-functionalized poly(2-isopropyl oxazoline)s used as nano-sized colloidal templates for preparation of hollow polymeric nanocapsules

Cited by 22 publications

References 24 publications

Emerging methods for the fabrication of polymer capsules

Emerging methods for the fabrication of polymer capsules

Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides

An experimental and computational approach to pH‐dependent self‐aggregation of poly(2‐isopropyl‐2‐oxazoline)

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