Hydroxyl–PEG–Phosphonic Acid-Stabilized Superparamagnetic Manganese Oxide-Doped Iron Oxide Nanoparticles with Synergistic Effects for Dual-Mode MR Imaging

Lu, Chichong; Dong, Pingli; Pi, Lei; Wang, Zhijie; Yuan, Hang; Liang, Huaping; Ma, Dongge; Chai, Kyu Yun

doi:10.1021/acs.langmuir.9b00736

Cited by 38 publications

(30 citation statements)

References 55 publications

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“…A promising T 1 -T 2 dual-mode contrast agent for MRI was developed in a recent study, consisting of superparamagnetic manganese oxide-doped iron oxide (Fe 3 O 4 /MnO) nanoparticles of approximately 20 nm stabilized with hydroxyl− PEG-phosphonic acid [ 199 ]. The T 1 -T 2 weighted images—obtained using a 0.5 T MRI scanner—validated the dual-mode contrast ability on phantoms.…”

Section: Surface Shell Engineering Of Magnetic Materials For Imaging Purposesmentioning

confidence: 99%

“…Therefore, we described only silica and PEGylation strategies in this section, since our group has contributed to this field. Thermal decomposition PEG MRI [190][191][192] MRI/SPECT ( 99m Tc) [193] MRI/SPECT ( 125 I) [106,194] MRI/PET ( 68 Ga) [195] MRI/PET ( 64 Cu) [196] MRI/PET ( 71 As) [197] SPECT ( 99m Tc) [174] [198] Hydroxyl−PEG−Phosphonic Acid [199] DSPE-mPEG 2000 /DSPE-mPEG 2000 amine MRI/PET ( 68 Ga) [200] Silica MRI [201,202] MRI/US [203] Mesoporous Silica MRI [202,204] MRI/Fluorescence Imaging [190] Silica MRI/Optical (FITC) [205] Hydrothermal…”

Section: Synthetic Biocompatible Polymersmentioning

confidence: 99%

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Imaging Constructs: The Rise of Iron Oxide Nanoparticles

et al. 2021

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Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic magnetic properties, low toxicity, large magnetic moments, superparamagnetic behaviour and large surface area—the latter being a particular advantage in its conjunction with specific moieties, dye molecules, and imaging probes. Tracers-based nanoparticles are promising candidates, since they combine synergistic advantages for non-invasive, highly sensitive, high-resolution, and quantitative imaging on different modalities. This study represents an overview of current advancements in magnetic materials with clinical potential that will hopefully provide an effective system for diagnosis in the near future. Further exploration is still needed to reveal their potential as promising candidates from simple functionalization of metal oxide nanomaterials up to medical imaging.

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Section: Surface Shell Engineering Of Magnetic Materials For Imaging Purposesmentioning

confidence: 99%

Section: Synthetic Biocompatible Polymersmentioning

confidence: 99%

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

et al. 2021

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“…Based on this theory, Lu et al [115] embedded Mn 2+ into Fe 3 O 4 NPs with hydroxyl-PEG-phosphonic acid through a one-pot reaction (Fe 3 O 4 /MnO, with a size of 20 nm) to improve synergistically imaging performance with safe and accuracy because Mn 2+ was T 1 -weighted CA [116]. The stability test indicated that the nanoparticles retained a single scattering peak even though their size increased to 35 nm from 21 nm after 21 days in water.…”

Section: Application Of Fe 3 O 4 Doping Other Metals In the Inner Corementioning

confidence: 99%

Progress in magnetic Fe₃O₄nanomaterials in magnetic resonance imaging

Yang

Hui

et al. 2020

Nanotechnology Reviews

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At present, high-sensitivity, high-penetration-depth, and accurate tissue resolution clinical imaging effect are required, while computer transverse scanning, microwave imaging, and fluorescence imaging (FL) cannot meet the requirements of clinical imaging, but the magnetic resonance imaging (MRI) can meet the requirements of clinical dissecting details. The effect of MRI imaging is closely related to the contrast agent (CA). As an important type of CA, Fe3O4 and its analogues have been widely concerned because of their low toxicity and relatively low price. In this review, we summarize the development and improvement of CAs based on Fe3O4 and its analogues from T 2 imaging mode and development limitation in the initial single modulus imaging mode, to T 1 imaging mode overcoming the limitations of T 2 imaging and the limitations of its own in application, to the later development of dual modulus imaging form, and to the current multi-modulus imaging form. Simultaneously, we demonstrate the research progress, preparation methods, and future trends based on Fe3O4 and its analogues CAs for MRI, the current application status is preliminarily summarized, and the future development trend is prospected.

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“…[40][41][42] FTIR 43,44 In addition stretching vibrations near 1060 cm −1 which could be assigned to P−O−C and at 1241 cm −1 referring to PvO were observed showing clearly the successful grafting of PEG-PA on the surface of magnetic NPs. 45 A TEM image of the magnetic NPs used in this study is presented in Fig. 2A.…”

Section: Nanoparticle Characterizationmentioning

confidence: 99%