Hydroxyphenylalkanones from Amomum melegueta

Tackie, Albert N.; Dwuma-Badu, D.; Ayim, J.S.K.; Dabra, T T; Knapp, Joseph E.; Slatkin, David J.; Schiff, Paul L.

doi:10.1016/0031-9422(75)83070-6

Cited by 34 publications

(13 citation statements)

References 3 publications

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“…Furthermore, it inhibited castor oil-induced intestinal transit in a dose-related manner. Previous studies carried out by Tackie et al (1975) revealed the presence of 6-paradol, 7-paradol, 6-shogoal, gingerol, and zingerone as the active chemical constituents in the seed of this plant. These chemical substances have been shown to be responsible for the biological activities demonstrated by A. melegueta (Rafatullah et al, 1995;Galal, 1996;Umukoro & Ashorobi, 2001).…”

Section: Discussionmentioning

confidence: 96%

Effect ofAframomum melegueta. Seed Extract on Castor Oil–Induced Diarrhea

Umukoro

Ashorobi

2005

Pharmaceutical Biology

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The effect of the aqueous (aq) seed extract of Aframomum melegueta. K. Schum. (Zingiberaceae) on castor oil-induced diarrhea, intestinal fluid secretion, and gastrointestinal transit was investigated in the study. Castor oil (10 ml/kg, p.o.) induced copious diarrhea in all rats 3 h after treatment. Furthermore, it produced a significant increase in the volume of intestinal fluid secretion in rats and also enhanced intestinal transit in mice. The aq seed extract of A. melegueta. (100-500 mg/kg, p.o.) offered significant protection against diarrhea induced by the oil. At a dose range of 250-500 mg/kg, the extract reduced significantly the volume of fluid secretion in castor oil-treated rats. At these doses, it also demonstrated a significant antitransit activity in a dose-related manner. Acetylsalicylic acid (100 mg/kg, p.o.) delayed diarrhea and reduced the number of animals with diarrheal droppings to 20%. At the same dose level, acetylsalicylic acid reduced significantly the volume of intestinal fluid secretion but lacked antitransit property in castor oil-treated animals. N.-Nitro-L-arginine methyl ester (L-NAME) (2.5-10 mg/kg, i.p.) dose-dependently reduced the number of animals with diarrhea. At 50 mg/kg i.p., it offered 100% protection against diarrhea induced by the oil. Furthermore, L-NAME (10 mg/kg, i.p.) significantly inhibited both the intestinal fluid secretion and gastrointestinal transit induced by castor oil. However, L-NAME (10 mg/kg, i.p.) did not significantly modify the antidiarrheal effect of A. melegueta.. L-Arginine, a substrate of nitric oxide synthase or isosorbide dinitrate, a nitric oxide donor, did not alter the effect of A. melegueta. on diarrhea. Ascorbic acid (100 mg/kg, p.o.) and α.-tocopherol (20 mg/kg, p.o.) reduced the number of animals with diarrhea to 80% and 70%, respectively. However, they both lacked significant activities on intestinal fluid secretion and gastrointestinal transit induced by castor oil. The combination of ascorbic acid (100 mg/kg, p.o.) or α.-tocopherol (20 mg/kg, p.o.) with A. melegueta. (500 mg/kg) offered higher protection against diarrhea than the extract alone. Considering these results together, it may be inferred that Aframomum melegueta. seed extract may be a useful antidiarrheal agent.

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Section: Discussionmentioning

confidence: 96%

Effect ofAframomum melegueta. Seed Extract on Castor Oil–Induced Diarrhea

Umukoro

Ashorobi

2005

Pharmaceutical Biology

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“…Capsaicin and capsiate bear structural similarities to the non-volatile vanilloids found in GP [32] [33] [34]. It has also been reported that 6-paradol and 6-shogaol in GP extract were found to activate TRPV1 through non-covalent bonding [35].…”

Section: Discussionmentioning

confidence: 99%

Effect of Grains of Paradise (GP) Extract Intake on Obesity and Sympathetic Nerve Activity

Hattori¹,

Yamauchi²,

Onwona-Agyeman³

et al. 2017

AJPS

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The methanol extract of grains of paradise (GP), the seed of Aframomum melegueta, which is distributed throughout West Africa, was administered during an animal breeding test. The extract suppressed body weight gain and decreased the weight of adipose tissues in breeding mice, with a greater effect on mice fed a high-fat diet (HFD) than on those fed a normal diet (ND). Other significant effects of GP intake included increased serum triglyceride (TG) concentration and reduced hepatic total cholesterol (TC) and TG concentrations. GP intake markedly prevented fat accumulation and improved hepatic lipid metabolism in HFD-fed mice. In addition, GP extract at a dosage of 5 mg/kg body weight decreased sympathetic nerve activity (SNA) in brown adipose tissue (BAT), while capsaicin, a major component of chili pepper, activated BAT SNA. This suggested that GP exerts a potential anti-obesity effect by a different mechanism from that of capsaicin.

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“…The seed extract of this plant is also used as a remedy for leprosy, measles, and in the control of postpartum haemorrhage (Iwu et al, 1999). Phytochemical studies have revealed the isolation and characterization of pharmacologically active compounds in the seed of Aframomum melegueta (Connell, 1970;Tackie et al, 1975;Galal, 1996). These active compounds (hydroxyphenylalkanones) consist mainly of paradol, shogoal, zingerone and gingerol (Galal, 1996).…”

Section: Introductionmentioning

confidence: 99%