Hydroxyphenylquinazolinone-based turn-on fluorescent probe for β-galactosidase activity detection and application in living cells

Yang, Wenge; Zhao, Xinxin; Jian, Zhang; Zhou, Yi; Fan, Shimin; Sheng, Huace; Cao, Yang; Hu, Yonghong

doi:10.1016/j.dyepig.2018.04.003

Cited by 44 publications

(17 citation statements)

References 40 publications

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“…These are features that make this probe particularly suitable for intracellular imaging applications. 220 Liu and co-workers developed a salicylaldehyde-derived azine fluorescent probe 89 that was designed to display both an AIE and an ESIPT response to b-Gal (Scheme 78). Upon addition of b-Gal, the galactose recognition units were cleaved.…”

Section: àmentioning

confidence: 99%

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

et al. 2018

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Section: àmentioning

confidence: 99%

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

et al. 2018

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“…Recently, fluorescence properties of heterocyclic compounds have also received much more attention. For example, dibenzo[a,c] [1,2,5] tiadiazolo [3,4-i]phenazine [6], fluorimetric [7], hydroxyphenylquinazolinone [8], 3-hydroxyflavone derivative [9], carbazole schiff base [10], have been applied to fluorescence chemosensor or probe. Alkynylgold(III) complexes [11], pyrene-pyrazoline [12], piro-annulated benzimidazole host [13] have been used as organic light-emitting devices.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Fluorescence Properties of Two New Heterocyclic Compounds Containing 1,5-Dioxaspiro Group

Zeng

Jiang

et al. 2018

Crystals

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A precursor, C 21 H 29 NO 8 (A1) was prepared by reactions of 1,1-dimethoxy-N,Ndimethylmethanamine and 1,5-dioxaspiro[5.5]undecane-2,4-dione. The new N-containing heterocyclic compound, C 19 H 19 NO 4 (B1) was obtained by adding A1 into ethanol solution of o-toluidine. The crystal structure determination of two compounds were both found to belong to the triclinic P-1 space group. The precursor includes one (C 2 H 8 N) + cation and one (C 19 H 21 O 8 ) − anion, which constituted a chained structure by N-H···O intra-and intermolecular interactions. The title compound (B1) formed a 3D-network structure by weak C-H···O intermolecular interactions and π···π stacking interactions. The fluorescent behaviors of A1 and B1 in ethanol solution were discussed. The result shows that they exhibit blue and purplish blue emission, respectively.

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“…[ 197,198 ] Deficiency of β ‐gal can lead to Morquio B syndrome or β‐ galactosialidosis. [ 199,200 ] Its overexpression is associated with malignant tumors and cell senescence. [ 201–204 ] Therefore, sensitive detection and imaging of β ‐gal are of great importance.…”

Section: Aiegens For Recognition Of Enzymesmentioning

confidence: 99%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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Activity‐based approaches for designing AIEgens possess prominent advantages including high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention in recent years. Excellent activatable AIE probes have been reported for detecting toxic substances, imaging intracellular active molecules/biomolecules, as well as monitoring the activity of overexpressed enzymes in cancers. Moreover, the majority of activatable theranostic AIEgens can be specifically triggered in cancer cells and can kill these cells under light irradiation, while they have no distinct effect on normal cells, demonstrating satisfactory therapeutic selectivity that is superior to that of traditional chemotherapy. Thus, in this review, we systematically summarized the development of activatable AIE bioprobes in recent years from molecular design principles to biological applications. The challenges of activatable AIE probes and the corresponding solutions are described. We hope that the information provided in this review will facilitate the design of more activatable AIE probes to promote practical application of corresponding AIEgens.

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Hydroxyphenylquinazolinone-based turn-on fluorescent probe for β-galactosidase activity detection and application in living cells

Cited by 44 publications

References 40 publications

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

Synthesis, Characterization, and Fluorescence Properties of Two New Heterocyclic Compounds Containing 1,5-Dioxaspiro Group

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

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