Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection

Jang, In Seung; Park, Sun Joo

doi:10.3892/mmr.2016.5949

Cited by 7 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, collagen peptides are key ingredients in nutricosmetic products and supplementary health food because they can increase skin hydration and improve facial skin conditions (Inoue et al 2016). In pharmaceutical applications, a hydroxyprolinecontaining marine collagen peptide from Alaska pollack inhibits human immunodeficiency virus (HIV-1) infection (Jang and Park 2016).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Chen

Liang

et al. 2018

J Food Sci Technol

View full text Add to dashboard Cite

Milkfish (), which is resistant to water quality changes is the fourth largest aquaculture commodity. Abandoned wastes of fish scale and bones aggravate environmental pollution. In this study, the effect of collagen peptides isolated from milkfish scales (MSCP) by pepsin-soluble collagen method on cell viability was investigated. The antioxidant, anti-inflammatory, and DNA-protective activities of MSCP were also evaluated. Results revealed that more than 95% of viable cells were retained in human keratinocytes after addition of 100 mg/mL MSCP. Measurement of DPPH· and ABTS· + radical scavenging activities and cellular reactive oxygen species revealed the high antioxidant activities of MSCP. MSCP demonstrated anti-inflammatory activities by reducing lipoxygenase activity and nitric oxide (NO·) radicals. Moreover, DNA electrophoresis assay indicated that MSCP treatment can directly protect against cyclobutane di-pyrimidine production and DNA single-strand breaks, which are harmful effects of UV radiation and HO. Given its antioxidant, anti-inflammatory, and DNA-protective activities, MSCP has potential applications in cosmeceuticals and supplementary health food.

show abstract

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Chen

Liang

et al. 2018

J Food Sci Technol

View full text Add to dashboard Cite

show abstract

“…These are small peptides rich in hydroxyproline residues that exhibit anti‐HIV‐1 activity. Jang et al . reported the anti‐HIV‐1 activity of their novel antiretroviral peptide with unique underlying mechanisms of action.…”

Section: Collagen Peptidesmentioning

confidence: 99%

Collagen from Marine Biological Sources and Medical Applications

Felician

Xia

et al. 2018

Chemistry & Biodiversity

219

140

View full text Add to dashboard Cite

Collagen is the most studied protein with a wide range of applications including pharmaceutical, biomedical, cosmetics, leather, and film industries due to its special characteristics that are high biocompatibility, good bioactivity, and weak antigenicity. Although collagen sources are abundant, the outbreak of varied diseases among land animals posed threat to its utilization in our daily life. Thus, a probe for an alternative source began, which in turn revealed the immense untapped marine sources, such as fish, jellyfish, and some marine Mammals. The present article deals with a brief description of collagen, its characteristics, marine sources, extraction, collagen peptides and their biological activities, potential use and application in various field.

show abstract

“…Marine sponges are not the sole source of bioactive proteins. For example, Jang et al reported about a new small hydroxyproline-rich peptide from Alaska Pollack collagen (APHCP, 21 , Figure 8) that exhibits a unique antiviral activity [94]. This peptide is a Gly-Pro-Hyp-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly peptide, and the authors showed that the most important part of a peptide for anti-HIV activity is the hydroxyl group at hydroxyproline, whereas a peptide with only prolines does not exhibit antiviral activity.…”

Section: Marine Compounds In the Treatment Of Hiv/aidsmentioning

confidence: 99%

Novel Antiretroviral Structures from Marine Organisms

et al. 2019

View full text Add to dashboard Cite

In spite of significant advancements and success in antiretroviral therapies directed against HIV infection, there is no cure for HIV, which scan persist in a human body in its latent form and become reactivated under favorable conditions. Therefore, novel antiretroviral drugs with different modes of actions are still a major focus for researchers. In particular, novel lead structures are being sought from natural sources. So far, a number of compounds from marine organisms have been identified as promising therapeutics for HIV infection. Therefore, in this paper, we provide an overview of marine natural products that were first identified in the period between 2013 and 2018 that could be potentially used, or further optimized, as novel antiretroviral agents. This pipeline includes the systematization of antiretroviral activities for several categories of marine structures including chitosan and its derivatives, sulfated polysaccharides, lectins, bromotyrosine derivatives, peptides, alkaloids, diterpenes, phlorotannins, and xanthones as well as adjuvants to the HAART therapy such as fish oil. We critically discuss the structures and activities of the most promising new marine anti-HIV compounds.

show abstract

Hydroxyproline-containing collagen peptide derived from the skin of the Alaska pollack inhibits HIV-1 infection

Cited by 7 publications

References 22 publications

Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales

Collagen from Marine Biological Sources and Medical Applications

Novel Antiretroviral Structures from Marine Organisms

Contact Info

Product

Resources

About