Hydroxypropyl methylcellulose phthalate beads containing a model non-steroid anti-inflammatory drug

Cerdeira, Ana M.; Goucha, P.; Almeida, António J.

doi:10.1016/s0378-5173(97)00432-8

Cited by 12 publications

(12 citation statements)

References 4 publications

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“…In a previous work (Cerdeira et al 1998), the application of the method described by Zaniboni et al (1995) to another NSAID molecule (etodolac) resulted in spherical shaped beads with a smooth surface. The authors concluded that this was probably a good method for the encapsulation of NSAIDs, since these molecules generally have similar physicochemical characteristics, e.g.…”

Section: Morphologymentioning

confidence: 95%

“…Since previous studies with beads containing etodolac (Cerdeira et al 1998) showed no shape distortion upon drying, it was hypothesized that the diå erences in crystal habit and/or size between the two model drugs studied could be responsible for the distorted shape of nimesulide beads. In those studies, the etodolac particle size was 6:4 § 0:4 mm, whereas the nimesulide obtained as a raw material has a median particle size of 40:0 § 2:1 mm (® gure 3(a)).…”

Section: Morphologymentioning

confidence: 99%

“…cellulose derivatives have been gelled by passing the droplets into an acidic bath (Habib andMesue 1995, Zaniboni et al 1995), or pectates and alginates into a calcium chloride bath (Kwok et al 1991). Production of enteric beads, based on droplet extrusion/ precipitation of an alkaline solution or suspension of hydroxypropyl methylcellulose phthalate (HP 50 ) in acidic media, has been applied to drugs with diå erent solubility values, showing that this is a more suitable technique for water insoluble drugs (Zaniboni et al 1995, Cerdeira et al 1998. It is well known that such formulation procedures are highly dependent on the physicochemical properties of drugs.…”

Section: Introductionmentioning

confidence: 99%

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Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method

Cerdeira

Gouveia

Goucha³

et al. 2000

Journal of Microencapsulation

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The influence of drug particle size on the production of enteric beads by a polymer precipitation technique was investigated. Drug particle dimensions are known to play an important role in most microencapsulation techniques. Bead morphology was greatly influenced by drug particle size, and spherical shaped beads could only be obtained after size reduction of nimesulide crystals. This is confirmed by the angle of repose measurements, which show a significant decrease in theta values when beads are formulated with smaller drug particles. Furthermore, results show that drug encapsulation efficiency and in vitro drug release rates are also greatly dependent on both drug particle size and drug/polymer ratio in the initial suspension. Preparations containing 10.2 microm drug particles show a two-fold increase in the release rates when compared to those prepared with 40 microm particles.

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Section: Morphologymentioning

confidence: 95%

Section: Morphologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method

Cerdeira

Gouveia

Goucha³

et al. 2000

Journal of Microencapsulation

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show abstract

“…As the solubility of HPMC is very low at 30C and is negligible when the temperature is more than 35-40C (Kolanowski et al 2004), HPMC can be easily dissolve in cold water. In the tablet coating, HPMC provides a physical barrier by generating a stable wall to the gastric mucosa against irritation (Sarkar and Walker 1995;Cerdeira et al 1998). Moreover, HPMC shows the property of thermoreversible gelation in aqueous solution, which means that when it is heated, it will form gel, and when it is cooled down, it will dissolve again (Gonjari et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Fish Oil Using Hydroxypropyl Methylcellulose As a Carrier Material by Spray Drying

Karim

Sarker

Ghafoor

et al. 2015

Journal of Food Processing and Preservation

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Spray drying is an important method in the food industry for the production of encapsulated oil to improve the handling and flow properties of the powder. In this study, the effect of mixture of polymers on the encapsulation of fish oil by spray drying was investigated. Fish oil powder were produced using different ratios of mixtures of hydroxypropyl methylcellulose (HPMC) 15 cps and HPMC 5 cps. Scanning electron microscopy and the amount of extracted oil from the surface revealed that the formulation containing high concentration of polymer mixture provided the highest protective and prolonged effect on the covering of fish oil. The particle sizes of less than 60 μm were obtained for all the formulations. The powder density was very suitable, which improves the flowability of the powder. Microencapsulation efficiency (69.16-74.75%) and surface morphology of encapsulated oil showed that the stability was increased and hence increased its acceptability as alternative primary polymers. PRACTICAL APPLICATIONSA relatively inexpensive and food-grade particles of encapsulated fish oil could be obtained, which are free from any organic solvents. Moreover, this process, parameters and technique could be facilitated in the food, pharmaceutical and nutraceutical industries.

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“…This may be attributed to the stronger hydrogen bonding between the carboxyl groups of the xanthan and the hydroxyl groups of guar gum, leading to stronger physical crosslinking between the polymers. Interaction between nonionic and ionic polymers has been reported to be greater than between molecules of the same species (Cerdeira et al, 1998).…”

Section: In-vitro Release Study Of Core Tabletsmentioning

confidence: 99%

Controlled release colon targeted drug delivery systems of non-steroidal anti-inflammatory drug, indomethacin

Elkhodairy¹

2013

Afr. J. Pharm. Pharmacol.

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This study aimed to investigate the efficacy of both xanthan gum (XG) and guar gum (GG) controlling the release rate of the poorly water soluble drug, indomethacin (IDM) from colon target drug delivery systems. Binary mixtures of the drug and the hydrophilic carrier (XG) in the ratios of 1:1 and 1:2 and tertiary mixture in the ratio of 1:1:1 IDM: XG: GG were prepared using three different approaches namely, physical mixture, co-grinding and solid dispersion. The prepared binary and tertiary systems were compressed into core tablets. The core tablets were evaluated for their drug content, weight variation, hardness, friability and in-vitro dissolution rate study. The dissolution profiles in pH 6.8 buffer solutions revealed that increasing the gum content in the core tablet resulted in a decrease in the IDM release rate. The core tablets were then coated with two different type of coat (inner and outer). The inner coat consisted of guar gum solutions of different concentrations (0.2, 0.4, 0.6, 0.8% w/v) to prevent the drug release in pH 7.4. Tablets were then coated with an enteric coat by dipping in 5% Eudragit (ER L100) ethanolic solution to inhibit the drug release in pH 1.2. The coated tablets were then dried using hot air. The prepared coated tablets were subjected to release rate study which indicated that the release of the drug was inhibited in pH 1.2 whereas; a low percentage of the drug was released in pH 7.4. In pH 6.8, the release profiles showed a sustained release of the drug over 18 h. The coated tablets that showed the promising sustained release profiles were further evaluated in pH 6.8 buffer solution containing rat cecal content to study the effect of bacterial degradation on the polysaccharide gums.

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Hydroxypropyl methylcellulose phthalate beads containing a model non-steroid anti-inflammatory drug

Cited by 12 publications

References 4 publications

Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method

Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method

Microencapsulation of Fish Oil Using Hydroxypropyl Methylcellulose As a Carrier Material by Spray Drying

Controlled release colon targeted drug delivery systems of non-steroidal anti-inflammatory drug, indomethacin

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