Hydroxypropylmethylcellulose films for the ophthalmic delivery of diclofenac sodium

El-Sousi, Salah; Nácher, Amparo; Mura, Carla; Catalán-Latorre, Ana; Merino, Virginia; Dı́ez-Sales, Octavio

doi:10.1111/j.2042-7158.2012.01587.x

Cited by 28 publications

(17 citation statements)

References 30 publications

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“…On the other hand, AFM enables capturing the topology of particles' surface on the image in nanometer resolution. All three methods are appropriate largely for specialistic application because of high equipment costs, low efficiency, and changing conditions of sample examination [57, 60–65]. …”

Section: Examinations Of Ophthalmic Drug Forms Propertiesmentioning

confidence: 99%

“…Both compartments are separated with a dialysis membrane, for example, made from cellophane. During examination, in specified time intervals, samples of dissolution medium are taken, and the medicinal substance is marked using a suitable analytical technique [55, 56, 65, 72]. …”

Section: Examinations Of Ophthalmic Drug Forms Propertiesmentioning

confidence: 99%

“…A sample for encapsulation efficiency examination is obtained by centrifuging [62, 64, 65] or centrifugal ultrafiltration [13, 44] of mixture formed after preparing the formulation. The obtained supernatant or filtrate is examined for amount of free active substance using a spectrophotometric method [44, 62, 64] or HPLC [13, 65].…”

Section: Examinations Of Ophthalmic Drug Forms Propertiesmentioning

confidence: 99%

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Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

Baranowski

Karolewicz

Gajda

et al. 2014

The Scientific World Journal

222

122

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This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. The rest of the paper describes recommended in vitro and in vivo studies to be performed for various ophthalmic drugs forms in order to assess whether the form is acceptable from the perspective of desired properties and patient's compliance.

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Section: Examinations Of Ophthalmic Drug Forms Propertiesmentioning

confidence: 99%

Section: Examinations Of Ophthalmic Drug Forms Propertiesmentioning

confidence: 99%

Section: Examinations Of Ophthalmic Drug Forms Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

Baranowski

Karolewicz

Gajda

et al. 2014

The Scientific World Journal

222

122

View full text Add to dashboard Cite

show abstract

“…Çà ïîñëåäíèå äåñÿòèëåòèÿ â äîïîëí åí èå ê òðà äèöèîí íûì îôòàëüìîëîãè÷åñêèì ïðåïàðàòàì (ãåëè, ìàçè, âîäíûå ñóñïåíçèè) áûëè ðàçðàáîòàíû îôòàëüìîëîãè÷åñêèå ïë åí êè, êîëë îèäí ûå ñ èñ òåìû, ñîñòîÿùèå èç íàíî-, ìèêðî÷àñòèö, íàíîýìóëüñèè, íàíîñóñïåíçèè. [15].…”

Section: ãèôåìà)unclassified

“…Ïî ñðàâíåíèþ ñ òðàäèöèîííîé ñóáêîíúþêòèâàëüíîé èíúåêöèåé, ïëåíî÷íûå ïîêðûòèÿ äåìîíñòðèðóþò áîëåå äë èòåë üí îå âîçäåéñ òâèå, âûñîêóþ áèîäîñòóïíîñòü äëÿ îáîëî÷åê ãëàçà [15].…”

Section: ãèôåìà)unclassified