Hydroxysafflor yellow A triggered a fast-to-slow muscle fiber-type conversion<i>via</i>regulating FoxO1 in myocytes

Sun, Yujie; Wang, Zhijun; Nie, Chenzhipeng; Li, Xue; Wang, Yu; Jinxin, Liu; Fan, Mingcong; Zhang, Duo; He, Ruikun; Zhang, Xuguang; Qian, Haifeng; Chow, Billy K. C.; Li, Yan; Wang, Li

doi:10.1039/d1fo03612b

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Prior to experiments, all mice raised underwent a 1 week adaptation period. The multiple conditions mice were kept in were similar to those described by Sun et al The mice were randomly divided into six groups: the control group, the TB-treated group, the WB-treated group, the concentration ratio of 1:2, the concentration ratio of 1:1, and the concentration ratio of 2:1. All mice were given one-time oral gavage.…”

Section: Methodsmentioning

confidence: 99%

Quercetin Enhances the Availability of 5-Heptadecylresorcinol by Inhibiting the Expression of P-gp

Jiang,

Zhang,

Fan

et al. 2023

J. Agric. Food Chem.

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5-Heptadecylresorcinol (AR-C17), as the most important active monomer, is found in large quantities in wheat and triticale and plays a variety of health benefits, such as antidiabetic, anti-inflammatory, and antitumor. However, the low bioavailability of AR-C17 due to its low water solubility restricts its application. Moreover, the transport mechanism of AR-C17 is not fully understood. Here, we showed that the transport of AR-C17 in vitro was time- and concentration-dependent, and relatively higher temperature and lower pH obviously promoted the transport of AR-C17. Besides, transporters, especially P-glycoprotein (P-gp), markedly affected the transport of AR-C17 as well. Quercetin, a natural synergist in triticale bran (TB), was confirmed as an inhibitor of P-gp to promote the transport of AR-C17 in this study, and the bioavailability of AR-C17 reached the highest when the concentration ratio of quercetin to AR-C17 was 1:1.

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Section: Methodsmentioning

confidence: 99%

Quercetin Enhances the Availability of 5-Heptadecylresorcinol by Inhibiting the Expression of P-gp

Jiang,

Zhang,

Fan

et al. 2023

J. Agric. Food Chem.

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Modifications and in vitro absorption of 5-heptadecyresorcinol from cereals using digestion and ussing chamber models

Jiang,

Chen,

Zhang

et al. 2024

Food Research International

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Hydroxysafflor yellow A triggered a fast-to-slow muscle fiber-type conversionviaregulating FoxO1 in myocytes

Abstract: Hydroxysafflor yellow A (HSYA) is the main bioactive component of safflower and has been reported to have significant health-promoting abilities.

Cited by 2 publications

References 44 publications

Quercetin Enhances the Availability of 5-Heptadecylresorcinol by Inhibiting the Expression of P-gp

Quercetin Enhances the Availability of 5-Heptadecylresorcinol by Inhibiting the Expression of P-gp

Modifications and in vitro absorption of 5-heptadecyresorcinol from cereals using digestion and ussing chamber models

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