2012
DOI: 10.1016/j.jsbmb.2011.08.002
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Hydroxysteroid dehydrogenases (HSDs) in bacteria – A bioinformatic perspective

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Cited by 103 publications
(90 citation statements)
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“…Another major microbial biotransformation of bile acids is the generation of oxo-(or keto-) bile acids by oxidation of hydroxyl groups at ring position 3, 7, or 12 that are catalyzed by bacteria with hydroxysteroid dehydrogenases (HSDHs), which are present in Actinobacteria, Proteobacteria, Firmicutes, and Bacteroidetes (Fukiya et al, 2009;Hirano and Masuda, 1981a;Kisiela et al, 2012;MacDonald et al, 1982;Sutherland and Macdonald, 1982). These oxidation reactions are reversible and can ultimately result in epimerization.…”
Section: Microbial Metabolism Of Bile Acidsmentioning
confidence: 99%
“…Another major microbial biotransformation of bile acids is the generation of oxo-(or keto-) bile acids by oxidation of hydroxyl groups at ring position 3, 7, or 12 that are catalyzed by bacteria with hydroxysteroid dehydrogenases (HSDHs), which are present in Actinobacteria, Proteobacteria, Firmicutes, and Bacteroidetes (Fukiya et al, 2009;Hirano and Masuda, 1981a;Kisiela et al, 2012;MacDonald et al, 1982;Sutherland and Macdonald, 1982). These oxidation reactions are reversible and can ultimately result in epimerization.…”
Section: Microbial Metabolism Of Bile Acidsmentioning
confidence: 99%
“…Our data thus suggested that in the denitrifying DHSTP sewage, testosterone was first transformed to other androgens via redox reactions by various microorganisms, including the initial Thauera spp. The redox transformations of steroids have been reported in numerous microorganisms, including bacteria (Kisiela et al, 2012) and fungi (Kristan and Rižner, 2012). For example, the 3-ketosteroid Δ 1 -dehydrogenase and cholesterol dehydrogenase of Stl.…”
Section: Discussionmentioning
confidence: 99%
“…Besides its critical role in steroid metabolism pathways, 3a-HSDs also serve as a useful enzyme in the determination of 3a-hydroxysteroids and relevant compounds [6,[21][22][23]. Although 3a-HSDs have been found in both eukaryotic cells and prokaryotes [12,13], their biological sources are very limited [23]. P. testosteroni 3a-HSD has been used in the detection of SBAs since the 1990s [5] and it is still the major biological source of 3a-HSD for clinical analysis.…”
Section: Discussionmentioning
confidence: 99%
“…In order to lower the enzyme cost, we intended to produce recombinant enzymes from new sources by a prokaryotic protein expression system. 3a-Hydroxysteroid dehydrogenase (3a-HSD) catalyzes the oxidation of the 3-hydroxyl group of steroids, which is present in animals and many steroid-degrading microorganisms [12,13]. Although 3a-HSDs had been cloned from several species, most of these efforts aimed to demonstrate their functions in steroid metabolism or hormone synthesis [14][15][16].…”
mentioning
confidence: 99%