Hydroxytyrosol and Its Potential Therapeutic Effects

Hu, Ting; He, Xin; Jiang, Jianguo; Xu, Xingyi

doi:10.1021/jf405820v

Cited by 170 publications

(131 citation statements)

References 53 publications

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“…Additionally this study shows higher levels of DOPAC from lipophilic nitroderivatives, NO 2 HTy-A and NO 2 HTy-E, in comparison with their precursor, NO 2 HTy. The chemical nature of the side chain substituent is emerging as an important factor in the biological activity of these compounds.…”

Section: Homovanillic Acid (Hva)mentioning

confidence: 50%

“…3). However, NO 2 HTy systemic administration produced a high increase in the striatal content of DOPAC, which was not statistically signicant (acute, 131.3% and chronic, 167.6%) (Fig. 3).…”

Section: -Dihydroxyphenylacetic Acid (Dopac)mentioning

confidence: 88%

“…2,3 HTy has the capacity to scavenge free radical species 4 as well as prompt the activity of antioxidant enzymes.…”

Section: Introductionmentioning

confidence: 99%

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The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

et al. 2014

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Hydroxytyrosol is a well-known phenolic compound with antioxidant properties that is found in virgin olive oil. Studies have shown that virgin olive oil has neuroprotective effects in rats; thus the purpose of the present study was to investigate the neuroprotective effect of hydroxytyrosol in rats. Additionally, this study aimed to investigate the neuroprotective potential of a homologous series of compounds with better lipophilic profiles in order to increase the assortment of compounds with a putative effect against ; i.p.) treatment of hydroxytyrosol and its nitroderivatives. For comparison, a commercial COMT inhibitor, Ro 41-0960, was also included. Our data show that acute and chronic systemic administration of these compounds produced a clear and statistically significant increase in the intracellular levels of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid. The increase in dopamine levels was very similar to the increase seen with Ro 41-0960 treatment. The effect of chronic treatment was stronger than that of acute treatment. With respect to the intracellular level of homovanillic acid, Ro 41-0960 produced a statistically significant decrease which it was not observed when hydroxytyrosol and its nitroderivatives were systemically administered. However, the chronic homovanillic acid treatment effect was stronger than the acute treatment. The results suggest that these compounds could inhibit COMT activity.

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Section: Homovanillic Acid (Hva)mentioning

confidence: 50%

Section: -Dihydroxyphenylacetic Acid (Dopac)mentioning

confidence: 88%

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The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

et al. 2014

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“…Among olive oil components, hydroxytyrosol (HTy) has featured in a number of review articles relating to its biochemical and pharmacological roles [9,16,31]. In accordance with this, the capacity of HTy to scavenge radical species [13] and to induce antioxidant enzymes [24] has been widely described.…”

Section: Introductionmentioning

confidence: 99%

Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis

et al. 2015

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“…There is currently a great deal of interest in the health benefits of hydroxytyrosol and its metabolites ( Figure 1) [13]. It would seem that this small molecule, in its natural state or as a hydrolysis product of several polyphenols, is easily absorbed in the intestine via a passive diffusion mechanism, bidirectionally and in a dose dependent manner [14].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of RP-HPLC-DAD Method to Quantify Hydroxytyrosol Content in a Semi-Solid Pharmaceutical Formulation

Smeriglio

Giovinazzo²,

Trombetta³

2015

Med chem

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Many substances of natural origin are contained in pharmaceutical and cosmetic formulations, but lately extra virgin olive oil (EVOO) or EVOO-derived compounds like tyrosol, hydroxytyrosol or oleuropein, thanks to their renowned and long-established outstanding therapeutic and health giving virtues, have made them some of the most interesting products in this field. Nowadays many hydroxytyrosol-based topical formulations are commercialized and over time several analytical methods have been developed. However, new cosmetic formulations containing an olive extract tritated in hydroxytyrosol conveyed in EVOO have recently appeared on the market creating the need to develop and validate a new method that allows the active compound to be extracted and analyzed precluding any interference due to the presence of other compounds naturally present in the EVOO as well as from the co-formulant agents employed, and this has been the goal of our study.Analytical determination was performed by RP-HPLC coupled with DAD detection. Various chromatographic parameters, namely column stationary phase, mobile phase, pH and solvent composition, oven temperature and different clean-up variables were studied. The best chromatographic separation was obtained under the following conditions: a reverse phase C18 column maintained at 25°C with a gradient elution program using acetic acid 0.2% and methanol as mobile phase pumped at 1.5 mL min −1 . Detection wavelength was set at 280 nm and the total run time required was 15 min. The high degree of accuracy (98.8%-100.1%) and precision (1.44%-1.68%) achieved using the evaluated method along with the low limits of detection and quantification (2.49 ppm and 3.97 ppm respectively) and the broad linear range observed allowed the target analyte to be satisfactorily determined in new semi-solid formulation containing hydroxytyrosol conveyed in EVOO while avoiding any matrix effect.

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Hydroxytyrosol and Its Potential Therapeutic Effects

Cited by 170 publications

References 53 publications

The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis

Development and Validation of RP-HPLC-DAD Method to Quantify Hydroxytyrosol Content in a Semi-Solid Pharmaceutical Formulation

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