Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice

Peng, Yunhua; Hou, Chen; Yang, Ziyin; Li, Caixia; Lee, Jia; Liu, Jing; Tang, Ying; Shi, Le; Li, Yongqin; Long, Jiangang; Liu, Jiankang

doi:10.1002/mnfr.201600332

Cited by 77 publications

(77 citation statements)

References 42 publications

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“…Although HT mildly benefited cognitive behaviour in APP/PS1 mice, it had no effect on brain Aβ accumulation. In addition, HT was associated with amended mitochondrial dysfunction, increased SOD‐2 expression, and reduced brain inflammatory markers (Y. Peng et al, ).…”

Section: Pharmacological and Nutraceutical Properties Of Htmentioning

confidence: 99%

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An overview of the pharmacology of olive oil and its active ingredients

Visioli

Dávalos

Hazas

et al. 2019

British J Pharmacology

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In addition to providing sensory stimuli, usually taste, smell and sight, olive oil contains a range of minor components, mostly phenolic in nature. These components are endowed with pharmacological or pharma‐nutritional properties that are the subject of active research worldwide. Based on our more than 25 years of experience in this field, we critically focus on what we believe are the most pharmacologically prominent actions of the constituents of olive oil. Most of the effects are due to the phenolic compounds in extra virgin olive oil, such as hydroxytyrosol and oleocanthal (which are often mis‐categorized as in vivo antioxidants) and concern the cardiovascular system. Other potentially beneficial activities are still to be investigated in depth. We conclude that—in the context of a proper diet that includes high‐quality products—the use of high‐quality olive oil contributes to achieving and sustaining overall health. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Pharmacological and Nutraceutical Properties Of Htmentioning

confidence: 99%

“…In addition, HT was associated with amended mitochondrial dysfunction, increased SOD-2 expression, and reduced brain inflammatory markers (Y. Peng et al, 2016).…”

Section: Neurological Disorders and Neurodegenerationmentioning

confidence: 99%

An overview of the pharmacology of olive oil and its active ingredients

Visioli

Dávalos

Hazas

et al. 2019

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Although many biological effects have been investigated, it has not been shown whether and how HT acts efficiently in AD progression. HT administered to 3‐month‐old female transgenic APP/PS1 mice at 5 mg/kg/day for 6 months resulted in electroencephalographic activity and cognitive function improvements and reductions in mitochondrial oxidative stress and neuroinflammation (Peng et al, ). In the same study, HT not only successfully rescued altered mitochondrial complex IV expression but also normalized mitochondrial complex I–IV activities compromised in this transgenic AD brain.…”

Section: Pharmacological Activators Of the Keap1/nrf2/are Pathway: A mentioning

confidence: 99%

“…Additionally, GSH depletion and HO‐1 and NQO‐1 upregulation observed in AD mice in response to Aβ‐induced oxidative stress were reversed by HT. Remarkably, APP/PS1 mice showed NF‐κB/MAPK‐dependent activation of NLRP3 inflammasome with increased IL‐6 and COX‐2 expression, which were significantly decreased by HT administration (Peng et al, ).…”

Section: Pharmacological Activators Of the Keap1/nrf2/are Pathway: A mentioning

confidence: 99%

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

Pennisi

Crupi

Paola

et al. 2016

J of Neuroscience Research

132

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Alzheimer disease (AD) is a progressive neurodegenerative disorder leading to cognitive decline, neuropsychiatric symptoms, disability, caregiver burden, and premature death. It represents the most prevalent cause of dementia, and its incidence rates exponentially increase with increasing age. The number of Americans living with AD is rapidly increasing. An estimated 5.4 million Americans of all ages have AD in 2016. One in nine people aged 65 and older has AD, and by midcentury, someone in the United States will develop the disease every 33 sec. It is now accepted that neuroinflammation is a common feature of neurological disease. Inflammasomes, which are a multiprotein complex part of the innate immune system, induce inflammation in response to various stimuli, such as pathogens and stress. Inflammasomes activate proinflammatory caspases, such as caspase-1, leading to the activation of the proinflammatory cytokines interleukin (IL)-1b, IL-18, and IL-33, which promote neuroinflammation and brain pathologies. The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing-3 (NLRP3) inflammasome is the best characterized in neurodegenerative diseases, in particular AD. Recent research suggests that NLRP3 could possibly be used in targeted therapies to alleviate neuroinflammation. Modulation of endogenous cellular defense mechanisms may be an innovative approach to therapeutic intervention in AD and other disorders associated with neuroinflammation and neurodegeneration. Herein, we introduce the hormetic dose-response concept and present possible mechanisms and applications to neuroprotection. We summarize the mechanisms involved in activation of the NLRP3 inflammasome and its role in neuroinflammation. We also address and propose the potential therapeutic utility of the nutritional antioxidants sulforaphane and hydroxytyrosol against particular signs and symptoms of AD. © 2016 Wiley Periodicals, Inc.

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“…Among the minor constituents of EVOO, a number of polyphenols and secoiridoids, including oleocanthal, hydroxytyrosol and oleuropein aglycone, are able to modulate many pathways that are relevant to the aging process. The beneficial effects of some components of EVOO in preventing and delaying the onset of AD, and in reducing the severity of its symptoms, have been found in transgenic mouse models 40,41 . On the other hand, the population cohort study, Nurses' Health Study, showed that greater adherence to the Mediterranean diet was associated with longer telomeres 42 .…”

Section: Lifestylesmentioning

confidence: 99%