Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells

Warleta, Fernando; Sánchez-Quesada, Cristina; Campos, María; Allouche, Yosra; Beltrán, Gabriel; Gaforio, José J.

doi:10.3390/nu3100839

Cited by 128 publications

(97 citation statements)

References 34 publications

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“…In contrast to these results showing the antiproliferative activity of HTyr, some authors have not detected any inhibition of cancer cell proliferation after HTyr treatment, also in the presence of HTyr-mediated reduction of oxidative cell damage [57,80,111]. These findings support the idea that, beyond the simple interference with radical processes, other mechanism(s) involving the specific interaction of HTyr with cellular target molecule(s) underlies HTyrmediated modulation of cell proliferation and apoptosis, and that further studies are necessary to elucidate the signaling events targeted by HTyr in cancer cell proliferation.…”

Section: Htyr-mediated Antiproliferative Activity and Cancermentioning

confidence: 48%

“…Furthermore, Fabiani et al [79] showed that HTyr (1-10 HM) prevented oxidative DNA damage in human normal blood mononuclear cells, and suggested that HTyr might efficiently prevent the initiation step of carcinogenesis in vivo, since the concentrations HTyr used could be easily reached with normal olive oil intake. It has been also shown [80] that HTyr (6.25-100 HM) reduced basal and H 2 O 2 -induced ROS levels in the immortalized nontumorigenic MCF10A human breast epithelial cell line. All these results suggest that HTyr, inhibiting ROS production, can prevent oxidative DNA damage in normal and non-transformed cells in vitro, thereby preventing the initiation of a chain of reactions that transforms normal into cancer cells Fig.…”

Section: The Direct Antioxidant Activity Of Htyr Was Demonstrated In mentioning

confidence: 99%

“…These results strongly suggest that HTyr has a significantly protective effect against UVB-induced oxidative DNA damage. Moreover, it has been shown that HTyr, at potential physiological concentrations (1-100 HM), protects other different cancer cell types, such as those derived from gut [83], blood [84], prostate [57], and breast [80], against oxidative damage induced by H 2 O 2. This means, as discussed above, that HTyr might also protect tumor cells from the cytotoxic/proapoptotic action of some chemotherapeutic agents.…”

Section: The Direct Antioxidant Activity Of Htyr Was Demonstrated In mentioning

confidence: 99%

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Naturally Occurring Hydroxytyrosol: Synthesis and Anticancer Potential

Bernini¹,

Merendino²,

Romani³

et al. 2013

CMC

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Several epidemiological and animal studies have suggested that polyphenols, a group of secondary plant metabolites occurring mainly in the plant kingdom, may have a protective effect against some chronic degenerative diseases such as cancer. Polyphenols are part of the human diet, being present in vegetal food and beverages. Among them, an olive biophenol named hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol, HTyr] has recently received particular attention because of its antioxidant, antiproliferative, pro-apoptotic, and anti-inflammatory activities, which have the potential to specifically counteract all cancer hallmarks, thus representing the expectant biological activities underlying the anti-tumor properties of this polyphenol. After a description of the synthetic procedures to prepare pure HTyr, this review takes into consideration the chemopreventive and chemotherapeutic potential of HTyr as the result of its antioxidant, antiproliferative and anti-inflammatory activities. In particular, the review is focused on the current knowledge of the main cellular and molecular mechanisms used by HTyr to affect carcinogenesis, highlighting the specific oncogenic and inflammatory signaling pathways potentially targeted by HTyr.

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Section: Htyr-mediated Antiproliferative Activity and Cancermentioning

confidence: 48%

Section: The Direct Antioxidant Activity Of Htyr Was Demonstrated In mentioning

confidence: 99%

Section: The Direct Antioxidant Activity Of Htyr Was Demonstrated In mentioning

confidence: 99%

See 1 more Smart Citation

Naturally Occurring Hydroxytyrosol: Synthesis and Anticancer Potential

Bernini¹,

Merendino²,

Romani³

et al. 2013

CMC

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“…Two of the major antioxidants that have been studied in relation to breast cancer prevention are hydroxtyrosol and tyrosol. One recent study demonstrated that hydroxtyrosol is a more potent antioxidant than tyrosol due to its ability to lower the concentration of reactive oxygen species (ROS) in MCF10A cells more compared with tyrosol (Warleta et al, 2011). Furthermore, they also showed that hydroxtyrosol was able to prevent oxidative DNA damage in three breast cancer cell lines while tyrosol did not.…”

Section: 2207 Mechanics Behind Breast Cancer Prevention -Focus On Obmentioning

confidence: 73%

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Alegre¹,

Knowles²,

Robison³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cancer prevention is rapidly emerging as a major strategy to reduce cancer mortality. In the field of breast cancer, significant strides have recently been made in the understanding of underlying preventive mechanisms. Currently, three major strategies have been linked to an increase in breast cancer risk: obesity, lack of physical exercise, and high levels of saturated dietary fat. As a result, prevention strategies for breast cancer are usually centered on these lifestyle factors. Unfortunately, there remains controversy regarding epidemiological studies that seek to determine the benefit of these lifestyle changes. We have identified crucial mechanisms that may help clarify these conflicting studies. For example, recent reports with olive oil have demonstrated that it may influence crucial transcription factors and reduce breast tumor aggressiveness by targeting HER2. Similarly, physical exercise reduces sex hormone levels, which may help protect against breast cancer. Obesity promotes tumor cell growth and cell survival through upregulation of leptin and insulin-like growth factors. This review seeks to discuss these underlying mechanisms, and more behind the three major prevention strategies, as a means of understanding how breast cancer can be prevented.

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“…The effects of LACHI MIX HT were examined on oxidative stress levels, chloride and potassium channel conductances and excitability of the sarcolemma, calcium homeostasis and contractile function, muscle atrophy, and muscle force, all of which are sensitive to the activity of ROS. The effects of LACHI MIX HT were compared with those of purified HT, already proposed in different therapies, i.e., anticancer or cardioprotective (Granados-Principal et al 2010;Warleta et al 2011;Castañer et al 2012). …”

Section: Introductionmentioning

confidence: 99%

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Pierno

Tricarico

Liantonio

et al. 2013

AGE

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Age-related skeletal muscle decline is characterized by the modification of sarcolemma ion channels important to sustain fiber excitability and to prevent metabolic dysfunction. Also, calcium homeostasis and contractile function are impaired. In the aim to understand whether these modifications are related to oxidative damage and can be reverted by antioxidant treatment, we examined the effects of in vivo treatment with an waste water polyphenolic mixture (LACHI MIX HT) supplied by LACHIFARMA S.r.l. Italy containing hydroxytirosol (HT), gallic acid, and homovanillic acid on the skeletal muscles of 27-month-old rats. After 6-week treatment, we found an improvement of chloride ClC-1 channel conductance, pivotal for membrane electrical stability, and of ATP-dependent potassium channel activity, important in coupling excitability with fiber metabolism. Both of them were analyzed using electrophysiological techniques. The treatment also restored the resting cytosolic calcium concentration, the sarcoplasmic reticulum calcium release, and the mechanical threshold for contraction, an index of excitation-contraction coupling mechanism. Muscle weight and blood creatine kinase levels were preserved in LACHI MIX HT-treated aged rats. The antioxidant activity of LACHI MIX HT was confirmed by the reduction of malondialdehyde levels in the brain of the LACHI MIX HT-treated aged rats. In comparison, the administration of purified HT was less effective on all the parameters studied. Although muscle function was not completely recovered, the present study provides evidence of the beneficial effects of LACHI MIX HT, a natural compound, to ameliorate skeletal muscle functional decline due to aging-associated oxidative stress.

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Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells

Cited by 128 publications

References 34 publications

Naturally Occurring Hydroxytyrosol: Synthesis and Anticancer Potential

Naturally Occurring Hydroxytyrosol: Synthesis and Anticancer Potential

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

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