Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases

Pablos, Rocío M. de; Espinosa-Oliva, Ana M.; Hornedo-Ortega, Ruth; Cano, Mercedes; Argüelles, Sandro

doi:10.1016/j.phrs.2019.03.005

Cited by 111 publications

(73 citation statements)

References 177 publications

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“…Thus, the MedDiet appears to be a valuable diet for “healthy aging” (defining this process as the longest possible absence of pathological phenomena, including decreased cognitive performance). Many of the previously described effects of MedDiet ingredients can also be considered from the perspective of healthy aging, for example, its effects on AMPK, SIRT1, or mTOR (de Pablos, Espinosa‐Oliva, Hornedo‐Ortega, Cano, & Arguelles, ; Johnson, Sangesland, Kaeberlein, & Rabinovitch, ; Moreno‐Blas, Gorostieta‐Salas, & Castro‐Obregón, ).…”

Section: Agingmentioning

confidence: 99%

Mediterranean diet and health status: Active ingredients and pharmacological mechanisms

Schwingshackl

Morze

Hoffmann

2019

British J Pharmacology

228

131

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The Mediterranean diet (MedDiet) is one of the most widely described and evaluated dietary patterns in scientific literature. It is characterized by high intakes of vegetables, legumes, fruits, nuts, grains, fish, seafood, extra virgin olive oil, and a moderate intake of red wine. A large body of observational and experimental evidence suggests that higher adherence to the MedDiet is associated with lower risk of mortality, cardiovascular disease, metabolic disease, and cancer. Current mechanisms underlying the beneficial effects of the MedDiet include reduction of blood lipids, inflammatory and oxidative stress markers, improvement of insulin sensitivity, enhancement of endothelial function, and antithrombotic function. Most likely, these effects are attributable to bioactive ingredients such as polyphenols, monounsaturated and polyunsaturated fatty acids, or fibre. This review will focus on both established and less established mechanisms of action of biochemical compounds contained in a MedDiet. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Agingmentioning

confidence: 99%

Mediterranean diet and health status: Active ingredients and pharmacological mechanisms

Schwingshackl

Morze

Hoffmann

2019

British J Pharmacology

228

131

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“…NADPH oxidase is an enzymatic complex consisting of several subunits, including cytosolic subunits (p40 phox , p47 phox , and p67 phox ), the membrane bound cytochrome b558 (p22 phox ), the heme binding enzymatic subunit (gp91 phox ), and the Rac G-protein [31]. After a pathogenic stimulus, the different subunits of the NADPH oxidase associate, leading to its activation and ROS production [32]. The expression levels of p22 phox , p47 phox , and gp91 phox subunits of the enzyme were measured by RT-PCR to study the effect of HT on the LPS-and α-syn-induced oxidative stress.…”

Section: Effect Of Ht On the Induction Of Nadph Oxidase And Ros Produmentioning

confidence: 99%

Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro

et al. 2019

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I.M.A.-B.); rodriguez@us.es (J.A.R.-G.); jlvenero@us.es (J.L.V.); depablos@us.es (R.M.d.P.)Abstract: Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson's disease (PD), and seems to play a key role in their development and progression. Microglia cells, the principal orchestrators of neuroinflammation, can be polarized in different phenotypes, which means they are able to have anti-inflammatory, pro-inflammatory, or neurodegenerative effects. Increasing evidence supports that the traditional Mediterranean dietary pattern is related to the reduction of cognitive decline in neurodegenerative diseases. A considerable intake of plant foods, fish, and extra virgin olive oil (EVOO), as well as a moderate consumption of red wine, all characteristic of the Mediterranean diet (MD), are behind these effects. These foods are especially rich in polyphenols, being the most relevant in the MD hydroxytyrosol (HT) and their derivatives present in EVOO, which have demonstrated a wide array of biological activities. Here, we demonstrate that HT is able to reduce the inflammation induced by two different stimuli: lipopolysaccharide and α-synuclein. We also study the possible molecular mechanisms involved in the anti-inflammatory effect of HT, including the study of nuclear factor kappa B (NF-κB), mitogen-activated protein kinases (MAPKs), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and inflammasome. Our data support the use of HT to prevent the inflammation associated with PD and shed light into the relationship between MD and this neurological disorder.

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“…Other mechanisms of action have been proposed for HT and olive phenolics (de Pablos, Espinosa‐Oliva, Hornedo‐Ortega, Cano, & Arguelles, ). Probably, the most important one concerns inflammation.…”

Section: Pharmacological and Nutraceutical Properties Of Htmentioning

confidence: 99%

An overview of the pharmacology of olive oil and its active ingredients

Visioli

Dávalos

Hazas

et al. 2019

British J Pharmacology

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In addition to providing sensory stimuli, usually taste, smell and sight, olive oil contains a range of minor components, mostly phenolic in nature. These components are endowed with pharmacological or pharma‐nutritional properties that are the subject of active research worldwide. Based on our more than 25 years of experience in this field, we critically focus on what we believe are the most pharmacologically prominent actions of the constituents of olive oil. Most of the effects are due to the phenolic compounds in extra virgin olive oil, such as hydroxytyrosol and oleocanthal (which are often mis‐categorized as in vivo antioxidants) and concern the cardiovascular system. Other potentially beneficial activities are still to be investigated in depth. We conclude that—in the context of a proper diet that includes high‐quality products—the use of high‐quality olive oil contributes to achieving and sustaining overall health. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases

Cited by 111 publications

References 177 publications

Mediterranean diet and health status: Active ingredients and pharmacological mechanisms

Mediterranean diet and health status: Active ingredients and pharmacological mechanisms

Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro

An overview of the pharmacology of olive oil and its active ingredients

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