Hydroxyurea inhibition of cellular and developmental activities in the decidualized and pregnant uteri of rats

Spencer, Fitzgerald; Chi, Limen; Zhu, Maoshu

doi:10.1002/1099-1263(200009/10)20:5<407::aid-jat704>3.0.co;2-t

Cited by 13 publications

(12 citation statements)

References 34 publications

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“…Studies in rats showed an increase in post‐implantation losses, and reduced fetal and placental weights (Spencer et al, 2000). Despite strict instructions to take contraceptive precautions for both men and women patients on treatment, there have been a number of pregnancies in published studies.…”

Section: Pregnancy and Teratogenicitymentioning

confidence: 99%

The role of hydroxyurea in sickle cell disease

2003

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Section: Pregnancy and Teratogenicitymentioning

confidence: 99%

The role of hydroxyurea in sickle cell disease

2003

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“…Spencer et al ( 2000 ) , supported by NIH, examined developmental toxicity in rats exposed to hydroxyurea. Decidualization responses in pregnant rats were also examined and are discussed in Section 4.2.…”

Section: 0 Developmental Toxicity Datamentioning

confidence: 99%

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of hydroxyurea

Liebelt

Balk

Faber³

et al. 2007

Birth Defects Research Pt B

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“…In addition, hydroxyurea causes a significant decrease in developmental progress of rodent embryo (28). In correlation with the in vivo result in which hydroxyurea exhibited anti-proliferative activity on decidua of pregnant rats (37), the embryotoxicity of hydroxyurea is indicative of reduction of cell viability and inhibition of differentiation. In addition, the anti-cancer drugs used (hydroxyurea, 5-fluorouracil, and cytosine arabinoside) have been reported to reduce implantation rate and fetal/placental weight (37-39).…”

Section: Developmental Toxicants On Differentiated Mouse Es Cellsmentioning

confidence: 67%

Assessment of Developmental Toxicants using Human Embryonic Stem Cells

Hong¹,

Jeung²

2013

Toxicological Research

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Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid bodies (EBs). In earlier study, embryonic stem cell test (EST) was established for assessment of the embryotoxic potential of compounds. Using EBs indicating the onset of differentiation of mouse ES cells, many toxicologists have refined the developmental toxicity of a variety of compounds. However, due to some limitation of the EST method resulting from species-specific differences between humans and mouse, it is an incomplete approach. In this regard, we examined the effects of several developmental toxic chemicals on formation of EBs using human ES cells. Although human ES cells are fastidious in culture and differentiation, we concluded that the relevancy of our experimental method is more accurate than that of EST using mouse ES cells. These types of studies could extend our understanding of how human ES cells could be used for monitoring developmental toxicity and its relevance in relation to its differentiation progress. In addition, this concept will be used as a model system for screening for developmental toxicity of various chemicals. This article might update new information about the usage of embryonic stem cells in the context of their possible ability in the toxicological fields.

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Hydroxyurea inhibition of cellular and developmental activities in the decidualized and pregnant uteri of rats

Cited by 13 publications

References 34 publications

The role of hydroxyurea in sickle cell disease

The role of hydroxyurea in sickle cell disease

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of hydroxyurea

Assessment of Developmental Toxicants using Human Embryonic Stem Cells

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