Hygienic rationing of flupyradifurone and justification of safe use regulations of flupyradifurone-based insecticide to protect vineyards, apple, pear trees and cabbage

Abstract

ABSTRACT. Flupyradifurone is an insecticide recommended to protect vineyards, apple, pear trees and cabbage in agriculture. For the state registration in Ukraine, toxicological and hygienic assessment of flupyradifurone and its insecticidal product Sivanto Prime 200 SL was performed. Acceptable daily intake of flupyradifurone for human was justified at the level of 0.02 mg/kg; hygienic standards for flupyradifurone and regulations for the safe use of insecticide Sivanto Prime 200 SL, in agriculture were developed. Objective. Toxicological and hygienic assessment of flupyradifurone and its insecticidal preparation, evaluation of the risk of rural labourers and population exposure. Methods. Expert and analytical, toxicological, physical and chemical, statistical and hygienic. Results. Based on acute toxicity parameters for different ways of exposure, flupyradifurone and Sivanto Prime 200 SL are rated as hazard class II. Long-term effects (carcinogenicity, mutagenicity and teratogenicity, reproductive and developmental toxicity) are not limiting criteria when assessing flupyradifurone hazard. Field trials have shown that residual flupyradifurone was not detectable in grapes, apples, pears and cabbage during harvesting. Occupational risk degree under inhalation and cutaneous exposure of labours to flupyradifurone was within the acceptable level. Conclusion. Use of flupyradifurone-based insecticide Sivanto Prime 200 SL for the protection of vineyards, apple, pear trees and cabbage as per agricultural and hygienic standards and regulations will not lead to contamination of agricultural products and environmental objects and will be safe for the population. Keywords: insecticide, flupyradifurone, toxicological properties, hygienic standards and regulations, hazard assessment.