Hygienic safety of an ultrasonic flow sensor for multiple breath washout

Fuchs, Susanne; Gappa, Monika; Waltner-Romen, Maria; Ellemunter, Helmut

doi:10.1002/ppul.20941

Cited by 11 publications

(9 citation statements)

References 4 publications

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“…An MBW device using a sidestream ultrasonic flow sensor ( EasyOne Pro, MBW Module , ndd Medical Technologies, Zurich, Switzerland) which has the potential of being used in clinical routine was validated in a stepwise single center validation program and the prototype has now reached a status allowing use in a multi‐center study setting 15, 19–23…”

Section: Introductionmentioning

confidence: 99%

Feasibility and Variability of Measuring the Lung Clearance Index in a Multi‐Center Setting

Fuchs

Ellemunter

Eder

et al. 2011

Pediatric Pulmonology

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The Lung Clearance Index (LCI) is superior to spirometry in detecting early lung disease in cystic fibrosis (CF) and correlates with structural lung changes seen on CT scans. The LCI has the potential to become a novel outcome parameter for clinical and research purposes. However longitudinal studies are required to further prove its prognostic value. Multi-center design is likely to facilitate realization of such studies. Therefore the aim of the present study was to assess multi-center feasibility and inter-center variability of LCI measurements in healthy children and adolescents. Comparative measurements were performed in unselected patients with CF to confirm previous single-center results. LCI measurements were performed in eight centers using the EasyOne Pro, MBW Module (ndd Medical Technologies, Zurich, Switzerland). The overall success rate for LCI measurements was 75.5%, leaving 102/151 measurements in healthy volunteers and 139/183 measurements in patients with CF for final analysis. Age ranged between 4 and 24 years. Mean LCI (range of means among centers) was 6.3 (6.0-6.5) in healthy volunteers and thus normal. Inter-center variability of center means was 2.9%, ANOVA including Schffé procedure demonstrated no significant inter-center differences (P > 0.05). Mean LCI (range of means among centers) was 8.2 (7.4-8.9) in CF and thus abnormal. Our study demonstrates good multi-center feasibility and low inter-center variability of the LCI in healthy volunteers when measured with the EasyOne Pro MBW module. Our data confirm published LCI data in CF. However, central coordination, quality control, regular training, and supervision during the entire study appear essential for successfully performing multi-center trials.

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Section: Introductionmentioning

confidence: 99%

Feasibility and Variability of Measuring the Lung Clearance Index in a Multi‐Center Setting

Fuchs

Ellemunter

Eder

et al. 2011

Pediatric Pulmonology

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“…The genotyping success rate exceeded 90%, and both SNPs were in the Hardy-Weinberg equilibrium. Data pertaining to FEV1 associations with both SNPs and the surrounding region were obtained from published online data of the 1958 birth cohort [4].…”

Section: To the Editorsmentioning

confidence: 99%

“…No associations were seen with rs3087243. In data deposited by J. Todd (University of Cambridge, Cambridge, UK) and published online by the 1958 birth cohort [4], rs231775 tended to be associated with FEV1, such that those with the G allele had lower FEV1 compared with AA homozygotes (B5 -0.053, 95% CI -0.101--0.005; p50.09). An SNP just 4 kb towards the 59 end of the gene from rs231775 was significantly associated (B50.098, 95% CI 0.032 -0.163; p50.01).…”

Section: To the Editorsmentioning

confidence: 99%

CTLA4 polymorphisms and COPD: Table 1—

Wood

Newby

Gough³

et al. 2010

Eur Respir J

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“…The cross-contamination between patients can be minimized by cleaning and using disposable inserts [53] and following specific CF guidelines on infection prevention and control [54]. LCI tests with different end-points (e.g.…”

Section: Introductionmentioning

confidence: 99%

Lung clearance index in subjects with cystic fibrosis in Italy

et al. 2019

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The Lung Clearance Index (LCI) is an index derived from washout recordings, able to detect early peripheral airway damage in subjects with cystic fibrosis (CF) with a greater sensitivity than spirometry. LCI is a marker of overall lung ventilation inhomogeneity; in fact, as pulmonary ventilation worsens, the number of tidal breaths and the expiratory volumes required to clear the lungs of a marker gas are increased, as documented by a greater value. In the field of CF, LCI allows indirect investigation of the small airways (< 2 mm) the site where, from a pathophysiologic point of view, the disease begins due to the defect of the CF transmembrane-conductance regulator (CFTR) protein. Infant pulmonary function changes seem to occur before clinically overt symptoms of lower respiratory illness occur. When performing the test, it is important to refer to the American Thoracic Society and European Respiratory Society consensus statements and apply a strict standardization. In Italy the first tests were carried out in 2014 for research purpose and now approximately 10 centers are collecting data and are experiencing a consistency in repeating exams. Currently in Italian centers children at pre-school age are the main target: in this population it is important to have a sensitive and feasible test, non-invasive, that can be performed at tidal volume without sedation, and requiring minimal cooperation and coordination, and that can be used longitudinally over time. Another target could be the transplanted subjects to detect early signs of lung function decline. The content of this paper captures the experience and discussions among some of the Italian centers where LCI is currently used for research and/or in clinical practice about the method and the need to have a common approach. The aim of this paper is not to describe the methodology of MBW, but to inform the pediatric community about the possible application of LCI in CF.

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Hygienic safety of an ultrasonic flow sensor for multiple breath washout

Cited by 11 publications

References 4 publications

Feasibility and Variability of Measuring the Lung Clearance Index in a Multi‐Center Setting

Feasibility and Variability of Measuring the Lung Clearance Index in a Multi‐Center Setting

CTLA4 polymorphisms and COPD: Table 1—

Lung clearance index in subjects with cystic fibrosis in Italy

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