Hygroscopicity of a sugarless coating layer formed by the interaction between mannitol and poly(vinyl alcohol) (PVA)

Higuchi, Masaharu; Tanaka, Syunichi; Tamura, Koichi; Sakata, Yukoh

doi:10.1016/j.colsurfb.2014.09.058

Cited by 11 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absorption peak of OH in PVA/DB composites shifted to higher wavenumbers, which indicated that OH of DM could form intermolecular hydrogen bonds with OH of PVA. The similar conclusion was found in the study by M. Higuchi [30] . With the further increase of DB(≤50 wt%), PVA/DB composites almost showed the characteristic absorption peaks of DM, BMIMBr and PVA.…”

Section: Resultssupporting

confidence: 90%

“…The broad peak of OH in PVA/DB composites shifted to higher wavenumbers (3421 cm −1 ). This was interpreted in that newly‐formed H‐bonds between both hydroxyl groups of DM and anions (Br − ) of BMIMBr and hydroxyl groups of PVA broke the original intra‐or intermolecular hydrogen bonds of PVA [20,30] . Their combined effects caused the higher wavenumber of OH in PVA/DB composites.…”

Section: Resultsmentioning

confidence: 99%

“…The similar conclusion was found in the study by M. Higuchi. [30] With the further increase of DB(� 50 wt %), PVA/DB composites almost showed the characteristic absorption peaks of DM, BMIMBr and PVA. The broad peak of OH in PVA/DB composites shifted to higher wavenumbers (3421 cm À 1 ).…”

Section: Interactions Between Pva and Dbmentioning

confidence: 92%

See 2 more Smart Citations

Influence of Complex Plasticizer on Plasticizing Effects and Rheological Properties of Plasticized Poly(Vinyl Alcohol)

Wang,

Zou,

Wang

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Poly(vinyl alcohol) (PVA) was modified using D‐mannitol (DM) and 1‐butyl‐3‐methylimidazole bromide (BMIMBr) as the complex plasticizer (DB), and PVA/DB composite was prepared. The plasticizing effect of DB on PVA was studied by Fourier transform infrared spectroscopy (FT‐IR), differntial scanning calorimetry (DSC), thermos gravimetric analysis (TGA) and melt flow indexer (MI). FT‐IR analysis indicated that Br− of BMIMBr and OH of DM could form H‐bonds with OH of PVA. With the increase of DB, the melt temperature (Tm2) and crystallization temperature (Tc1) of PVA/DB composite decreased, the initial thermal decomposition temperatures (Td), thermal processing window (ΔT) and MI values increased respectively. Based on above studies, the influence of DB content on rheological properties of PVA/DB composite was investigated by the capillary rheometer. The result displayed that apparent viscosity of PVA/DB composite decreased with increasing DB content, shear rate and measured temperature. The non‐Newtonian index (n) increased and structural viscosity index (Δη) decreased with the increase of measured temperature and DB. The viscous flow activation energy (Eη) decreased as the shear rate and DB content increased. When the measured temperature, DB content and shear rate were in the range of Tm2+30 −Tm2+35 °C, 40–50 wt% and 764.8–1504.9 s−1, respectively, the spinnability of PVA/DB composite was optimal, which will lay a theoretical foundation for the exploration of melt spinning process in the future.

show abstract

Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Complex Plasticizer on Plasticizing Effects and Rheological Properties of Plasticized Poly(Vinyl Alcohol)

Wang,

Zou,

Wang

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…Aside from PVP, Higuchi, Tanaka, Tamura and Sakata [ 30 ] introduced a coating layer comprising PVA and sweetener mannitol to protect the tablets from moisture and to mask their unpleasant taste. From their study, they found that the moisture absorption rate of the PVA/mannitol layer at concentration ratio of 15:2.5–15:4 ( w / w ) (smoothest surface) on natural antioxidant L-cysteine was lowest compared with PVA-film-coated and uncoated tablets.…”

Section: Formulation Strategies To Reduce or Control Hygroscopicitymentioning

confidence: 99%

Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly Hygroscopic Pharmaceuticals and Nutraceuticals

Ling

Hadinoto

2022

Pharmaceutics

View full text Add to dashboard Cite

Highly hygroscopic pharmaceutical and nutraceutical solids are prone to significant changes in their physicochemical properties due to chemical degradation and/or solid-state transition, resulting in adverse effects on their therapeutic performances and shelf life. Moisture absorption also leads to excessive wetting of the solids, causing their difficult handling during manufacturing. In this review, four formulation strategies that have been employed to tackle hygroscopicity issues in oral solid dosage forms of pharmaceuticals/nutraceuticals were discussed. The four strategies are (1) film coating, (2) encapsulation by spray drying or coacervation, (3) co-processing with excipients, and (4) crystal engineering by co-crystallization. Film coating and encapsulation work by acting as barriers between the hygroscopic active ingredients in the core and the environment, whereas co-processing with excipients works mainly by adding excipients that deflect moisture away from the active ingredients. Co-crystallization works by altering the crystal packing arrangements by introducing stabilizing co-formers. For hygroscopic pharmaceuticals, coating and co-crystallization are the most commonly employed strategies, whereas coating and encapsulation are popular for hygroscopic nutraceuticals (e.g., medicinal herbs, protein hydrolysates). Encapsulation is rarely applied on hygroscopic pharmaceuticals, just as co-crystallization is rarely used for hygroscopic nutraceuticals. Therefore, there is potential for improved hygroscopicity reduction by exploring beyond the traditionally used strategy.

show abstract

“…[13,14] Last but not least, PVA molecules possess a lot of hydroxyl groups to form both intraand intermolecular hydrogen bonds with amine or hydroxyl groups (or epoxy groups in our case), thus facilitating the compatibility between microcapsules and coating substrate to improve the dispersion of microcapsules into coating substrate. [15] As the aforementioned merits, this paper would suggest a new combination of reactants in the oil-inwater emulsion polymerization process to fabricate microcapsules, resulting in a higher core content to apply in self-healing epoxy coatings covering metals such as steel and iron. Furthermore, the self-healing property of microcapsule-containing epoxy coating was thoroughly demonstrated through the anticorrosive ability in the NaCl solution.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of polyurethane/polyurea microcapsules carrying diisocyanate in self‐healing epoxy coating

Mai,

Ha,

Oanh

2022

Vietnam Journal of Chemistry

View full text Add to dashboard Cite

Recently, self‐healing coating has been emerged and become one of the most crucial and critical materials with an excellent potential to repair physical damage and prevent cracks from expansion as an anticorrosion element to lengthen the coating lifespan. The determining factor in self‐healing coating is that the microcapsules containing a self‐curing liquid, which quickly fills up the cracks when the coatings are cut. Microcapsule embracing isophorone diisocyanate (IPDI) as a strong self‐healing agent requiring no catalyst has been continuously innovated to be utilized in reality; however, its core content is still low (50‐70 %) and the effects on it were not systematically investigated. Therefore, this study aimed to synthesize polyurethane/polyurea microcapsules carrying a higher content of IPDI to be potentially applied in self‐healing epoxy coating. As a result, the newly developed spherical microcapsules were obtained with a core content of nearly 80 %, which is far higher than previous research. Moreover, the self‐healing ability of epoxy coating containing 10 wt.% of these microcapsules was apparently demonstrated as illustrated in SEM images, along with its excellent anticorrosion, preventing 92.5 % of cracks from corrosion after immersed in 3.5 % NaCl solution for 72 hours.

show abstract

Hygroscopicity of a sugarless coating layer formed by the interaction between mannitol and poly(vinyl alcohol) (PVA)

Cited by 11 publications

References 25 publications

Influence of Complex Plasticizer on Plasticizing Effects and Rheological Properties of Plasticized Poly(Vinyl Alcohol)

Influence of Complex Plasticizer on Plasticizing Effects and Rheological Properties of Plasticized Poly(Vinyl Alcohol)

Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly Hygroscopic Pharmaceuticals and Nutraceuticals

Synthesis of polyurethane/polyurea microcapsules carrying diisocyanate in self‐healing epoxy coating

Contact Info

Product

Resources

About