Hymenialdisine is Cytotoxic Against Cisplatin-Sensitive but not Against Cisplatin-Resistant Cell Lines

Abstract

New compounds are needed to overcome the resistance to commonly used cytotoxic chemotherapy for epithelial ovarian cancer. Marine sponges are a rich source of diverse chemical compounds, and hymenialdisine has been found to have antiproliferative effects. We investigated the cytotoxic effect of hymenialdisine in cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines. Methods: The anti-cancer effects of hymenialdisine or cisplatin were assessed by treating cells with different concentrations of hymenialdisine and cisplatin. Cell viability was determined using the AlamarBlue® Assay. Results: The IC50 of cisplatin was estimated at 31.4 μM for A2780S and 76.9 μM for A2780CP, whereas the IC50 of hymenialdisine was evaluated at 146.8 μM for A2780S cells. Despite the higher concentrations of hymenialdisine (up to 300 μM), IC50 could not be determined for the A2780CP cell line. Conclusion: When compared to cisplatin, hymenialdisine was less toxic against both A2780S and A2780CP ovarian cancer cell lines.
 Keywords: Ovarian Cancer, Marine compounds, Cisplatin, Hymenialdisine, Oman

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