Hyoscine patch withdrawal syndrome in a returned traveller

Wahl, Gareth; Vlad, Ioana

doi:10.1111/1742-6723.13624

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…This syndrome is particularly prevalent with Intrathecal Baclofen Therapy (ITB) therapy, especially in patients with hepatic and renal dysfunctions, necessitating cautious dose adjustments and vigilant monitoring. Scopolamine patches, used primarily for motion sickness prevention, have been associated with withdrawal symptoms, including exacerbated motion sickness or headaches, as reported in several case studies ( Lau and Vaneaton, 2014 ; Chowdhury et al, 2017 ; Wahl and Vlad, 2020 ). These symptoms typically manifest after three or more days of continuous use and are generally self-limiting without leading to severe consequences.…”

Section: Discussionmentioning

confidence: 97%

Evaluating drug withdrawal syndrome risks through food and drug administration adverse event reporting system: a comprehensive disproportionality analysis

Zhang,

Yang,

Chen

et al. 2024

Front. Pharmacol.

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ObjectiveThe study aims to identify the drugs associated with drug withdrawal syndrome in the Food and Drug Administration Adverse Event Reporting System (FAERS) and estimate their risks of causing withdrawal syndrome.MethodsAll the data were collected from FAERS from the first quarter of 2004 to the third quarter of 2023. Disproportionality analyses of odds ratio (ROR) and proportional reported ratio were conducted to identify potential adverse effects signal of drug withdrawal syndrome.ResultsA total of 94,370 reports related to withdrawal syndrome from the data. The top 50 drugs with most frequency reported were analyzed, and 29 exhibited a positive signal based on the number of reports. The top three categories of drugs with positive signals included opioids, antidepressant drugs and antianxiety drugs. Other classifications included opioid antagonist, muscle relaxant, antiepileptic drugs, analgesics, hypnotic sedative drugs and antipsychotic drugs.ConclusionOur analysis of FAERS data yielded a comprehensive list of drugs associated with withdrawal syndrome. This information is vital for healthcare professionals, including doctors and pharmacists, as it aids in better recognition and management of withdrawal symptoms in patients undergoing treatment with these medications.

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Section: Discussionmentioning

confidence: 97%