Hyperacute Radiation Pneumonitis

Goldman, Allan L.; Enquist, Robert W.

doi:10.1378/chest.67.5.613

Cited by 18 publications

(3 citation statements)

References 4 publications

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“…Such diffuse 67 Ga uptake, of course, should be carefully differentiated from bacterial pneumonia, viral infection, pneumocystis carinii infection, and tumor extension. Although it is controversial whether radiation pneumonitis extends over the irradiated lung or not, a few cases with radiation pneumonitis extending outside the RT field radiographically or histopathologically have been reported (15)(16)(17)(18)(19)30). The present study supports the possibility that radiation pneumonitis sometimes extends beyond the irradiated lung.…”

Section: Discussionsupporting

confidence: 81%

Gallium-67 citrate imaging for the assessment of radiation pneumonitis

Kataoka

1989

Ann Nucl Med

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In order to evaluate its usefulness in the assessment of radiation pneumonitis, gallium-67 citrate (67Ga) imaging was performed before and after radiation therapy (RT) on 103 patients with lung cancer. In 23 patients with radiation pneumonitis detected radiographically, abnormal 67Ga uptake in sites other than tumors was found in all post-RT 67Ga lung images. Three patterns of uptake were found: (A), focal uptake corresponding to the RT field (n = 10); (B), diffuse uptake including the RT field (n = 4), and (C), diffuse uptake outside the RT field (n = 9). The area of 67Ga uptake was consistent with that of interstitial pneumonitis as revealed histopathologically in 7 cases. 67Ga uptake in pattern (C) was an indicator of poor prognosis for the patients with radiation pneumonitis. 67Ga uptake in the patients with reversible pneumonitis disappeared with steroid therapy. Sixteen (20%) of 80 asymptomatic patients, in whose chest radiographs there was no finding of radiation pneumonitis, showed transient 67Ga uptake. These were considered to occur in the subclinical radiation pneumonitis. These data suggest that 67Ga imaging is more sensitive than chest radiography in the detection of radiation pneumonitis and is useful in the assessment of the extent and clinical course of radiation pneumonitis.

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Section: Discussionsupporting

confidence: 81%

Gallium-67 citrate imaging for the assessment of radiation pneumonitis

Kataoka

1989

Ann Nucl Med

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“…This is associated with significant clinical symptoms and, in some patients respiratory failure will develop. 298 Most patients respond satisfactorily to corticosteroids.…”

Section: Adverse Effects Of Radiation Therapy To the Chestmentioning

confidence: 99%

Drug-Induced Respiratory Disease in Patients with Hematological Diseases

Camus¹,

Costabel²

2005

Seminars in Respiratory and Critical Care Medicine

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Patients with hematological malignancies or recipients of hematopoietic stem cell transplants may develop myriad pulmonary manifestations, as a complication of either the disease or the diverse agents used to treat the disease. Clinical, radiographic, and physiological features of drug-induced and radiation-induced pulmonary injury are often difficult to distinguish from other causes of pulmonary infiltrates (e.g., infections, pulmonary edema, alveolar hemorrhage, etc.). Fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) is essential to exclude infectious etiologies. In some cases, surgical lung biopsies are required to establish a specific etiological diagnosis. This review discusses the myriad causes of lung injury/toxicity that may afflict patients with hematological malignancies or transplant recipients, and presents diagnostic and therapeutic approaches.

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“…The acute phase occurs about 1 to 2 months after irradiation, the intermediate phase from 2 to 9 months, and the late phase after 9 months. 61,[64][65][66][67][68] During the acute or early stage, there are endothelial cell changes, swelling of the basement membranes, degenerative appearing changes of the type II pneumocytes, and inflammatory cell infiltration. In the late stages, there is a decrease in the number of capillaries, regeneration of new capillaries and reduced capillary permeability.…”

Section: Radiologymentioning

confidence: 99%

Chemotherapeutic Drug-Induced Pulmonary Disease

Rosenow¹

1980

Semin Respir Crit Care Med

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Hyperacute Radiation Pneumonitis

Cited by 18 publications

References 4 publications

Gallium-67 citrate imaging for the assessment of radiation pneumonitis

Gallium-67 citrate imaging for the assessment of radiation pneumonitis

Drug-Induced Respiratory Disease in Patients with Hematological Diseases

Chemotherapeutic Drug-Induced Pulmonary Disease

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