Hyperammonaemia and Spongy Degeneration of the Brain in Sheep Affected with Hepatic Necrosis

Hooper, Paula; Best, Susan M.; Murray, Denise R.

doi:10.1016/s0034-5288(18)33754-8

Cited by 21 publications

(1 citation statement)

References 31 publications

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“…Spongy change and development of Alzheimer type II cells have been typical for hepatocerebral disease in man, and in Wilsons disease due to abnormal Cu metabolism , and such changes in sheep may be an analogue (Fell 1981). In sheep injected with alkaloids, vacuolization of the brain stem showed a positive correlation with amounts of blood ammonia (Hooper et al 1974). Brain vacuolization has also been found in sheep with lupinosis (Allan & Nottle 1979),Cu poisoning (Doherty et al 1969), or ARGT (Berry et al 1980.…”

Section: Changes In Other Organsmentioning

confidence: 93%

Ovine White-Liver Disease (OWLD). Pathology

Ulvund¹

1990

Acta Vet Scand

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Ulvund M.J.: Ovine white-liver disease (OWLD) . Pathology. Acta vet. scand. 1990, 31, 309-324. -Microscopic liver changes could earliest be found after I month on OWLD pasture, and included extensive fatty change with large spherical vacuoles in hepatocytes, varying size of hepatocytes and nuclei, and formation of Councilman bodies. Later came ceroid deposits, biliary hyperplasia and mesenchymal proliferation . Changes occurred in all lambs which died or were killed due to OWLD, and altogether 83070 of the lambs grazing OWLD pastures showed typicalor suspect changes. Widespread haemosiderosis of the spleen was common. In severely affected lambs, sclerosis of the Peyer's patches and of the germinative centres of the intestinal lymph nodes were seen, as were neuronal atrophy and patchy microcavitation of areas in the brain stem. Four had polyvasculitis. Cobalt/vitamin B Il supplemented lambs showed no specific changes. Lambs which grew well on other pastures (H lambs), but which were subclinicallyCO/B I2 deficient some years, showed no fulminant hepatic OWLD, but 15% developed some features seen in OWLD. They showed no extensive fatty change. Results indicate that OWLD is a manifestation of B Il deficiency worsened by factors triggering early hepatic fatty change resulting in a more severe liver damage with loss of intracellular homeostasis rendering the hepatocytes vulnerable to other elements, like copper. sheep; cobalt/vitamin BI2 deficiency.

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Section: Changes In Other Organsmentioning

confidence: 93%

Ovine White-Liver Disease (OWLD). Pathology

Ulvund¹

1990

Acta Vet Scand

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Chronic copper poisoning and changes in the central nervous system of sheep

Howell

Blakemore²,

Gopinath

et al. 1974

Acta Neuropathol

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Spongy degeneration in the central nervous system of domestic animals

Hooper

1975

Acta Neuropathol

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Spongy degeneration or status spongiosus of the central nervous system (CNS) was described in a number of domestic animal species, notably sheep, cattle, pigs and in one goat. The condition was characterized by diffuse or focal vacuolation, or polymicrocavitation of the CNS, particularly the white matter. The vacuolation showed a well defined pattern of distribution following a number of myelinated tracts in CNS white matter, in isolated fibres crossing grey matter in the brain stem, and along grey and white matter borders in the cerebrum and spinal cord. The vacuoles were not altered by a variety of methods of rapid brain fixation, processing and staining. The appearance of the vacuolation repeatedly favouring the same areas in the CNS in a large number of animals studied, its common origin either by hepatocerebral disease or hyperammonaemia, strongly suggests that CNS spongy degeneration of domestic animals is a distinct disease entity.

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Hyperammonaemia and Spongy Degeneration of the Brain in Sheep Affected with Hepatic Necrosis

Cited by 21 publications

References 31 publications

Ovine White-Liver Disease (OWLD). Pathology

Ovine White-Liver Disease (OWLD). Pathology

Chronic copper poisoning and changes in the central nervous system of sheep

Spongy degeneration in the central nervous system of domestic animals

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