Hyperammonämische Enzephalopathie bei multiplem Myelom

“…There exists some data about the probability of occurrence of delirium in MM and acute leukemia involving the hyperammonemic encephalopathy which is characteristic for this disease [25][26][27][28][29][30] . In a systematic study of D. Vybornykh et al (2006) [31] .…”

Section: Somatogenic Psychosesmentioning

confidence: 99%

Psychohematology. Attempt to Summarise

Выборных

Olexenko

Savchenko

2016

International Journal of Hematology Research

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AIM:This article describes studies involving mental and personality disorders in patients with blood diseases -disorders typology, prevalence, risk factors for developing of mental disturbances and their treatment. METHODS:The work is done on the basis of scientific literature search in various databases and analysis of the resulting material. RESULTS: There was obtained information on the prevalence, typologies, risk factors and treatment of blood diseases in the available literature. CONCLUSIONS: The presented data of literature suggests clinical heterogeneity and a wide range (from asthenic reactions to delirious states) of psychopathological disorders detected in blood diseases patients. The main risk factors are severe underlying disease, chemotherapy management (especially corticosteroids), elderly patients. In most cases of adjustment disorders there was observed a combination of several risk factors (both general and specific). In the context of the tolerability and safety of pharmacotherapy preference was given to atypical antipsychotics and new generations of antidepressants (SSRI, SNRI). It remains to study the mental disorders and personality disorders, which are formed in patients with specific malignant and nonmalignant (hemophilia, thrombocytopathy etc.) diseases and to develop differentiated approaches to pharmacotherapy and psychotherapy in such states.

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“…Hyperammonemia (HAE) has been described in association with a variety of tumors, including typical and fibrolamellar HCC, neuroendocrine tumors, gastrointestinal stromal tumors (GIST), and myeloma [9][10][11][12]. We present a case report of a severe HAE in a patient treated for HCC and propose a diagnosis and treatment algorithm of HAE in fibrolamellar HCC.…”

Section: Introductionmentioning

confidence: 99%

Hyperammonemic Encephalopathy Associated With Fibrolamellar Hepatocellular Carcinoma: Case Report, Literature Review, and Proposed Treatment Algorithm

et al. 2016

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We report a case of a 31-year-old man with metastatic fibrolamellar hepatocellular carcinoma (FLHCC) treated with gemcitabine and oxaliplatin complicated by hyperammonemic encephalopathy biochemically consistent with acquired ornithine transcarbamylase deficiency. Awareness of FLHCC-associated hyperammonemic encephalopathy and a pathophysiology-based management approach can optimize patient outcome and prevent serious complications. A discussion of the management, literature review, and proposed treatment algorithm of this rare metabolic complication are presented. The Oncologist 2016; 21:514-520Implications for Practice: Pathophysiology-guided management of cancer-associated hyperammonemic encephalopathy can improve patient outcome and prevent life-threatening complications. Community and academic oncologists should be aware of this serious metabolic complication of cancer and be familiar with its management.

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Hyperammonämische Enzephalopathie bei multiplem Myelom

Abstract: The existence of respiratory alkalosis and multiple myeloma should prompt a search for hyperammonemia.

Cited by 5 publications

References 8 publications

Multiple Myeloma-Induced Hyperammonemic Encephalopathy

Multiple Myeloma-Induced Hyperammonemic Encephalopathy

Psychohematology. Attempt to Summarise

Hyperammonemic Encephalopathy Associated With Fibrolamellar Hepatocellular Carcinoma: Case Report, Literature Review, and Proposed Treatment Algorithm

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