2013
DOI: 10.1177/0004563213500658
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Hyperamylasaemia and dual paraneoplastic syndromes in small cell lung cancer

Abstract: We hereby describe the rare case of a 59-year-old patient presenting with marked hyperamylasaemia mimicking acute pancreatitis upon admission. Investigation of co-existent hypokalemia revealed the presence of ectopic adrenocorticotropic hormone secretion, leading to the final diagnosis of small cell lung cancer, exhibiting dual paraneoplastic syndromes including Cushing Syndrome and hyperamylasaemia. Although, paraneoplastic syndromes occur commonly, paraneoplastic hyperamylasaemia especially in the context of… Show more

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Cited by 9 publications
(6 citation statements)
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“…Therefore, we think that paraneoplastic symptoms might be the cause for this patient's syncope although we did not test the Hu, anti-Yo, or other antibodies. Paraneoplastic syndromes are rare disorders that are triggered by an altered immune system response to a neoplasm, which might be the first or most prominent manifestation of a cancer, specifically small cell carcinomas of the lung [ 13 ]. In a broad sense, these syndromes are collections of symptoms that result from substances produced by the tumor, and they occur remotely from the tumor itself.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, we think that paraneoplastic symptoms might be the cause for this patient's syncope although we did not test the Hu, anti-Yo, or other antibodies. Paraneoplastic syndromes are rare disorders that are triggered by an altered immune system response to a neoplasm, which might be the first or most prominent manifestation of a cancer, specifically small cell carcinomas of the lung [ 13 ]. In a broad sense, these syndromes are collections of symptoms that result from substances produced by the tumor, and they occur remotely from the tumor itself.…”
Section: Discussionmentioning
confidence: 99%
“…
We read with interest the case report by Akinosoglou et al 1 on hyperamylasaemia in association with lung cancer, and the accompanying editorial by Crook. 2 Both noted the rarity of hyperamylasaemia in association with malignancy.
…”
mentioning
confidence: 96%
“…Rather than being a result of tumour ectopic secretion, the hyperamylasaemia may be due to tissue hypoxia secondary to high catecholamine concentrations that elicit vasoconstriction and decreased organ perfusion. [19][20][21] In summary, there are many causes of hyperamylasaemia including as part of the paraneoplastic syndrome, as illustrated by Akinosoglou et al 1 …”
mentioning
confidence: 99%
“…Hyperamylasaemia: don't forget undiagnosed carcinoma MA Crook 1,2,3 The case report in this issue by Akinosoglou et al 1 describes increased serum amylase activity in a patient with a small oat cell tumour of the lung. Alpha amylase is a relatively small 45 kDa enzyme that breaks down glycogen and starch to maltose and dextrin.…”
mentioning
confidence: 99%
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