Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma

Sawamura, Takaya; Nakada, Hiroshi; Hazama, Hiroshi; Shiozaki, Yasuko; Sameshima, Yoshiko; Tashiro, Yutaka

doi:10.1016/0016-5085(84)90185-9

Cited by 154 publications

(53 citation statements)

References 24 publications

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“…Asialoglycoprotein is exclusively internalized into hepatocytes by a receptor (10), and therefore, a decrease in the number of asialoglycoprotein receptors is specifically observed in injured livers (21). Since 1996, our department has used 99m Tc-GSA scintigraphy preoperatively combined with ICGR15 and conventional liver function tests.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study

et al. 2006

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To clarify the relationship between morphological measurements of hepatic volume by computed tomography (CT-vol) and functional volume (RI-vol) by technetium-99m galactosyl human serum albumin (99mTc-GSA) scintigraphy, and its clinical significance, we examined 16 patients with a background liver status of either normal liver function (n=4), chronic hepatitis or cirrhosis (n=7), or obstructive jaundice (n=5). In five patients who underwent preoperative portal vein embolization (PVE), volumetric measurement was performed 2 weeks after PVE. The mean values of CT-vol and RI-vol of the right lobe were 692+/-147 cm3 (66.1+/-10.7%) and 668+/-159 cm3 (67.8+/-13.2%), respectively, and those of the left lobe were 329+/-138 cm3 (33.9+/-10.6%) and 328+/- 170 cm3 (32.2+/-13.2%), respectively. There were no significant differences in the volume measurements between the two volumetric techniques. Correlations between CT-vol and RI-vol in the right and left lobes were positive and significant (r=0.912 and 0.903, respectively; both P's<0.001). The mean values of post-PVE CT-vol and RI-vol of the right lobe in five patients were significantly different (628+/-149 and 456+/-211 cm3, respectively; P=0.033). However, the mean values of post-PVE CT-vol and RI-vol of the left lobe were not different (496+/-124 and 483+/-129 cm3, respectively). We propose that volumetric measurement by 99mTc-GSA scintigraphy is useful for detecting changes in functional volume of individual lobes of the liver and is a more dynamic method compared with detection of morphological changes by CT scan.

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Section: Discussionmentioning

confidence: 99%

Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study

et al. 2006

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“…Among these trials, tests using 99m Tc-GSA scintigraphy, such as LHL15 [11,12,21], heart activity at 15 min by heart activity at 3 min (HH15) [21], the modified receptor index determined by LHL15/HH15 [21], and the maximal removal rate (Rmax) [8], were shown to be very reliable and noninvasive without requiring blood sampling for evaluating hepatic functional reserve. Asialoglycoprotein is exclusively internalized into hepatocytes by a receptor [7] and, therefore, a decrease in the number of asialoglycoprotein receptors is specifically observed in the injured liver [28]. 99m Tc-GSA scintigraphy resolved the problems of ICGR15 and its use rapidly spread in Japan [8,9,[11][12][13]21].…”

Section: Discussionmentioning

confidence: 99%

Relationship between indocyanine green test and technetium-99m galactosyl serum albumin scintigraphy in patients scheduled for hepatectomy: Clinical evaluation and patient outcome

Nanashima¹

2004

Hepatology Research

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“…Sawamura et al reported that specific receptor activity was scarcely observed in HCC and varied in the surrounding cirrhotic liver (7). Nanashima et al reported that Tc-99m-GSA scintigraphy is useful for detecting changes in functional volume of the liver compared with detection of morphological changes by CT scan (8).…”

Section: Introductionmentioning

confidence: 98%

Feasibility and Efficacy of Single Photon Emission Computed Tomography-Based Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma 8 cm or More With Portal Vein Tumor Thrombus in Combination With Transcatheter Arterial Chemoembolization

Shirai¹,

Sato²,

Suwa³

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma

Cited by 154 publications

References 24 publications

Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study

Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study

Relationship between indocyanine green test and technetium-99m galactosyl serum albumin scintigraphy in patients scheduled for hepatectomy: Clinical evaluation and patient outcome

Feasibility and Efficacy of Single Photon Emission Computed Tomography-Based Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma 8 cm or More With Portal Vein Tumor Thrombus in Combination With Transcatheter Arterial Chemoembolization

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