Hyperbaric Oxygen in the Treatment of Actinomycosis

Manheim, Sylvan D.

doi:10.1001/jama.1969.03160290104028

Cited by 15 publications

(3 citation statements)

References 4 publications

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“…A few case reports suggest hyperbaric oxygen therapy may be used as an adjunct with antimicrobial and surgical treatment in refractory actinomycosis infections [13,14] .…”

Section: Discussionmentioning

confidence: 99%

Primary Actinomycosis of the Leg: A Case Report and Literature Review

Alabdalaaly

Albahli

Almutairi

2022

ijirms

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Actinomycosis is an indolent, slowly progressive, suppurative infection caused by gram-positive branching bacteria of the genus Actinomyces. The disease actinomycosis most commonly occurs in 3 body regions: cervicofacial (55% of patients), abdominopelvic (20%), and pulmonothoracic (15%). Primary infection of an extremity is an uncommon feature of actinomycosis. We present a case of rare primary Actinomycosis of the lower extremity.

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“…A few case reports suggest hyperbaric oxygen therapy may be used as an adjunct with antimicrobial and surgical treatment in refractory actinomycosis infections [13,14] .…”

Section: Discussionmentioning

confidence: 99%

Primary Actinomycosis of the Leg: A Case Report and Literature Review

Alabdalaaly

Albahli

Almutairi

2022

ijirms

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“…Very limited information is available on the use of HBO for treating actinomycosis. However, in cases of refractory actinomycosis, HBO can be added as an adjunctive therapy [ 18 ]. It works by stimulating the formation of hydrogen peroxide and free radicals, which are toxic to the anaerobic environment.…”

Section: Discussionmentioning

confidence: 99%

A case series of actinomycosis from a single tertiary care center in Saudi Arabia

Elzein

Kharraz

Arab

et al. 2019

IDCases

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Actinomycosis is an uncommon but curable chronic infection caused by Actinomyces spp. The cervicofacial region is the most susceptible to infection; however, other sites may also become infected. Data on the current prevalence of this rare disease in Riyadh, Saudi Arabia is lacking. We herein report a case series of four patients with actinomycosis from a single tertiary care center in Riyadh, Saudi Arabia.Three patients presented to us with slowly progressing actinomycosis and one patient developed an acute abdomen, secondary to viscus perforation. Two of the patients had cervicofacial disease, including hard palate actinomycosis. Tissue cultures were sent for three patients; however, tests for actinomycosis were negative. Subsequently, the diagnosis was made through histopathological examination. Therapy involved a combination of surgical resection and debridement and prolonged antimicrobial treatment tailored to each patient.The cases reported in this series highlight the difficulty in diagnosing actinomycosis. For most patients, the diagnosis was delayed or accidentally discovered on histopathological examination. We conclude that increased awareness among physicians is needed for early diagnosis and treatment of actinomycosis.

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“…Both clinical and laboratory data support the use of hyperbaric oxygen (HBO) for clostridial myonecrosis (6,7,10). Its use for other anaerobic infections is theoretically feasible, but almost no clinical or experimental data are available (11,16 ,ug/ml), hemin (5 itg/ml), and 6% rabbit serum.…”

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confidence: 99%

Hyperbaric Oxygen Exposures for Intrahepatic Abscesses Produced in Mice by Nonsporeforming Anaerobic Bacteria

Hill

1976

Antimicrob Agents Chemother

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Hyperbaric oxygen exposures were evaluated for treatment of progressive liver abscesses produced by intraperitoneal injection of combined cultures of Fusobacterium necrophorum plus either Bacteroides fragilis subsp. fragilis or Fusobacterium nucleatum in a mouse model. Infected control and hyperbaric oxygen-exposed mice were autopsied 5 or 6 weeks after inoculation of bacteria and were assigned numerical pathology scores according to the number and size of abscesses present. Seventeen daily 3-h exposures to 100% O 2 at 2 atmospheres absolute pressure begun either 1 day or 1 week after injection of bacteria significantly reduced the number and size of abscesses among mice infected with either mixture of anaerobic organisms. Abscesses due to mixed fusobacteria were often completely resolved. These data support the efficacy of hyperbaric oxygen for treatment of mixed anaerobic infection produced by Bacteroides and Fusobacterium species and suggest its further evaluation as a potential alternate or adjunct to present therapy for certain types of serious anaerobic infection.

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Hyperbaric Oxygen in the Treatment of Actinomycosis

Cited by 15 publications

References 4 publications

Primary Actinomycosis of the Leg: A Case Report and Literature Review

Primary Actinomycosis of the Leg: A Case Report and Literature Review

A case series of actinomycosis from a single tertiary care center in Saudi Arabia

Hyperbaric Oxygen Exposures for Intrahepatic Abscesses Produced in Mice by Nonsporeforming Anaerobic Bacteria

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