Hyperbaric oxygen therapy and osteonecrosis

Ceponis, Peter J. M.; Keilman, Clinton G.; Guerry, C; Freiberger, JJ

doi:10.1111/odi.12489

Cited by 39 publications

(20 citation statements)

References 175 publications

(222 reference statements)

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“…In the opposite direction, hyperoxia could have a beneficial effect on the bone. Treatment with high concentration of oxygen in the hyperbaric chamber has proven useful in osteomyelitis and osteonecrosis of the jaw caused by radiotherapy or by the use of bisphosphonates [7][8][9] . HC accelerates osteogenic differentiation of mesenchymal cells and decreases the activation of osteoclasts [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Influencia del oxígeno a alta concentración en cámara hiperbárica sobre el metabolismo óseo

Salmón-González

Anchuelo

Borregán

et al. 2020

Rev Osteoporos Metab Miner

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Objectives: To learn how high concentration in hyperbaric oxygen therapy (HBO) acts on the expression of genes related to bone metabolism in osteoblast cell lines and human trabecular bone. Material and methods: The differential expression of several genes related to bone metabolism (SOST, RUNX2, MMP14, OPG, HIF-1α and SIRT1) in two human osteoblastic cell lines (Saos and Super-Saos) and in human trabecular bone fragments subjected to one, three or five HBO sessions (90 minutes, 100% oxygen; 2.3 atmospheres). In each experiment, a control that did not receive HBO was used. Results: We did not find significant differences after HBO in the expression of the genes studied, neither in the cells nor in trabecular bone. Only in the Super-Saos cell line the expression of OPG after 5 sessions of HBO decreased 6 times with respect to that of the control group (2-ΔCt Ct of 72; p=0.01). Conclusions: High concentration oxygen in the hyperbaric chamber (HC) does not seem to influence the expression of genes related to bone metabolism.

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Section: Introductionmentioning

confidence: 99%

Influencia del oxígeno a alta concentración en cámara hiperbárica sobre el metabolismo óseo

Salmón-González

Anchuelo

Borregán

et al. 2020

Rev Osteoporos Metab Miner

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“…Dysgeusia, paresthesia, bone exposure, gingival ulceration, tooth fracture, pathologic mandibular fracture, xerostomia, and orocutaneous fistula are common within the oral cavity. All of the following induce extreme irritation and pain, and often lead to more severe complications if not treated in a timely manner 25. HBOT increases the oxygen tension in the region and promotes angiogenesis, the development of new blood cells.…”

Section: Uses In Dentistrymentioning

confidence: 99%

Clinical utility of hyperbaric oxygen therapy in dentistry

Patel

Gandhi

et al. 2019

Med Gas Res

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This fuller impact of the use of hyperbaric oxygen therapy within dentistry is taking greater notice with newer research findings. There are new advancements in research regarding postradiotherapy cases, osteonecrosis of the jaw, osteomyelitis, periodontal disease, and dental implants. Hyperbaric oxygen therapy can even be used in conjunction with other procedures such as bone grafting. Although the research and clinical utility has come a long way, there are several complications to be mindful of during the application of hyperbaric oxygen therapy.

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“…Different authors have confirmed that this therapy prevents bone loss in BRONJ, so it seems to be a good treatment when applied during the early stages [13,14]. Ozone has been showed to repair necrotic bone lesions.…”

Section: Discussionmentioning

confidence: 84%