Hyperbaric Oxygen Therapy as an Alternative Therapeutic Option for Radiation-Induced Necrosis Following Radiotherapy for Intracranial Pathologies

Hajikarimloo, Bardia; Kavousi, Shahin; Jahromi, Ghazaleh Ghaffaripour; Mehmandoost, Mahdi; Oraee-Yazdani, Saeed; Fahim, Farzan

doi:10.1016/j.wneu.2024.01.161

Cited by 3 publications

References 62 publications

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Phototactic/Photosynthetic/Magnetic‐Powered Chlamydomonas Reinhardtii‐Metal‐Organic Frameworks Micro/Nanomotors for Intelligent Thrombolytic Management and Ischemia Alleviation

Chiang,

Liu,

Rethi

et al. 2024

Adv Healthcare Materials

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Thrombosis presents a critical health threat globally, with high mortality and incidence rates. Clinical treatment faces challenges such as low thrombolytic agent bioavailability, thrombosis recurrence, ischemic hypoxia damage, and neural degeneration. This study developed biocompatible Chlamydomonas Reinhardtii micromotors (CHL) with photo/magnetic capabilities to address these needs. These CHL micromotors, equipped with phototaxis and photosynthesis abilities, offer promising solutions. A core aspect of this innovation involves incorporating polysaccharides (glycol chitosan (GCS) and fucoidan (F)) into ferric Metal‐organic frameworks (MOFs), loaded with urokinase (UK), and subsequently self‐assembled onto the multimodal CHL, forming a core‐shell microstructure (CHL@GCS/F‐UK‐MOF). Under light‐navigation, CHL@GCS/F‐UK‐MOF is shown to penetrate thrombi, enhancing thrombolytic biodistribution. Combining CHL@GCS/F‐UK‐MOF with the magnetic hyperthermia technique achieves stimuli‐responsive multiple‐release, accelerating thrombolysis and rapidly restoring blocked blood vessels. Moreover, this approach attenuates thrombi‐induced ischemic hypoxia disorder and tissue damage. The photosynthetic and magnetotherapeutic properties of CHL@GCS/F‐UK‐MOF, along with their protective effects, including reduced apoptosis, enhanced behavioral function, induced Heat Shock Protein (HSP), polarized M2 macrophages, and mitigated hypoxia, are confirmed through biochemical, microscopic, and behavioral assessments. This multifunctional biomimetic platform, integrating photo‐magnetic techniques, offers a comprehensive approach to cardiovascular management, advancing related technologies.

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Phototactic/Photosynthetic/Magnetic‐Powered Chlamydomonas Reinhardtii‐Metal‐Organic Frameworks Micro/Nanomotors for Intelligent Thrombolytic Management and Ischemia Alleviation

Chiang,

Liu,

Rethi

et al. 2024

Adv Healthcare Materials

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Hyperbaric Oxygen in Otorhinolaryngology: Current Concepts in Management and Therapy

Collettini,

Zoccali,

Barbato

et al. 2024

Oxygen

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Background: In otorhinolaryngology and head and neck surgery, oxygen is a therapeutic tool used for various pathologies. Oxidative stress is the imbalance between the production of free radicals (ROS) and the antioxidant capacity of the body, which can represent the pathogenesis of several pathologies or contribute to their worsening. This narrative review aims to analyze the benefits, indications, and side effects of hyperbaric oxygen therapy (HBOT) in different head and neck disorders. Methods: The search was carried out on multiple electronic databases such as PubMed and Google Scholar, and prospective, randomized, and reviewed studies were analyzed from January 1982 to February 2024. Results and Conclusions: The most common tools used to manage oxidative stress in the ear, nose, and throat (ENT) field are continuous positive airway pressure (CPAP) and HBOT. A common ENT pathology, while the latter can be used for osteoradionecrosis treatment in head and neck cancer patients, infections, malignant external otitis, head and neck reconstruction, facial cosmetic surgery, and among patients with sudden sensorineural hearing loss. From our analysis, it emerged that HBOT is a currently used effective therapy in various ENT pathologies’ treatment, alone or in association with other treatments; it can guarantee functional recovery and healing depending on the type of pathology for which it is used and on its severity.

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Wound Care in Cancer Patients

Kilic

2024

Oncological Rehabilitation a Handbook for Healthcare Professionals

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Cancer treatment can cause various skin and mucosa injuries. These injuries, which seriously reduce the quality of life of patients, should be well identified, evaluated, treated and necessary protective measures taken by healthcare professionals. Having a standardized wound assessment tool ensures consistent and accurate transfer of information among healthcare providers. To provide infection control, it is important to select appropriate antibiotic agents and appropriate antimicrobial dressins or solutions. They should be able to use evidence-based practices in wound care. In addition to all these physiological interventions, it should be able to offer interventions to solve the psychosocial problems that the wound may cause on the patient and his family.

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Hyperbaric Oxygen Therapy as an Alternative Therapeutic Option for Radiation-Induced Necrosis Following Radiotherapy for Intracranial Pathologies

Cited by 3 publications

References 62 publications

Phototactic/Photosynthetic/Magnetic‐Powered Chlamydomonas Reinhardtii‐Metal‐Organic Frameworks Micro/Nanomotors for Intelligent Thrombolytic Management and Ischemia Alleviation

Phototactic/Photosynthetic/Magnetic‐Powered Chlamydomonas Reinhardtii‐Metal‐Organic Frameworks Micro/Nanomotors for Intelligent Thrombolytic Management and Ischemia Alleviation

Hyperbaric Oxygen in Otorhinolaryngology: Current Concepts in Management and Therapy

Wound Care in Cancer Patients

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