Hyperbaric oxygen therapy for chronic wounds

Kranke, Peter; Bennett, Michael H; James, Marrissa Martynâ€St; Schnabel, Alexander; Debus, Sebastian; Weibel, Stephanie

doi:10.1002/14651858.cd004123.pub4

Cited by 311 publications

(169 citation statements)

References 77 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…Hyperbaric oxygen therapy (HBOT) has been demonstrated to accelerate wound healing through the resulting cellular effects of enhanced intravascular oxygen concentration and pressure . Although a positive effect on wound healing has been depicted in numerous trials, the pooled data of the Cochrane review reflected improved ulcer healing rates with HBOT in the short term but not in the long term . No studies have assessed the role of HBOT on the DHU alone .…”

Section: Methods Of Managementmentioning

confidence: 99%

Slow to heel: a literature review on the management of diabetic calcaneal ulceration

Khoo

Jansen

2018

International Wound Journal

View full text Add to dashboard Cite

The diabetic heel ulcer (DHU) represents a reconstructive challenge to clinicians and the multidisciplinary team alike. It is traditionally viewed as a condition that is inherently difficult to treat due to the intrinsic anatomical vulnerabilities of the heel. In addition to this, several factors are associated with poorer end outcomes - namely, that of major amputation. These include peripheral vascular disease, infection/osteomyelitis and the size of the ulcer itself. In light of the significant morbidity, economic burden and mortality seen in this cohort of patients, this review aims to explore current treatment modalities that have been undertaken. Literature in this field has mostly been confined to a handful of small case studies, some of which reflect novel, multimodal approaches, and promising results. Management with osteotomy, flap reconstruction and acellular dermal matrices, amongst other options, is covered within this review.

show abstract

Section: Methods Of Managementmentioning

confidence: 99%

Slow to heel: a literature review on the management of diabetic calcaneal ulceration

Khoo

Jansen

2018

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…Treatment of chronic wounds involves various approaches to protect and promote healing. These include hyperbaric oxygen therapy (HBOT) , vacuum‐assisted wound closure , low‐level laser therapy and electrical stimulation . However, results from these studies are inconsistent and reported limited success with no conclusive remark on its effect .…”

Section: Introductionmentioning

confidence: 99%

Extracorporeal shockwave therapy for the treatment of chronic wound of lower extremity: current perspective and systematic review

Omar

Gwada

Shaheen

et al. 2017

International Wound Journal

View full text Add to dashboard Cite

The purpose of this study was to provide an up-to-date review for the accurate estimation of the efficacy of extracorporeal shock wave therapy (ESWT) on the healing of chronic wounds on the lower extremity (CWLE). A systematic review of 10 databases for clinical trials about ESWT in the management of CWLE published between 2000 and 2016 was performed. A total of 11 studies with 925 patients were found. Expert therapists assessed the methodological qualities of the selected studies using the Physiotherapy Evidence Database (PEDro) scale and categorised each study according to Sackett's levels of evidence. Eight studies were categorised as level II; two studies were categorised as level III and one study was categorised as level V. In conclusion, this review demonstrated mild to moderate evidence to support the use of ESWT as an adjuvant therapy with a standardised wound care programme. However, it is difficult to draw firm conclusions about the efficacy of ESWT. So, future researches with high methodological quality are required to assess the efficacy and cost-effectiveness of this relatively new physical therapy application.

show abstract

“…Absolute contraindications include doxorubicin treatment (because of cardiac toxicity), mafenide acetate treatment (because of central vasoconstriction), and untreated pneumothorax [15]. According to authors of a Cochrane review of chronic wounds, HBO 2 improved healing in the short term but not with long-term follow-up [16]. In experimental studies, HBO 2 treatment led to proliferation of bovine aortic endothelial cells and human skin fibroblasts in vitro as well as accelerated wound epithelialization and neovascularization in mouse ears [17, 18].…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen therapy for a refractory skin ulcer after radical mastectomy and radiation therapy: a case report

et al. 2017

View full text Add to dashboard Cite

BackgroundRadiation therapy is performed as an adjuvant therapy when indicated following surgical resection of malignant tumors. However, radiation exposure induces acute or chronic dermatitis, depending on the radiation dose, interval, tissue volume, or irradiated area of the body. Radiation-induced skin ulcers and osteomyelitis of the underlying bone are intractable late-stage complications of radiation therapy, and often require reconstructive surgery to cover exposed tissue. Hyperbaric oxygen therapy has been suggested as a treatment for delayed radiation injury with soft tissue and bony necrosis.Case presentationA 74-year-old Japanese female underwent left radical mastectomy for breast cancer (T3N3M0, stage IIIB) in 1987. Radiation therapy was initiated 6 weeks after the surgery. She received telecobalt-60 in a total dose of 50 Gy with 25 fractions to the left supraclavicular, parasternal and left axillary regions, and electron treatment (9 MeV) in a total dose of 50 Gy in 25 fractions to the left chest wall. After irradiation, her skin became thinner and more fragile on the left chest wall, but no severe infections were observed. She noticed a small ulcer that repeatedly healed and recurred in 2000. She visited the hospital where she received radiation therapy and was treated for a skin ulcer on the left chest wall in December 2012. A fistula developed and then pus was discharged in January 2013. She was referred to the hyperbaric medical center in February 2013, and the fistula (1.5 × 3 cm) with pus discharge was observed. She was diagnosed with a late-onset radiation-induced skin ulcer that developed 25 years after radical mastectomy. HBO2 (2.5 atmospheres absolute with 100% oxygen for 60 minutes) was indicated for the refractory ulcer and osteomyelitis of the ribs. The patient was treated with HBO2 a total of 101 times over the course of 1 year and completely recovered.ConclusionsHyperbaric oxygen therapy can be performed safely for even more than 100 sessions in patients with radiation-induced skin ulcers and osteomyelitis. Hyperbaric oxygen therapy can be considered as an alternative, conservative treatment when surgical resection for late-onset, radiation-induced skin ulcers is not indicated because of fragile skin in the irradiated areas.

show abstract

Hyperbaric oxygen therapy for chronic wounds

Cited by 311 publications

References 77 publications

Slow to heel: a literature review on the management of diabetic calcaneal ulceration

Slow to heel: a literature review on the management of diabetic calcaneal ulceration

Extracorporeal shockwave therapy for the treatment of chronic wound of lower extremity: current perspective and systematic review

Hyperbaric oxygen therapy for a refractory skin ulcer after radical mastectomy and radiation therapy: a case report

Contact Info

Product

Resources

About