Hyperbaric oxygen therapy for chronic wounds

Hyperbaric Oxygen in the Management of Chronic Diabetic Foot Ulcers

“…The "counterpoint" view by Berendt [7] concluded that "it is time that the advocates of HBO for diabetic foot ulcers organized large RCTs with placebo control to provide definitive answers to the question." Whereas a Cochrane systematic review concluded that HBO may improve healing and reduce amputation risk, it also suggested that the results be interpreted with caution because of the small number of studies and patients as well as methodologic and reporting inadequacies [8].…”

Therapieoptionen der Zukunft bei chronischen Wunden

“…Dabei wird vom Patienten während eines Aufenthalts in einer Überdruckkammer reiner Sauerstoff inhaliert. Grundgedanke ist, dass die relative Sauerstoffarmut in der Wunde für deren schlechte Heilung verantwortlich ist [19]. Gerade diese Therapieform wird, begünstigt durch die unklare Studienlage, kontrovers diskutiert [20].…”

“…Diese bestehen aus der Möglichkeit von toxischen Einflüssen des Sauerstoffs auf ZNS und Lunge sowie Barotraumata für Ohren, Lungen und Sinus. In der Mehrheit der Anwendungen kommt es außerdem zu einer in der Regel temporären Myopie [19]. Nicht zuletzt der enorme finanzielle Aufwand spricht gegen diese Art der Therapie.…”

Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial

“…HBOT increases the oxygen content of plasma and body tissues (Gill and Bell 2004), and has been shown in animal models to reduce inflammation and improve measures of oxidative stress (Lin et al 2005;Yasar et al 2003). HBOT is an effective treatment for decompression sickness (Leach et al 1998) and is likely effective for the treatment of diabetic foot ulcers (Kranke et al 2004). Although it is sometimes used for the treatment of other medical conditions that involve acute or chronic hypoxia, there is currently insufficient evidence to determine if HBOT is effective for traumatic brain injury (McDonagh et al 2004), acute ischemic stroke (McDonagh et al 2003, idiopathic sudden sensorineural hearing loss (Bennett et al 2007), and other conditions.…”